Clinical trials: Metastasis Colorectal Cancer
Colorectal Cancer
Assessment of Clinically Related Outcomes and Biomarker Analysis for Translational Integration in Colorectal Cancer
A prospective, observational study on clinical outcomes of surgical management of primary and metastatic colorectal cancer Prospective collection of tissues to explore potential biomarkers in blood and/or primary or secondary…
- Trial name
- ACROBATICC (NCT01762813)
- Testing
- open and laparoscopic surgery
- Where
- Norway
- Volunteers
- 1,200 people
- Sponsor
- Helse Stavanger HF
Colorectal Cancer
Oxaliplatin in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Clinical trial to study the effectiveness of oxaliplatin in treating patients who have locally…
- Trial name
- NCT00040820
- Testing
- oxaliplatin
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Metastatic Colorectal Cancer
First-line FOLFOXIRI Plus Bevacizumab in BRAF Mutant Metastatic Colorectal Cancer
The purpose of this study is to prospectively verify if FOLFOXIRI plus bevacizumab as first-line treatment could be considered a promising approach to improve the outcome of BRAF mutant metastatic colorectal cancer patients
- Trial name
- NCT01437618
- Testing
- FOLFOXIRI plus bevacizumab
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Colorectal Liver Metastases
The Effect of Fish Oils on Human Hepatic Colorectal Metastases
The purpose of this study is to determine whether fish oils - a known source of omega-3 given intravenously (via a 'drip') will help cure secondary deposits in the liver from bowel cancer.
- Trial name
- NCT00942292
- Testing
- Lipidem- fish oil emulsion BBraun UK, Digital Contrast MRI scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospitals, Leicester
Colorectal Cancer Liver Metastasis
PULSAR Combined With PD-1 Ab and Chemotherapy Plus Bev. for CRLM
To explore Progression-Free-Survival(FPS) of PULSAR(personalized ultrafractionated stereotactic adaptive radiotherapy) combined with PD-1 Ab and Chemotherapy plus Bevacizumabfor CRLM
- Trial name
- NCT06788171
- Testing
- Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy, Bevacizumab, Capecitabine
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Fujian Cancer Hospital
Metastatic Breast Cancer, Colorectal Cancer
Educational Intervention to Adherence of Patients Treated by Capecitabine +/- Lapatinib
The purpose of this study is to evaluate the efficacy of the implementation of an educational program on adherence to capecitabine alone or in combination to lapatinib.
- Trial name
- ProMETheX (NCT01847599)
- Testing
- Educational Intervention to enhance the adherence of Patient treated by capecitabine +/- Lapatinib
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Jean Perrin
Advanced Colorectal Cancer
Effect of Curcumin on Dose Limiting Toxicity and Pharmacokinetics of Irinotecan in Patients With Solid Tumors
Curcumin is an extract of the tumeric root that has been shown to have anti-tumor properties in laboratory studies. Curcumin, and its parent spice, turmeric (curcuma longa), are the 4th most commonly purchased dietary supplement…
- Trial name
- NCT01859858
- Testing
- curcumin, Irinotecan
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Solid Tumor, Non-Small-Cell Lung Cancer
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
Genes contain genetic code which tell the body which proteins to make. Many types of cancer are caused by changes, or mutations, in a gene called KRAS.
- Conditions
- Solid Tumor, Non-Small-Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer
- Trial name
- NCT07094204
- Testing
- ASP5834, panitumumab
- Where
- 22 sites in United States, France and 3 more
- Volunteers
- 404 people
- Sponsor
- Astellas Pharma Inc
Colorectal Cancer Liver Metastases, Regorafenib
Regorafenib Combined With Irinotecan Drug-Eluting Beads for Colorectal Cancer Liver Metastases
This study is a multicentre, prospective, randomised trial, aims to evaluate the efficacy and safety of Irinotecan Drug-Eluting Beads combined with regorafenib as the third-line treatment for a patient with colorectal cancer…
- Trial name
- RIDER (NCT05794971)
- Testing
- Regorafenib and DIBIRI, Regorafenib
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Sun Yat-sen University
Metastatic Colon Cancer
REVERT - taRgeted thErapy for adVanced colorEctal canceR paTients
This is a clinical prospective, no-Profit, Interventional, Premarket Medical Device "early phase", multicentre, single-arm study, based on collecting data on predictive biomarkers of mCRC patients, integrate them with the results…
- Trial name
- REVERT (NCT05396807)
- Testing
- AI
- Where
- 6 sites in Italy, Romania and 1 more
- Volunteers
- 106 people
- Sponsor
- University of Rome Tor Vergata
Colorectal Neoplasms
Intra-arterial Hepatic Bevacizumab and Systemic Chemotherapy
The purpose of the study is to assessed the efficiency of treatment based on the objective response rate (RECIST 1.1)
- Trial name
- BEVIAC (NCT01677884)
- Testing
- Bevacizumab, Capecitabine, Irinotecan
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Metastatic Colorectal Cancer
A Study to Evaluate U3-1402 in Subjects With Advanced or Metastatic Colorectal Cancer
This study is designed to primarily evaluate the safety and efficacy of U3-1402 in participants with advanced or metastatic colorectal cancer (CRC) who have received at least 2 prior lines of therapy and will explore clinical…
- Trial name
- NCT04479436
- Testing
- Patritumab Deruxtecan
- Where
- 46 sites in United States, Belgium and 6 more
- Volunteers
- 40 people
- Sponsor
- Daiichi Sankyo
Colorectal Cancer
Study of Biomarkers in Tissue Samples From Patients With Metastatic Colon Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01012804
- Testing
- western blotting, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Sponsor
- Georgetown University
Advanced or Metastatic Solid Tumors
A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations
To evaluate the efficacy of naporafenib administered with trametinib in patients with rat sarcoma viral oncogene (RAS) Q61X solid tumors To evaluate the safety and tolerability of naporafenib administered with trametinib in…
- Trial name
- SEACRAFT-1 (NCT05907304)
- Testing
- Naporafenib, Trametinib
- Where
- 29 sites in United States, Australia and 3 more
- Volunteers
- 86 people
- Sponsor
- Erasca, Inc.
