Clinical trials: Metastases, CNS
Cervical Cancer, Chronic Myeloproliferative Disorders
Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter
RATIONALE: The use of dalteparin may be able to prevent complications caused by the use of a catheter to supply chemotherapy to cancer patients. It is not yet known if dalteparin is effective in reducing these complications.
- Conditions
- Cervical Cancer, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00006083
- Testing
- Fragmin
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Brain Metastases From Solid Tumors
SMART Trial: Cognitive Sparing Brain Radiotherapy for Multiple Brain Metastases
The goal of this phase II randomized trial is to determine if Stereotactic Radiosurgery (SRS) or Cognitive Sparing WBRT (CS-WBRT) better preserves neurocognitive function than standard Hippocampal Avoidance WBRT (HA-WBRT) in…
- Trial name
- NCT07505979
- Testing
- SRS, CS-WBRT, HA-WBRT
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Epilepsy, Partial Seizures
Efficacy and Safety of Levetiracetam in Partial Seizures Control, With or Without Secondary Generalization
The purpose of this study is to determine whether levetiracetam as adjunctive therapy is effective in the treatment of partial seizures, with or without secondary generalization, associated with refractory focal epilepsy.
- Trial name
- Mozart (NCT01392768)
- Testing
- Levetiracetam
- Volunteers
- 126 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Male Breast Cancer, Stage IV Breast Cancer
Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer
This phase I trial is studying the side effects and best dose of cediranib maleate when given together with whole brain radiation therapy in treating patients with brain metastases from non-small cell lung cancer.
- Conditions
- Male Breast Cancer, Stage IV Breast Cancer, Stage IV Melanoma, Stage IV Non-small Cell Lung Cancer
- Trial name
- NCT00937482
- Testing
- cediranib maleate, whole-brain radiation therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Safety Study of an Immunomodulating Microparticle to Treat Progressive Multiple Sclerosis
The purpose of the study is to determine the safety and tolerability, dose-limiting toxicities, maximum tolerated dose, and recommended therapeutic dose of intravenously administered MIS416 weekly in patients with chronic…
- Trial name
- NCT01191996
- Testing
- MIS416
- Where
- New Zealand
- Volunteers
- 34 people
- Sponsor
- Innate Immunotherapeutics
Post Stroke, Post-Traumatic Headache
Aerobic Exercise and Transcranial Low Laser Therapy in Patients With Central Nervous System Injury
Objective of this protocol will be to evaluate the parameters related to the function of the musculoskeletal and cardiorespiratory system, through a rehabilitation and training program for people with acquired central nervous…
- Conditions
- Post Stroke, Post-Traumatic Headache, Spinal Injuries, Cerebral Palsy, Spastic
- Trial name
- NCT03751306
- Testing
- Transcranial Photobiomodulation, Cardiorespiratory Rehabilitation
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Universidade do Vale do Paraíba
NSCLC (Non-small Cell Lung Carcinoma), Leptomeningeal Metastasis
Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI
A Prospective Study of Zorifertinib Combined with Intra-Ommaya Reservoir Cerebrospinal Fluid Chemotherapy for Leptomeningeal Progression in NSCLC Patients After Third-Generation EGFR-TKI Therapy
- Conditions
- NSCLC (Non-small Cell Lung Carcinoma), Leptomeningeal Metastasis, EGFR-TKI Sensitizing Mutation, Zorifertinib
- Trial name
- NCT07551414
- Testing
- Zorifertinib Plus Intra-Ommaya CSF Chemotherapy
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer, Brain Metastases
Whole Brain Radiotherapy (WBRT) With Sorafenib for Breast Cancer Brain Metastases (BCBM)
Sorafenib is a new type of anti-cancer drug. It belongs to a new class of medications known as tyrosine kinase inhibitors. Sorafenib is thought to work against cancer in many ways. It helps decrease blood supply to the tumor.
- Trial name
- NCT01724606
- Testing
- Whole Brain Radiotherapy (WBRT), Sorafenib
- Where
- 6 sites in United States
- Volunteers
- 21 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stroke, Transient Ischemic Attack
International PFO Consortium
The prevalence of patent foramen ovale (PFO) is about 25% in the general population and approximately 40% in patients who have ischemic stroke of unknown cause (cryptogenic stroke).
