Clinical trials: Metastases, CNS
Metastatic Breast Cancer, Advanced Non-Small Cell Squamous Lung Cancer
HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease
The goal of this phase II clinical trial] is to analyze the efficacy of patritumab deruxtecan (HER3-DXd) in patients with metastatic breast cancer (MBC) or advanced non-small cell lung cancer (aNSCLC) with active brain metastases…
- Conditions
- Metastatic Breast Cancer, Advanced Non-Small Cell Squamous Lung Cancer, Solid Tumor, Adult
- Trial name
- TUXEDO-3 (NCT05865990)
- Testing
- Patritumab deruxtecan
- Where
- 8 sites in Austria, Spain
- Volunteers
- 63 people
- Sponsor
- MedSIR
Medication Overuse Headache
Is Detoxification Needed in Medication-overuse Headache?
Medication-overuse headache (MOH) is a disabling condition, yet treatable. According to European guidelines and based on evidence, multidisciplinary detoxification is the first choice of treatment for MOH.
- Trial name
- DEFINE3 (NCT02993289)
- Testing
- Different well-known treatments
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
NSCLC Stage IV, Brain Metastases
Tislelizumab Combined With Pemetrexed/ Carboplatin in Patients With Brain Metastases of Non-squamous NSCLC
This is a phase II, Open-Label, Multicenter, Prospective Clinical Study to Investigate the Efficacy and Safety of Tislelizumab Combined with Pemetrexed/ Carboplatin in Patients with Brain Metastases of Non-squamous Non-small Cell…
- Conditions
- NSCLC Stage IV, Brain Metastases, PD-1 Antibody
- Trial name
- NCT04507217
- Testing
- Tislelizumab, Carboplatin, Pemetrexed
- Where
- 2 sites in China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-sen University
Brain Metastases
Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases
This is a single-arm, single-center pilot study in which 10 patients with one to four brain metastases diagnosed on brain magnetic resonance imaging (MRI) within the past 30 days will be evaluated for study eligibility and…
- Trial name
- NCT04545814
- Testing
- Stereotactic Radiosurgery, Surgical Resection, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical College of Wisconsin
Ischemic Stroke
Japan Statin Treatment Against Recurrent Stroke (J-STARS)
Although hyperlipidemia is not always the risk factor of stroke, inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase can decrease the incidence of stroke in the patient with ischemic heart disease.
- Trial name
- NCT00221104
- Testing
- Pravastatin
- Where
- Japan
- Volunteers
- 1,578 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis
Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis
Noninvasive brain stimulations (NIBS) will be used in MS patients with cognitive impairments to enhance their cognitive aptitudes.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis, Cognitive Deficits, Motor Deficits
- Trial name
- MScog-tDCS (NCT02266121)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive
Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis
The purpose of this study is to develop a measurement of walking quality, called Gait Deviation Index (GDI) for people with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis Relapse, Multiple Sclerosis, Relapsing-Remitting
- Trial name
- MS-GDI (NCT06516458)
- Testing
- Camera Based Kinematic Analysis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Gliomas, Brain Metastases, Adult
AI-assisted Diagnosis of Malignant Brain Tumors
This study aims to establish a large-scale, multi-center MRI database for malignant brain tumors. It will develop an artificial intelligence system for the segmentation and classification of multiple subtypes of brain tumors…
- Conditions
- Gliomas, Brain Metastases, Adult, Lymphoma, Brain Tumor Adult
- Trial name
- NCT07198256
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metastatic Malignant Neoplasm in the Adult Brain, Primary Brain Tumor
Neuropharmacokinetics of Eribulin Mesylate in Treating Patients With Primary or Metastatic Brain Tumors
This pilot trial studies the brain concentration of eribulin mesylate in treating patients with primary or metastatic brain tumors.
- Trial name
- NCT02338037
- Testing
- Therapeutic Conventional Surgery, Biopsy, Eribulin Mesylate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- City of Hope Medical Center
Brain Metastases
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have…
- Trial name
- NCT04246879
- Testing
- MRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Brain Tumor
MRI-Guided LITT for Treatment Metastatic Brain Tumors
The Methodist Hospital Neurological Institute is conducting a clinical trial for patients suffering from Metastatic brain tumors.