Metastatic Colorectal Cancer
Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer
The primary aim of phase II CEIL study is to evaluate the efficacy of cetuximab and envafolimab plus mFOLFOXIRI versus cetuximab plus mFOLFOX6 as first line treatment of patients with initially unresectable and previously…
- Trial name
- CEIL (NCT05959356)
- Testing
- Cetuximab + Envafolimab + mFOLFOXIRI, Cetuximab + mFOLFOX6
- Where
- 3 sites in China
- Volunteers
- 198 people
- Sponsor
- Sun Yat-sen University
Liver Metastases, Gastric Adenocarcinoma
CT Radiomics and Deep Learning-Based Non-Invasive Model for Tracing Primary Sites of Adenocarcinoma Liver Metastases: Automatic Differentiation of Multiple Primary Digestive Tumors
This is a retrospective observational study. Liver metastasis occurs frequently in digestive-system cancers. Identification of the primary tumor source of liver metastasis may pose clinical challenges.
- Conditions
- Liver Metastases, Gastric Adenocarcinoma, Colorectal Adenocarcinoma, Biliary Tract Adenocarcinoma
- Trial name
- NCT07871019
- Testing
- Retrospective image analysis
- Where
- China
- Volunteers
- 700 people
- Sponsor
- West China Hospital
Metastatic Colorectal Cancer
Induction Chemoterapy With Folfoxiri Plus Cetuxumab in Unresectable Colorectal Cancer Patient
This is a phase II randomized study of 4-months induction first-line chemotherapy with FOLFOXIRI + cetuximab followed by maintenance with cetuximab or bevacizumab in patients affected by KRAS wild type (wt) mCRC.
- Trial name
- MACBETH (NCT02295930)
- Testing
- folfoxiri+cetuximab+surgery+cetuximab, folfoxiri+cetuximab+surgery+bevacizumab
- Where
- 22 sites in Italy
- Volunteers
- 143 people
- Sponsor
- Gruppo Oncologico del Nord-Ovest
Metastatic Colorectal Cancer
Electroporation and Immunotherapy in Metastatic Colorectal Cancer
The trial is designed as an investigator initiated prospective phase 2 study in patients with metastatic pMMR colorectal cancer (CRC) to determine the safety and efficacy of calcium electroporation (CaEP) performed concurrently…
- Trial name
- ELI (NCT05609656)
- Testing
- Irreversible electroporation, Calcium electroporation, Pembrolizumab
- Where
- Denmark
- Volunteers
- 4 people
- Sponsor
- Ismail Gögenur
Solid Tumours, Sarcoma
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
The purpose of this study is to investigate the study drug, OKN4395, administered alone and in combination with pembrolizumab. The overall objectives of this study are to determine the safety and tolerability (degree to which…
- Conditions
- Solid Tumours, Sarcoma, HNSCC, Non Small Cell Lung Cancer
- Trial name
- INVOKE (NCT06789172)
- Testing
- OKN4395, Pembrolizumab, Fasting
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 146 people
- Sponsor
- Epkin
Colon Cancer, Rectal Cancer
Radiomics Assess of Bevacizumab Plus Chemo in Colorectal Cancer Liver Metastases
Colorectal carcinoma with liver metastasis is one of the major problems bothering physicians worldwide. Bevacizumab combined with chemotherapy is the standard treatment recommended by several guidelines.
- Conditions
- Colon Cancer, Rectal Cancer, Liver Metastases
- Trial name
- ROBOT (NCT04213222)
- Testing
- Bevacizumab
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University People's Hospital
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