Clinical trials: Metastases, CNS
Cervicogenic Headache
CORRELATION BETWEEN FORWARD HEAD POSTURE, CERVICAL MUSCLES ENDURANCE, AND PROPRIOCEPTIVE FUCTIONS IN CERVICOGENIC HEADACHE AMONG LATE ADOLESCENT STUDENTS.
Forward Head Posture (FHP) is a common postural deviation characterized by anterior translation of the head relative to the trunk, which increases load on cervical muscles and joints.
- Trial name
- NCT07763886
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Delta University for Science and Technology
MRI-guided Adaptive Radiotherapy, Non-small Cell Lung Cancer
Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Brain Metastasis
This study aims to explore the safety and efficacy of eliminating the planning target volume (PTV) margins based on MRI-guided adaptive stereotactic radiotherapy for non-small cell lung cancer (NSCLC) patients with brain…
- Conditions
- MRI-guided Adaptive Radiotherapy, Non-small Cell Lung Cancer, Brain Metastasis
- Trial name
- NCT06582940
- Testing
- MRI-guided adaptive SRT, Conventional SRT
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Sun Yat-sen University
Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis
Safety and Efficacy of S103 Cells in Progressive/Refractory Multiple Sclerosis
This study is a single-center, open-label, single-arm, exploratory clinical study to evaluate the safety, tolerability, and preliminary efficacy of S103（BCMA-CAR T ）cells in the treatment of progressive or refractory multiple…
- Conditions
- Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis, Multiple Sclerosis (MS) Secondary Progressive, Refractory Multiple Sclerosis
- Trial name
- RESET-MS (NCT07587125)
- Testing
- S103 cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Xijing Hospital
Breast Cancer, Metastatic Cancer
Irinotecan and Temozolomide in Treating Patients With Breast Cancer Who Have Received Previous Treatment for Brain Metastases
RATIONALE: Drugs used in chemotherapy, such as irinotecan and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00617539
- Testing
- irinotecan hydrochloride, temozolomide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Carcinoma, Receptor, ErbB-2
Evaluation of 68-GaNOTA-Anti-HER2 VHH1 Uptake in Brain Metastasis of Cancer Patients
This study investigates the uptake of the radiopharmaceutical 68-GaNOTA-Anti-HER2 VHH1 in brain metastasis using PET/CT imaging.
- Trial name
- NCT03331601
- Testing
- 68GaNOTA-Anti-HER2 VHH1
- Where
- Belgium
- Volunteers
- 7 people
- Sponsor
- Universitair Ziekenhuis Brussel
Headache, Migraine
Psychological Assessment and Treatment of Chronic Benign Headache
Subjects with chronic migraine or tension headaches will receive 12 sessions of biofeedback or relaxation training after fulfilling screening, intake interviews, \& psychological testing requirements.
- Conditions
- Headache, Migraine, Tension Headache, Stress Headache
- Trial name
- NCT00018811
- Testing
- Relaxation training & thermal biofeedback, Surface EMG biofeedback
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Non-Small Cell Lung Cancer, Brain Metastases
Icotinib Combined With Radiation Therapy For NSCLC Patients With Brain Metastases and EGFR Mutation
The purpose of this study is to evaluate the efficacy of icotinib in combination with radiotherapy for NSCLC patients with brain metastases. The primary endpoint is PFS of intracranial lesions
- Trial name
- NCT03754530
- Testing
- Icotinib, WBRT or SRS
- Volunteers
- 162 people
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Postdural Puncture Headache, Lumbar Puncture
Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache
Post-dural puncture headache (PDPH) is the most prevalent complication in patients undergoing diagnostic or therapeutic lumbar puncture (LP).
- Trial name
- NCT06640634
- Testing
- active in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), active in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS)
- Where
- Italy
- Volunteers
- 97 people
- Sponsor
- Neuromed IRCCS
Breast Neoplasm, Brain Neoplasm
Temozolomide as a Prophylaxis Against Brain Recurrence in Participants With Metastatic Breast Cancer (P05225 AM2)
The purpose of this study is to determine whether temozolomide can be used as a prophylaxis against brain recurrence in participants with metastatic breast cancer.
- Conditions
- Breast Neoplasm, Brain Neoplasm, Second Neoplasm
- Trial name
- STOP (NCT00638963)
- Testing
- temozolomide
- Volunteers
- 6 people
- Sponsor
- Merck Sharp & Dohme LLC
Post-Traumatic Headache
Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache
The aim is to investigate whether opening of ATP-sensitive potassium (KATP) channels induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury…
- Trial name
- NCT05243953
- Testing
- Levcromakalim
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Postdural Puncture Headache
Study Evaluating Sphenopalatine Ganglion Block (SPGB) for Treatment of Postdural Puncture Headache (PDPH)
Postdural puncture headaches (PDPH) are a consequence of spinal and epidural anesthesia in approximately 1% of cases when performed in obstetric patients.
