Clinical trials: Metastasis Colorectal Cancer
Colorectal Cancer, Liver Metastasis
Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis
This study is a multicenter ,randomization, open control study to evaluate the efficacy and safety of Raltitrexed-based chemotherapy and 5-fluorouracil-based chemotherapy in the peri-operative treatment of patients with Liver…
- Trial name
- NCT02453490
- Testing
- Raltitrexed-based chemotherapy, 5-fluorouracil-based chemotherapy
- Where
- 9 sites in China
- Volunteers
- 360 people
- Sponsor
- Zhejiang University
Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive
DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers
This phase II trial studies how well deoxyribonucleic acid (DNA) plasmid-encoding interleukin-12/human papillomavirus (HPV) DNA plasmids therapeutic vaccine INO-3112 and durvalumab work in treating patients with human…
- Conditions
- Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive, Metastatic Malignant Neoplasm, Recurrent Anal Canal Carcinoma
- Trial name
- NCT03439085
- Testing
- DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457, Durvalumab
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR)
The DRAGON 2 Trial
In the randomized controlled DRAGON 2 trial study subjects will be randomized between two arms, PVE alone (control group) and PVE/HVE (interventional group).
- Trial name
- DRAGON 2 (NCT05428735)
- Testing
- Embolization
- Where
- 24 sites in United States, Australia and 7 more
- Volunteers
- 348 people
- Sponsor
- Maastricht University
Lung Non-Small Cell Carcinoma, Mediastinal Neoplasm
Phase II Trial of Lung Chemoemobolization
This phase II trial evaluates how well transarterial chemoembolization (TACE) works for treating patients with non-small cell lung cancer or lung metastases.
- Conditions
- Lung Non-Small Cell Carcinoma, Mediastinal Neoplasm, Pleural Neoplasm, Lung Metastases From Any Primary
- Trial name
- NCT05672108
- Testing
- Computed Tomography, Ethiodized Oil, Mitomycin
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- City of Hope Medical Center
Colorectal Adenocarcinoma, Metastatic Cholangiocarcinoma
CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors
This phase I pilot trial studies the side effects of cluster of differentiation 8 (CD8)+ T cells in treating patients with gastrointestinal tumors that have spread to other places in the body.
- Conditions
- Colorectal Adenocarcinoma, Metastatic Cholangiocarcinoma, Metastatic Colorectal Carcinoma, Metastatic Digestive System Carcinoma
- Trial name
- NCT02757391
- Testing
- Adoptive Immunotherapy, Aldesleukin, Cyclophosphamide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Colorectal Cancer
An Observational Pilot Study Evaluating the Feasibility of Conducting Genome-Wide Association Studies Utilizing Subject Provided Information in Subjects With Locally Recurrent or MBC, MCRC, MNSCLC, RGBM or MRCC Treated With Avastin (Bevacizumab) (InVite)
This pilot, non-interventional, observational, Web-based, prospective cohort study is designed to collect self-reported safety and effectiveness and genetic data from subjects with locally recurrent breast cancer (BC) or…
- Conditions
- Breast Cancer, Colorectal Cancer, Non-Small Cell Lung Cancer, Glioblastoma
- Trial name
- NCT01598597
- Where
- 50 sites in United States
- Volunteers
- 276 people
- Sponsor
- Genentech, Inc.
Metastatic Colorectal Cancer (mCRC), Colorectal Neoplasms
Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes
This study will evaluate efficacy and safety of hydroxychloroquine combined with methotrexate, capecitabine and bevacizumab versus regorafenib in participants with refractory metastatic colorectal cancer with mutations in KRAS or…
- Trial name
- x-МАР (NCT06949982)
- Testing
- experimental group x-MAP, Regorafenib (BAY 73-4506)
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Sergey Orlov, MD
Refractory Metastatic Colorectal Cancer
Ivarmacitinib Combined With Camrelizumab and Fruquintinib for Patients With Metastatic Colorectal Cancer After Failure of Second-line or Later Treatment
For patients with metastatic colorectal cancer (mCRC) who have failed two or more lines of standard therapy, treatment options are extremely limited, and the prognosis remains poor, with objective response rates (ORRs) generally…
- Trial name
- NCT07896096
- Testing
- Ivarmacitinib Sulfate Tablets, Camrelizumab, Fruquintinib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Renmin Hospital of Wuhan University
Metastatic Colorectal Cancer
Study of Trastuzumab-emtansine in Patients With HER2-positive Metastatic Colorectal Cancer Progressing After Trastuzumab and Lapatinib.
This is a phase II, open label, multicenter study. Patients with advanced colon rectal cancer (CRC) harboring an amplified HER2 that have been previously treated and progressed with an aNti-HER2 treatment, will be treated with…
- Trial name
- RESCUE (NCT03418558)
- Testing
- Trastuzumab emtansine
- Where
- 3 sites in Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Colorectal Cancer Metastatic
Study to Evaluate Real-world Pharmacoeconomics of Panitumumab in Metastatic Colorectal Cancer Patients
This is a phase IV multicenter trial to evaluate real-world health outcomes and economic impact of panitumumab versus standard-of-care (SOC) in the treatment of patients with chemotherapy-refractory metastatic colorectal cancer…
- Trial name
- NCT02139215
- Where
- 5 sites in Canada
- Volunteers
- 72 people
- Sponsor
- PeriPharm
Metastatic Colorectal Adenocarcinoma
Trifluridine/Tipiracil Plus Bevacizumab Versus Trifluridine/Tipiracil Monotherapy in Refractory Metastatic Colorectal Cancer
This study is a retrospective study to compare the efficacy and safety between trifluridine/tipiracil (TAS-102) plus bevacizumab (BEV) with TAS-102 monotherapy in refractory metastatic colorectal cancer (mCRC) from November 2020…
- Trial name
- NCT05869097
- Testing
- Trifluridine/Tipiracil, Bevacizumab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Hunan Cancer Hospital
Metastatic Colorectal Cancer
FLOX + Cetuximab (Erbitux®) for Patients With Metastatic Colorectal Cancer and Wild Type K-RAS Tumor
The Nordic FLOX-regime consists of a combination of bolus 5-FU, leukovorin and oxaliplatin (Eloxatin®). Cetuximab (Erbitux®) is an antibody against the epidermal growth factor receptor (EGFR).
