Clinical trials: Metastasis to Liver
Metastatic Colorectal Cancer
Modelle 001, TS-inhibition in Colorectal Liver Metastases Comparing Arfolitixorin and Calciumfolinate
A study that is blinded to the patient and the investigator where the combination of Arfolitixorin + 5-FU is compared to Calciumfolinate + 5-FU.
- Trial name
- NCT04126655
- Testing
- Arfolitixorin
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region
Metastatic Cancer, Melanoma
Evaluation of Pathway Modulation by Raf, MEK, & Kinase Inhibitors
This is a pilot study designed to evaluate the cutaneous effect of systemic inhibition of the tyrosine kinase pathway in the presence or absence of solar simulated light exposure.
- Conditions
- Metastatic Cancer, Melanoma, Colon Cancer, Differentiated Thyroid Cancer
- Trial name
- NCT03176485
- Testing
- Solar Simulator
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Arizona
Hepatocellular Carcinoma
A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer
In this study, researchers want to learn about the safety of a new drug, BAY 3547926, and how well the drug works in people with a type of liver cancer called advanced hepatocellular carcinoma (HCC), which has a special protein…
- Trial name
- BANTAM-01 (NCT06764316)
- Testing
- BAY 3547926, BAY 3547922, BAY 3713391
- Where
- 36 sites in United States, Belgium and 7 more
- Volunteers
- 148 people
- Sponsor
- Bayer
Rectal Cancer, Liver Metastasis
Short Course Radiotherapy Followed Intensive Chemotherapy With Delayed Surgery for Rectal Cancer With Synchronous Distant Metastasis
Radical treatment of primary rectal cancer with synchronous distant metastases includes surgical resection of primary and metastatic lesion.
- Conditions
- Rectal Cancer, Liver Metastasis, Lung Metastasis
- Trial name
- NCT01923987
- Testing
- Short Course Radiotherapy, Chemotherapy, Delayed Surgery
- Where
- 2 sites in South Korea
- Volunteers
- 39 people
- Sponsor
- Korea Cancer Center Hospital
Metastatic Colorectal Cancer
Atezolizumab Monotherapy vs Atezolizumab Plus Cobimetinib in Liver Metastases From Colorectal Cancer
This study is for patients with metastatic colorectal cancer who are candidates for resection of metastases. This study will be conducted sequentially with 2 cohorts: 1.) Monotherapy Cohort and 2.) Combination Cohort…
- Trial name
- ATELIER (NCT03340558)
- Testing
- Atezolizumab, Cobimetinib
- Where
- United States
- Sponsor
- Niharika Mettu
Primary Liver Cancer, Metastatic Liver Cancer
Improving CBCT for Liver IG-SBRT Using Gadoxetate Disodium
This is a feasibility study requiring only three patients to serve as a proof of concept that gadoxetate disodium (a liver specific contrast agent) can be used to improve images taken just before liver SBRT treatments.
- Trial name
- NCT03215355
- Testing
- Primovist
- Where
- Canada
- Sponsor
- Slawa Cwajna
Gastrointestinal Neoplasm
Primary Tumour Response to Induction Chemotherapy in Synchronously Metastasized Colorectal Cancer
We performed a retrospective data analysis of patients with synchronously metastasized colorectal cancer, comparing the histological response on the primary tumour to chemotherapy combined with either vascular endothelial growth…
- Trial name
- NCT05172635
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Klinik Favoriten
Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma
Radiation Therapy in Preventing Liver Metastases in Patients With Uveal Melanoma Who HaveMonosomy 3 or DecisionDx Class 2 Disease and Are More Likely to Develop Liver Metastases
This clinical trial studies giving radiation therapy to the liver in patients with uveal (eye) melanoma who have a specific chromosome loss (monosomy 3) or are DecisionDx Class 2 and therefore more likely to have their disease…
- Conditions
- Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma, Stage IIA Uveal Melanoma, Stage IIB Uveal Melanoma
- Trial name
- NCT02336763
- Testing
- External Beam Radiation Therapy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Hepatobiliary Cancer, Pancreatic Cancer
Impact of Comprehensive Geriatric Management on Morbidity and Quality of Life in Elderly Patients Undergoing Major Hepatectomy and Pancreaticoduodenectomy for Cancer
The worldwide incidence of hepatobiliary and pancreatic (HPB) cancers is dramatically increasing especially for pancreatic cancer. Increasing age is associated with increased cancer risk.
- Trial name
- HPB70+ (NCT06999512)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 12 sites in France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer, Metastatic Cancer
Fludeoxyglucose F 18-PET Imaging for Early Detection of Residual Disease in Patients Undergoing Radiofrequency Ablation of Liver Metastases From Colorectal Cancer
RATIONALE: Diagnostic procedures, such as fludeoxyglucose F 18-PET imaging, may be effective in detecting residual disease after radiofrequency ablation of liver metastases in patients with colorectal cancer.