- Trial name
- PDPH (NCT02365909)
- Testing
- 0.5% bupivacaine, normal saline
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Multiple Sclerosis
Evaluating the Use of Oral Indapamide to Reduce Disabiltiy Progression in Progressive Multiple Sclerosis (MS)
The goal of this clinical trial is to determine whether treatment with indapamide can slow the rate of progression in patients with progressive forms of multiple sclerosis (MS).
- Trial name
- INDAMS (NCT07765212)
- Testing
- Indapamide
- Volunteers
- 75 people
- Sponsor
- Eva M.M. Strijbis
Leptomeningeal Metastases
Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease
This pilot clinical trial studies continuous intraventricular methotrexate in treating patients with leptomeningeal disease. Drugs used in chemotherapy, such as methotrexate, work in different ways to stop the growth of cancer…
- Trial name
- NCT01438021
- Testing
- pharmacological study, methotrexate
- Sponsor
- City of Hope Medical Center
Breast Cancer
Tesetaxel Plus Reduced Dose of Capecitabine vs. Capecitabine in HER2 Negative, HR Positive, LA/MBC
CONTESSA is a multinational, multicenter, randomized, Phase 3 study of tesetaxel in patients with HER2 negative, HR positive LA/MBC previously treated with a taxane in the neoadjuvant or adjuvant setting.
- Trial name
- CONTESSA (NCT03326674)
- Testing
- Tesetaxel and Capecitabine, Capecitabine
- Where
- 207 sites in United States, Australia and 17 more
- Volunteers
- 685 people
- Sponsor
- Odonate Therapeutics, Inc.
Brain Metastases, Adult
Accelerated Checkpoint Therapy for Any Steroid Dependent Patient With Brain Metastases
Immunotherapy treatments are intended to boost a person's immune system to fight their cancer. Treatment with immunotherapy has been shown to be effective in a wide range of cancers, including melanoma skin cancer, lung cancer…
- Trial name
- ACT-FAST (NCT04461418)
- Testing
- Glucocorticoid therapy
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- AHS Cancer Control Alberta
Multiple Sclerosis (MS), Multiple Sclerosis (MS) Relapsing Remitting
Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography
This study aims to: analyze prospectively the prevalence of subclinical oculomotor disorders (OMDs) in different phenotypes of Multiple Sclerosis (MS) and to study correlations with brain MRI T2 data.
- Conditions
- Multiple Sclerosis (MS), Multiple Sclerosis (MS) Relapsing Remitting, Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis (MS) Secondary Progressive
- Trial name
- EYE-SEP (NCT04705610)
- Testing
- Video-oculography / Social cognition tasks / Neuropsychological evaluations
- Where
- Monaco
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Association de Recherche Bibliographique pour les Neurosciences
Lower Extremity Dysfunction, Stroke
Sensitivity to Change of the Lower Extremity Functional Scale in Patients With Stroke
The purpose of this study was to investigate the reliability, construct validity, and sensitivity to change of the Lower Extremity Functional Scale (LEFS) in individuals affected by stroke.
- Trial name
- NCT01536990
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Non-small Cell Lung Cancer Metastatic
A Study to Evaluate Effectiveness and Safety of Tyrosine Kinase Inhibitors
This is a real-world non-interventional observational study. The study was designed to evaluate the effectiveness and safety of clinical treatments in the patients with advanced non-small cell lung cancer (NSCLC) complicated with…
- Trial name
- NCT03424980
- Testing
- Tyrosine kinase inhibitors
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Metastases of Central Nervous System, Melanoma
Study to Evaluate the Efficacy and Safety of Temozolomide in Subjects With Brain Metastases of Either Malignant Melanoma, Breast, or Non-small Cell Lung Cancer (P02064)
The study implies a 2 step study design. Patients are enrolled into 3 separate groups for melanoma, breast, and non-small cell lung cancer. In the first step, 21 patients per disease group are enrolled.
- Conditions
- Metastases of Central Nervous System, Melanoma, Breast Neoplasm, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT00831545
- Testing
- Temozolomide
- Volunteers
- 162 people
- Sponsor
- Merck Sharp & Dohme LLC
Metastatic Malignant Neoplasm to the Adult Brain
Robotic Compared to Fixed Gantry Radiosurgery for Brain Metastases
Radiosurgery is precisely delivered high dose radiation. It can be performed using multiple cobalt sources, a modified traditional gantry-based linear accelerator or a robotic linear accelerator.
- Trial name
- TRICK (NCT01353573)
- Testing
- Fixed Gantry Radiosurgery, Robotic Radiosurgery
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Hamilton Health Sciences Corporation
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