- Trial name
- NCT00660582
- Testing
- Cetuximab (Erbitux), Oxaliplatin (Eloxatin) + Fluorouracil + folinic acid
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 152 people
- Sponsor
- Per Pfeiffer
Metastatic Colorectal Cancer (CRC), Liposomal Irinotecan
A Clinical Study of Liposomal Irinotecan for Second-Line Therapy in Metastatic Colorectal Cancer
Phase II - Treatment Regimen Exploration Stage: 1. Evaluate the safety and efficacy of the following three treatment regimens: Liposomal irinotecan + 5-FU/LV + bevacizumab + Enlonstobart (Group A) Liposomal irinotecan + 5-FU/LV +…
- Conditions
- Metastatic Colorectal Cancer (CRC), Liposomal Irinotecan, Second-Line
- Trial name
- NCT07585279
- Testing
- Liposomal irinotecan + 5-FU/LV + bevacizumab + Enlonstobart, Irinotecan liposome + 5-FU/LV + Bevacizumab, Irinotecan + 5-FU/LV + Bevacizumab
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Hebei Medical University Fourth Hospital
Benign Neoplasm of Intestinal Tract, Primary Malignant Neoplasm of Intestinal Tract
Impact of Perioperative Intravenous Fluid Utilization on Postoperative Outcomes
Subjects undergoing surgery on the small or large bowel will be randomized to one of 2 groups, a normal fluid amount group and a reduced fluid amount group to evaluate the impact of this change on recovery after surgery.
- Conditions
- Benign Neoplasm of Intestinal Tract, Primary Malignant Neoplasm of Intestinal Tract, Secondary Malignant Neoplasm of Intestinal Tract
- Trial name
- NCT01563991
- Testing
- Normal fluid volume, Reduced fluid volume
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- The Cleveland Clinic
Liver Metastases
AvidinOX + [177Lu]DOTA-biotin (or 177Lu-ST2210) Complex in Patients With Liver Metastases From Colorectal Cancer
The purpose of the study is to assess a new treatment for patients with liver tumor metastases from colorectal cancer. The treatment has never been used in humans before.
- Trial name
- NCT02053324
- Testing
- AvidinOX/ST2210
- Where
- 4 sites in Austria, Italy
- Volunteers
- 14 people
- Sponsor
- Alfasigma S.p.A.
Gastric Cancer, Colo-rectal Cancer
Tislelizumab Plus Anlotinib for Immunotherapy Resistant Gastrointestinal Cancer
Immunotherapy acquired resistance was observed in clinical practice. The investigators intended to add anlotinib to PD-1 inhibitors, hoping reverse the resistance.
- Trial name
- NCT04777162
- Testing
- Tislelizumab, Anlotinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University
Colorectal Cancer Liver Metastases
Multimodal Model for Efficacy Prediction Cetuximab in Colorectal Cancer Liver Metastasis Patient
Establishment and validation of the deep learning model of Cetuximab efficacy in simultaneous RAS wild unresectable CRLM patients
- Trial name
- NCT05873972
- Testing
- Cetuximab
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00274872
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- 17 sites in France
- Volunteers
- 600 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Colon Cancer Liver Metastases, Liver Neoplasms
Associating Liver Partition With Portal Vein Ligation for Staged Hepatectomy (ALPPS) vs. Two-Stage Hepatectomy (TSH) for Marginally Resectable Colorectal Liver Metastases (CRLM)
Surgical resection has offered the best option for prolonged survival in patients with colorectal liver metastases. Limiting factor for major liver resections is the size of the future liver remnant (FLR).
- Conditions
- Colon Cancer Liver Metastases, Liver Neoplasms, Liver Diseases, Secondary Malignant Neoplasm of Liver
- Trial name
- ALPPSforCRLM (NCT02758977)
- Testing
- ALPPS, TWO STAGE HEPATECTOMY
- Where
- Switzerland
- Volunteers
- 214 people
- Sponsor
- University of Zurich
Metastatic Colorectal Cancer
Bevacizumab + Triplet Treatment for Untreated With Chemotherapy Metastatic Colorectal Cancer
The purpose of this study is to evaluate the efficacy and safety of fluorouracil (5-FU), levofolinate calcium (l-LV), oxaliplatin (L-OHP) and irinotecan hydrochloride hydrate (CPT-11) (FOLFOXIRI) plus bevacizumab in untreated…
- Trial name
- BeTRI (NCT02497157)
- Testing
- Oxaliplatin (L-OHP), Irinotecan hydrochloride hydrate (CPT-11), Continuous intravenous infusion of fluorouracil (CIV 5-FU)
- Where
- 7 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
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