- Trial name
- NCT01736722
- Testing
- Visualase®
- Where
- United States
- Sponsor
- The Methodist Hospital Research Institute
NSCLC, Renal Cell Carcinoma
Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy
This study is designed to see if we can lower the chance of side effects from radiation in patients with breast, kidney, small cell lung cancer, non-small cell lung cancer or melanoma that has spread to the brain and who are also…
- Conditions
- NSCLC, Renal Cell Carcinoma, Breast Carcinoma, Melanoma
- Trial name
- HYPOGRYPHE (NCT05703269)
- Testing
- single fraction stereotactic radiosurgery (SSRS), fractionated stereotactic radiosurgery (FSRS)
- Where
- 34 sites in United States
- Volunteers
- 58 people
- Sponsor
- Wake Forest University Health Sciences
Postdural Puncture Headache
Aminophylline Prophylaxis For Postdural Puncture Headache
postdural puncture headache is a rare but serious complication of spinal anesthesia. many drugs were studied in prevention or treatment of that complication.
- Trial name
- NCT02150304
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Post-Dural Puncture Headache
Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture Headache
Objectives: To compare the safety and efficacy of IV aminophylline versus IV neostigmine/atropine mixture in the treatment of post-dural puncture headache (PDPH).
- Trial name
- RCT (NCT03997006)
- Testing
- IV Aminophylline, IV Neostigmine Methylsulfate + Atropine Sulphate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Brain Metastases
University of Kentucky Markey Cancer Center Neuro-Oncology Multi-Disciplinary Tumor Board Protocol for the Treatment of Advanced Brain Metastases
This study evaluates whether review by the University of Kentucky Markey Cancer Center Neuro-Oncology Multidisciplinary Tumor Board improves clinical outcomes for adults with advanced brain metastases.
- Trial name
- NCT07786311
- Testing
- Neuro-Oncology Multi-Disciplinary Tumor Board Review
- Volunteers
- 125 people
- Sponsor
- John L. Villano, MD, PhD
Stroke
Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)
This is a study in patients who recently had a brain attack (stroke) and in whom no clear cause of the stroke could be identified.
- Trial name
- NAVIGATE ESUS (NCT02313909)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Acetylsalicylic acid (Aspirin, BAY1019036)
- Where
- 454 sites in United States, Argentina and 29 more
- Volunteers
- 7,213 people
- Sponsor
- Bayer
Brain Metastases, Adult
A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases
The purpose of this study is to determine if the study drug, patritumab deruxtecan (HER3-DXd), can be measured in brain tumor tissue after recieving one dose of patritumab deruxtecan before surgery.
- Trial name
- PARAMETer (NCT05620914)
- Testing
- Patritumab deruxtecan
- Where
- United States
- Sponsor
- Mustafa Khasraw, MBChB, MD, FRCP, FRACP
REM Sleep Behavior Disorder, Pre-motor Parkinson Disease
Cardiac Changes in Early Parkinson's Disease: A Follow up Study
The purpose of this study is to investigate the long-term effects of treatment with the adrenergic blocker carvedilol on serial DaTscan, a dopamine transporter (DAT) single photon emission computerized tomography (SPECT) imaging…
- Conditions
- REM Sleep Behavior Disorder, Pre-motor Parkinson Disease, Symptomatic Parkinson Disease
- Trial name
- NCT04218968
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cedars-Sinai Medical Center
Non-hodgkin Lymphoma, B Cell
LIBERTY: Liquid Biopsy to Diagnose and Monitor CNS Involvement in High-risk B Cell Non-Hodgkin Lymphoma
Prevention and treatment of CNS relapse remains a great unmet clinical need in the management of aggressive B-NHL. Hence, investigating novel diagnostic tests is of paramount importance to improve risk-stratification of lymphoma…
- Trial name
- SAKK 38/23 (NCT06090162)
- Testing
- ctDNA detection
- Where
- 14 sites in Switzerland
- Volunteers
- 64 people
- Sponsor
- Swiss Cancer Institute
Multiple Sclerosis
Medication Usage and Patient Reported Outcomes Evaluation Via myBETAapp in Patients With Multiple Sclerosis Treated With Betaferon: a Pilot Study
The planned study will be a prospective, non-interventional, observational cohort study using the structure of a registry. Medication usage behavior will be observed for 6 months, while documentation behavior on the wellness…
- Trial name
- PROmyBETAapp (NCT03134573)
- Testing
- Interferon beta-1b (Betaferon, BAY86-5046), Betaconnect auto-injector, myBETAapp
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Bayer
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