Clinical trials: Metastases, CNS
Migraine Disorders, Medication Overuse Headache
Greater Occipital Nerve Block for Migraine With Medication Overuse Headache
Migraine is among the leading causes of disability worldwide. Inappropriate use of acute medications in the setting of primary headache, particularly migraine can result in a debilitating condition known as medication overuse…
- Conditions
- Migraine Disorders, Medication Overuse Headache, Greater Occipital Nerve Block
- Trial name
- GONB_MOH (NCT07568496)
- Testing
- Lidocaine 2% and Methylprednisolone 80 mg
- Where
- 3 sites in Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Cervicogenic Headache
CORRELATION BETWEEN FORWARD HEAD POSTURE, CERVICAL MUSCLES ENDURANCE, AND PROPRIOCEPTIVE FUCTIONS IN CERVICOGENIC HEADACHE AMONG LATE ADOLESCENT STUDENTS.
Forward Head Posture (FHP) is a common postural deviation characterized by anterior translation of the head relative to the trunk, which increases load on cervical muscles and joints.
- Trial name
- NCT07763886
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Delta University for Science and Technology
Multiple Sclerosis
Managed Access Program (MAP) for Patients Diagnosed With Secondary Progressive Multiple Sclerosis With Active Disease
The purpose of this MAP Cohort Treatment Plan is to allow access to siponimod for eligible patients diagnosed with Secondary Progressive Multiple Sclerosis with active disease.
- Trial name
- NCT04540861
- Testing
- Siponimod
- Sponsor
- Novartis Pharmaceuticals
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Collecting and Storing Blood Samples From Patients With Cancer
RATIONALE: Collecting and storing samples of blood from patients with cancer to test in the laboratory may help the study of cancer in the future.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00900120
- Sponsor
- University of Medicine and Dentistry of New Jersey
Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration
This clinical trial aims to demonstrate that metformin can prevent clinical disability in patients with progressive MS by stopping or slowing down neurodegeneration by enhancing endogenous remyelination.
- Conditions
- Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary-progressive Multiple Sclerosis
- Trial name
- NCT05893225
- Testing
- Metformin Hydrochloride 850 mg Oral Tablet
- Where
- 5 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Antwerp
Stroke
Effectiveness of Self-monitoring and Treatment of Blood Pressure Following Stroke or Transient Ischaemic Attack
This blinded end point RCT will recruit high risk TIA and mild stroke patients (through the emergency TIA clinics and the acute stroke services at the Norfolk \& Norwich University Hospital) who require anti-hypertensive therapy…
- Trial name
- TEST-BP (NCT02947490)
- Testing
- Self BP measurement, Standard Care, Standard BP management
- Where
- United Kingdom
- Volunteers
- 165 people
- Sponsor
- University of East Anglia
Non Squamous Non-small Cell Lung Cancer, Brain Metastases
Pemetrexed/Platinum With or Without Bevacizumab in Brain Metastases From Patients With EGFR/ALK Negative Non-Squamous Non-small Cell Lung Cancer
This is a multi-center phase 3 randomized controlled study to assess the efficacy of Pemetrexed/platinum with or without Bevacizumab on patients with brain metastasis from non-small cell lung cancer(NSCLC) harboring EGFR/ALK wild…
- Conditions
- Non Squamous Non-small Cell Lung Cancer, Brain Metastases, Bevacizumab
- Trial name
- NCT01951482
- Testing
- Pemetrexed/Platinum, Bevacizumab and Pemetrexed/platinum
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-sen University
Lymphoma, Large B-Cell, Diffuse
Tumor Heterogeneity in Diffuse Large B-cell Lymphoma in Relation to CNS Involvement and Cell-free DNA
The aim of the project is to clarify whether DLBCL exhibits mutational diversity among different lymph node tumors in one and the same patient.
- Trial name
- NCT04763148
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Herlev Hospital
Stroke
Cell-free DNA in Acute Stroke
Cell-free DNA (cfDNA) is an important pro-inflammatory and prothrombotic mediator. With this study the investigators aim to gain new insights into the role of cfDNA in stroke and to perform a combined analysis of cfDNA in the…
- Trial name
- CANTO (NCT06928675)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Central Nervous System Lymphoma
Loncastuximab Tesirine and Rituximab Following Stereotactic Radiosurgery in Patients With Central Nervous System Lymphomas (SOLAR)
The purpose of this clinical trial is to learn if drugs loncastuximab tesirine and rituximab (lonca-R) after stereotactic radiosurgery are safe and effective for treatment of central nervous system lymphomas.
