Clinical trials: Metastasis to Liver
Liver Cancer, Metastatic Cancer
Chemotherapy in Treating Patients With Unresectable Primary or Metastatic Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of pyrazoloacridine in treating patients who have…
- Trial name
- NCT00003714
- Testing
- Pyrazoloacridine
- Sponsor
- M.D. Anderson Cancer Center
HIV, Hepatitis C
Injecting Drug Use Community Intervention Trial
The purpose of this study is to reduce the HIV/HCV incidence among the clients attending community-based methadone maintenance treatment (MMT) , and to prevent the secondary sexual transmission from HIV+ clients to their spouse…
- Conditions
- HIV, Hepatitis C, Syphilis, HSV-2
- Trial name
- NCT01108614
- Testing
- Intervention
- Where
- 5 sites in China
- Volunteers
- 12,000 people
- Sponsor
- National Center for AIDS/STD Control and Prevention, China CDC
Gastrointestinal Hemorrhage, Portal Hypertension
Secondary Prophylaxis After Variceal Bleeding in Non-Responders
Controlled and randomized study comparing combined treatment (nadolol and endoscopic ligation) versus nadolol associated with isosorbide mononitrate or prazosin according to hemodynamic response, in the prevention of esofagic…
- Conditions
- Gastrointestinal Hemorrhage, Portal Hypertension, Cirrhosis
- Trial name
- KT-2000 (NCT00450164)
- Testing
- esofagic varices ligation, Nadolol, Isosorbide mononitrate
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Colon Cancer Liver Metastasis
Prebiotic Effect of Eicosapentaenoic Acid Treatment for Colorectal Cancer Liver Metastases
A significant proportion of patients who undergo liver surgery to remove bowel cancer that has spread to the liver (metastases) develop disease recurrence and die from the disease.
- Trial name
- NCT04682665
- Testing
- Icosapent Ethyl Oral Capsule
- Where
- 2 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- University of Leeds
Pancreatic Cancer Metastatic to Liver, Oligometastasis
Microwave Ablation Combined With Chemotherapy in the Treatment of Pancreatic Cancer Oligohepatic Metastasis
This study is a prospective, single center, single arm, phase II clinical study in patients with liver metastasis after radical resection of pancreatic cancer.
- Trial name
- NCT04677192
- Testing
- Microwave Ablation combination with chemotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fudan University
Colorectal Neoplasms, Neuroendocrine Tumors
Yttrium-90 Radioembolization Using Glass Microspheres (TheraSphere) for Patients With Liver Metastases
This is a prospective pilot study designed to document safety and efficacy of liver-directed therapy for colorectal, neuroendocrine, cholangiocarcinoma, melanoma, and breast cancer metastases to the liver using Yttrium-90 glass…
- Conditions
- Colorectal Neoplasms, Neuroendocrine Tumors, Cholangiocarcinoma, Melanoma
- Trial name
- NCT01290536
- Testing
- Selective internal radiation therapy to the liver using Yttrium-90 glass microspheres (TheraSphere)
- Volunteers
- 42 people
- Sponsor
- Nicholas Fidelman, MD
Liver Cancer, Liver Metastases
Real-time Imaging of Holmium Radioembolization: a Feasibility Study
This is a feasibility study in which patients with liver tumors are treated with holmium radioembolization under real time MR imaging.
- Trial name
- Emeritus (NCT04269499)
- Testing
- QuiremSpheres®
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Local Control Rate, Side Effect
Proton Beam Therapy for Unresectable Liver Metastasis
The investigators performed the present study to evaluate the role of proton beam therapy for liver metastasis which is unresectable and unsuitable for radiofrequency ablation (RFA) in terms of local control and safety.
- Trial name
- NCT04456621
- Testing
- PBT
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer Liver Metastases, Regorafenib
Regorafenib Combined With Irinotecan Drug-Eluting Beads for Colorectal Cancer Liver Metastases
This study is a multicentre, prospective, randomised trial, aims to evaluate the efficacy and safety of Irinotecan Drug-Eluting Beads combined with regorafenib as the third-line treatment for a patient with colorectal cancer…
- Trial name
- RIDER (NCT05794971)
- Testing
- Regorafenib and DIBIRI, Regorafenib
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Sun Yat-sen University
Colorectal Liver Metastasis
Comparison of the Resection Site Order in Simultaneous Approach of Colorectal Liver Metastasis
Colorectal cancer frequently presents with liver metastases, and complete removal of both primary and liver tumors can significantly improve survival.