- Trial name
- NCT00859885
- Testing
- Antithrombotic treatment, percutaneous device closure of PFO
- Where
- 18 sites in United States, Belgium and 4 more
- Volunteers
- 1,500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Leptomeningeal Metastasis, Immune Checkpoint Inhibitor
Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer
immune checkpoint inhibitor combined with recombinant human endostatin can improve the 3-month OS rate of leptomeningeal metastasis of lung cancer, and the combination is safe
- Conditions
- Leptomeningeal Metastasis, Immune Checkpoint Inhibitor, Endostatin
- Trial name
- NCT05385185
- Testing
- Camrelizumab or envafolimab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Hebei Medical University
Lung Cancer With Central Nervous System Metastasis
Non-small Cell Lung Cancer With Central Nervous System Metastasis
Cerebrospinal fluid was obtained from the cerebrospinal cavity of non-small cell lung cancer patients with central nervous system metastasis, blood was obtained from veins, and metastatic lung cancer tumor tissue was obtained…
- Trial name
- NCT06026735
- Testing
- lung cancer with brain /leptomeningeal metastasis
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Cervicogenic Headache
Dose Related Effects of Radial Extracorporeal Shock Wave Therapy on Upper Trapezius Trigger Points in Patients With Cervicogenic Headache.
A randomized double blinded controlled trial will be conducted to determine and compare the effects of low and medium dose radial extracorporeal shock wave therapy on upper trapezius trigger points in patients with cervicogenic…
- Trial name
- NCT06879418
- Testing
- Low dose shock wave therapy plus strengthening and stretching exercise for upper trapezius, Medium dose shock wave therapy plus strengthening and stretching exercise for upper trapezius
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- MTI University
Metastatic Cancer
Radiation Therapy Following Surgery to Remove Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation therapy after surgery to remove brain metastases may decrease the amount of radiation required to treat brain metastases.
- Trial name
- NCT00003320
- Testing
- surgical procedure, radiation therapy, stereotactic radiosurgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Mild Traumatic Brain Injury, Headaches Posttraumatic
SMART Concussion Trial: Symptom Management vs Alternative Randomized Treatment of Concussion Trial
Given the rising rates of concussion in youth ages 10-19 and the significant proportion of young people who remain symptomatic for months following concussion, research evaluating the efficacy of multifaceted treatment options…
- Conditions
- Mild Traumatic Brain Injury, Headaches Posttraumatic, Neck Pain, Dizziness
- Trial name
- SMART (NCT05446597)
- Testing
- Symptom-specific Headache Treatment, Symptom-specific Dizziness &/or Neck Pain Treatment, Multimodal Concussion Treatment
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Calgary
Stroke, Apoplexy
Healthy Lifestyles After Stroke - Stroke Coach
The purpose of this study is to examine the efficacy of a lifestyle modification telehealth program on health-related behaviours in community-dwelling individuals living with stroke.
- Conditions
- Stroke, Apoplexy, Cerebral Stroke, Cerebrovascular Accident
- Trial name
- StrokeCoach (NCT02207023)
- Testing
- Healthy Lifestyle Training Program
- Where
- 7 sites in Canada
- Volunteers
- 126 people
- Sponsor
- University of British Columbia
Cervicogenic Headache
Mulligan SNAG Versus Active Release Technique in Cervicogenic Headache
This study is designed to compare two different manual therapy approaches for individuals with cervicogenic headaches, a type of headache that originates from the neck. Participants will be randomly assigned to one of two groups.
- Trial name
- NCT07132047
- Testing
- Mulligan Mobilization SNAG with Home Exercise, Active Release Technique with Home Exercise
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Primary Central Nervous System Lymphoma (PCNSL), Secondary Central Nervous System Lymphoma (SCNSL)
PD-1 Inhibitor Combined With Rituximab, Methotrexate, and Orelabrutinib (PD-1i+RMO) for Newly Diagnosed PCNSL and SCNSL.
This is a multicenter, open-label, single-arm, prospective clinical study of PD-1 inhibitor combined with rituximab, methotrexate, and orelabrutinib (PD-1i+RMO) in the treatment of newly diagnosed primary central nervous system…
- Trial name
- NCT07410520
- Testing
- PD -1/PD-L1 monoclonal antibody, Rituximab (R), Methotrexate
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sleep Apnea, Spinal Cord Injuries
Untreated Sleep Apnea as an Aggravating Factor for Other Secondary Medical Conditions After Spinal Cord Injury
This cross-sectional prospective study will assess the potential association of more severe sleep apnea after spinal cord injury with more intense neuropathic pain, more severe spasticity, and more significant cardiovascular…
- Conditions
- Sleep Apnea, Spinal Cord Injuries, Spasticity, Muscle, Neuropathic Pain
- Trial name
- NCT05687097
- Testing
- Home-based sleep screening test or hospital-unattended sleep screening test, Cardiovascular beat-to-beat monitoring, ECG monitoring
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Breast Cancer, Leukemia
Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00237627
- Testing
- PS-341, Doxil, Velcade
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Headache Disorders, Secondary, Headache Disorders
NUMITOR Study: Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting
The NUMITOR study is an analytical observational study with an multicenter ambisective (retrospective and prospective) cohort design.
- Conditions
- Headache Disorders, Secondary, Headache Disorders, Central Nervous System Diseases, Brain Diseases
- Trial name
- NUMITOR (NCT05475769)
- Testing
- Clinical evaluation
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
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