- Trial name
- SOLAR (NCT06607549)
- Testing
- Loncastuximab tesirine and rituximab (Lonca-R)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
NSCLC
Toripalimab Combined With Anlotinib and SBRT in Patients With Untreated Brain Metastases of Driven Gene-negative NSCLC
The purpose of this study is to explore the efficacy and safety of toripalimab combined with anlotinib and SBRT for non-driver gene mutation untreated brain metastases non-small Cell Lung Cancer.
- Trial name
- NCT05021328
- Testing
- Toripalimab, Anlotinib, SBRT 7Gy✖️5 QD
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Hubei Cancer Hospital
Non-Small Cell Lung Cancer, Brain Metastases
Efficacy of Erlotinib for Brain Metastasis of Non-Small Cell Lung Cancer
This is a non-randomized open-label uncontrolled phase II trial evaluating efficacy and toxicity of erlotinib in patients with asymptomatic brain metastasis advanced NSCLC who was benefitted by first line chemotherapy.
- Trial name
- NCT00663689
- Testing
- erlotinib
- Volunteers
- 45 people
- Sponsor
- Guangdong Provincial People's Hospital
Multiple Sclerosis
Immunotherapy With BHT-3009 Alone or Combined With Atorvastatin in Patients With Multiple Sclerosis
This research study is being done to evaluate the safety of BHT-3009 alone and when combined with atorvastatin (Lipitor) in patients with multiple sclerosis (MS).
- Trial name
- NCT00103974
- Testing
- BHT-3009-01
- Where
- 4 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Bayhill Therapeutics
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
Dose-Escalation Study of T Cell Vaccine in Multiple Sclerosis
The purpose of the study is 1) to study the safety and tolerability of escalating doses of myelin peptide reactive T cells in MS patients and 2) to study the clinical effectiveness of T Cell Vaccine ion the clinical course of MS.
- Trial name
- DES (NCT00587691)
- Testing
- Tovaxin Autologous T Cell Vaccine
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Opexa Therapeutics, Inc.
Multiple Sclerosis, Primary Progressive Multiple Sclerosis
C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Progressive Multiple Sclerosis Refractory to Standard Therapy
This is a global, multicenter, Phase 1b/2 study evaluating the safety and efficacy of C-CAR168, an autologous anti-CD20/BCMA chimeric antigen receptor T-cell therapy, in participants with progressive multiple sclerosis refractory…
- Conditions
- Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary Progress Multiple Sclerosis (SPMS), Primary Progressive Multiple Sclerosis (PPMS)
- Trial name
- NCT07825389
- Testing
- C-CAR168
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- AbelZeta Inc.
Ischemic Stroke, Oral Anticoagulation
Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants
The Advancing knowledge in ischemic Stroke PatiEnts on oRal Anticoagulants (ASPERA) study aims to investigate characteristics of ischemic stroke cases occurring in patients on oral anticoagulation for atrial fibrillation (AF) or…
- Conditions
- Ischemic Stroke, Oral Anticoagulation, Atrial Fibrillation (AF), Outcome Assessment
- Trial name
- ASPERA (NCT06823466)
- Where
- 47 sites in Croatia, Denmark and 13 more
- Volunteers
- 200 people
- Sponsor
- University of L'Aquila
Brain Metastases
Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases
The aim of this study is to evaluate the clinical efficacy and safety of continuous Endostar infusion combined with radiotherapy for treatment of brain metastases.
- Trial name
- NCT01410370
- Testing
- 6MV-X ray, Endostar
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Brain and Central Nervous System Tumors, Lymphoma
Pemetrexed Disodium in Treating Patients With Recurrent Malignant Gliomas, Primary CNS Lymphoma, or Brain Metastases
RATIONALE: Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well pemetrexed disodium works in treating patients with…
- Conditions
- Brain and Central Nervous System Tumors, Lymphoma, Metastatic Cancer
- Trial name
- NCT00276783
- Testing
- pemetrexed
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Northwestern University
Medication Overuse Headache
Intravenous Treatments Used in Medication Overuse Headache Bridge Treatment
Medication overuse headache is the chronicity of headaches, which occurs more than 15 days a month, as a result of frequent use of painkillers, opioids or migraine attack drugs (ergotamine, triptan) in individuals with…
- Trial name
- NCT05608642
- Testing
- Intravenous hydration, Intravenous prednisolone, Intravenous lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Diskapi Teaching and Research Hospital
Metastasis to Brain of Unknown Primary
18F ML-10 for Early Detection of Response of Brain Metastases to SRS
The purpose of this study is to evaluate the potential of [18F]-ML-10 to serve as a non-invasive imaging tool for the early detection of apoptosis in brain metastases in response to radiation therapy, in patients subjected to…
- Trial name
- NCT00696943
- Testing
- ([18F]-ML-10)
- Volunteers
- 1 people
- Sponsor
- Aposense Ltd.
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