- Trial name
- CORSICO (NCT07272928)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Colorectal Cancer
Phase I Efficacy On Vascular Permeability In Patients With Advanced Colorectal Cancer
A Phase I, Open-Label Study To Assess The Effect of ZD6474 (ZACTIMA) On Vascular Permeability In Patients with Advanced Colorectal Cancer and Liver Metastases.
- Trial name
- NCT00496509
- Testing
- ZD6474 (Zactima) 100mg, Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MR), Biomarker Draws
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Genzyme, a Sanofi Company
Metastatic Melanoma, Pulmonary Metastases
Radiation Therapy With Combination Immunotherapy for Relapsed/Refractory Metastatic Melanoma
This is a Phase 1b/2 study designed to evaluate combination of the human T-cell cytokine Interleukin-2 (IL-2) and a checkpoint inhibitor Ipilimumab immediately following a course of hypofractionated palliative radiation therapy…
- Conditions
- Metastatic Melanoma, Pulmonary Metastases, Hepatic Metastases, Brain Metastases
- Trial name
- NCT03297463
- Testing
- Interleukin-2 & Ipilimumab (P-Ib), Interleukin-2 & Ipilimumab (P-II)
- Where
- United States
- Sponsor
- Masonic Cancer Center, University of Minnesota
Breast Cancer, Liver Metastases
BreCLIM-2 - A RCT Investigating Local Treatment for Breast Cancer Liver Metastases
Breast cancer is the second most common cancer in Sweden with an incidence of 8000 per year. The role of surgery for distant breast cancer metastasis beyond local lymph nodes remains controversial even though some reports suggest…
- Trial name
- BreCLIM-2 (NCT04079049)
- Testing
- Surgical intervention, Control
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Liver Metastases, Stereotactic Body Radiation Therapy
OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases
The purpose of this trial is to identify a safe maximum tolerated dose level for MRI-guided Stereotactic Body Radiation Therapy (SBRT) treatment of bowel and liver metastases, respectively.
- Conditions
- Liver Metastases, Stereotactic Body Radiation Therapy, MRI-guided Treatment
- Trial name
- NCT04020276
- Testing
- SBRT
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Uveal Melanoma, Liver Metastases
Isolated Hepatic Perfusion in Combination With Ipilimumab and Nivolumab in Patients With Uveal Melanoma Metastases
Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the primary tumour, metastatic disease will develop in approximately 35%-50% of the patients within 10 years.
- Trial name
- SCANDIUM II (NCT04463368)
- Testing
- Isolated hepatic perfusion, Ipilimumab, Nivolumab
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Vastra Gotaland Region
Advanced Solid Tumor With Lung and/or Liver Involvement
ML-016 in Advanced Cancer With Lung and/or Liver Involvement
This is an open-label, multi-center, phase 1/2 dose-escalation and dose expansion study evaluating the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of ML-016 in participants with advanced solid tumors with…
- Trial name
- NCT07723482
- Testing
- ML-016
- Where
- 3 sites in Australia
- Volunteers
- 108 people
- Sponsor
- BrYet US, Inc.
Colorectal Cancer
The Efficacy of Bevacizumab Combined With m-FOLFOXIRI in Borderline Resectable Colorectal Liver Metastases
This single-arm study will evaluate the resection rate of liver metastases in patients with metastatic colorectal cancer and borderline unresectable liver metastases receiving treatment with bevacizumab in combination with…
- Trial name
- CBL (NCT03711240)
- Testing
- bevacizumab, Oxaliplatin, Irinotecan
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Liver Cancer, Advanced Solid Tumors
Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin
PRIMARY: To determine the toxicity and tolerability of intra-arterial hepatic oxaliplatin every three weeks administered in combination with systemic intravenous Fluorouracil, Leucovorin and bevacizumab to patients with advanced…
- Trial name
- NCT00507585
- Testing
- Fluorouracil, Avastin, Leucovorin
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- M.D. Anderson Cancer Center
Liver Metastases, Colorectal Cancer Metastatic
Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis
The objective of this study is to evaluate the efficacy and safety of cryoablation combined with Sintilimab plus regorafenib for patients with colorectal cancer liver metastasis in the third-line setting.
- Trial name
- NCT05057052
- Testing
- Sintilimab, Regorafenib, US/CT-guided Percutaneous Cryoablation
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fudan University
Colorectal Cancer, Metastatic Cancer
Oxaliplatin and Capecitabine With or Without an Hepatic Arterial Infusion With Floxuridine in Treating Patients Who Are Undergoing Surgery and/or Ablation for Liver Metastases Due to Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, capecitabine, and floxuridine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00268463
- Testing
- capecitabine, floxuridine, oxaliplatin
- Where
- 31 sites in United States
- Volunteers
- 22 people
- Sponsor
- NSABP Foundation Inc
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