- Trial name
- NCT00499395
- Testing
- positron emission tomography, radiofrequency ablation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Ocular Melanoma, Uveal Melanoma
Percutaneous Hepatic Perfusion in Patients With Hepatic-dominant Ocular Melanoma
This study will evaluate patients who have ocular melanoma that has spread from the eye to the liver: Patients in the study will be treated with Melphalan/HDS up to 6 total treatments and will be followed until death.
- Trial name
- FOCUS (NCT02678572)
- Testing
- Melphalan/HDS
- Where
- 22 sites in United States, Austria and 7 more
- Volunteers
- 102 people
- Sponsor
- Delcath Systems Inc.
Colorectal Neoplasms, Drug Therapy
Neoadjuvant FOLFOXIRI Chemotherapy in Resectable Liver Metastasis of Colorectal Cancer
To evaluate the efficacy and safety of neoadjuvant FOLFOXIRI chemotherapy (irinotecan, oxaliplatin and fluorouracil) in the patients with resectable liver metastasis of colorectal cancer
- Trial name
- NCT03487939
- Testing
- FOLFOXIRI
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China Medical University, China
Digestive Neuroendocrine Tumors, Metabolic Radiotherapy
Metabolic Radiotherapy After Complete Resection of Liver Metastases in Patient With Digestive Neuroendocrine Tumor
TERAVECT is a phase III randomized study of patients with digestive neuroendocrine tumors after complete surgical resection of liver metastases treated with In111-Pentetreotide-based adjuvant radiotherapy.
- Conditions
- Digestive Neuroendocrine Tumors, Metabolic Radiotherapy, Resection, Liver Metastases
- Trial name
- TERAVECT (NCT02465112)
- Testing
- In111-Pentetréotide, simple monitoring without active therapy
- Where
- 5 sites in France
- Volunteers
- 4 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Portal Vein Thrombosis, Local Cause
Risk Factors for Recurrence of Thrombosis or Thrombotic Extension, in the Event of Acute Non-cirrhotic Portal Vein Thrombosis Secondary to a Local Cause.
In case of acute portal vein thrombosis (PVT) prothrombotic factors are identified in about 60% of cases, while a local condition is present in 30% of cases.
- Trial name
- LOCAPORT (NCT05360641)
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Caen
Colorectal Cancer
Evaluation of the Efficacy and Safety of Bevacizumab Combined With PD-1 Monoclonal Antibody in Preoperative Neoadjuvant Therapy for MSS Colorectal Cancer With Liver Metastases
Evaluation of the Efficacy and Safety of Bevacizumab Combined With PD-1 Monoclonal Antibody in Preoperative Neoadjuvant Therapy for MSS Colorectal Cancer With Liver Metastases - a Single-center, Single-arm, Open-label Clinical…
- Trial name
- NCT06124729
- Testing
- Bevacizumab Combined With PD-1 Monoclonal Antibody
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colorectal Cancer, Colorectal Liver Metastasis
Prehabilitation in Liver Surgery
Each year in the UK around 1500 patients undergo surgery for bowel cancer that has spread to the liver. This is major surgery that offers a chance of cure, but can be associated with complications.
- Conditions
- Colorectal Cancer, Colorectal Liver Metastasis, Liver Surgery, Exercise Intervention
- Trial name
- NCT01523353
- Testing
- Exercise Intervention
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Colorectal Cancer
FOLFOXIRI Plus Panitumumab Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only
In this Phase II study the investigators plan to determine the overall response rate (ORR) of the combination of FOLFOXIRI plus panitumumab as first-line treatment of patients with liver-only metastatic KRAS wild-type colorectal…
- Trial name
- NCT01226719
- Testing
- Panitumumab, Oxaliplatin, Irinotecan
- Where
- 15 sites in United States
- Volunteers
- 15 people
- Sponsor
- SCRI Development Innovations, LLC
Metastatic Colorectal Cancer, Liver Metastases
Optimal Control of Liver Metastases From Colorectal Cancer With Cetuximab and Hepatic Artery Infusion of Chemotherapy
The primary objective of the study is to increase by 15% the complete macroscopic resection rate of predominantly liver metastases from metastatic colorectal cancer through combining systemic cetuximab and hepatic artery infusion…
- Conditions
- Metastatic Colorectal Cancer, Liver Metastases, Hepatic Lesions
- Trial name
- OPTILIV (NCT00852228)
- Testing
- IV cetuximab, HAI chronomodulated chemotherapy, HAI conventional chemotherapy
- Where
- 14 sites in Belgium, France and 2 more
- Volunteers
- 60 people
- Sponsor
- Association pour la Recherche sur le Temps Biologique et la Chronothérapie
Pancreatic Cancer Metastatic
Conversion Surgery Vs. Palliative Care in Pancreatic Cancer Oligometastatic to the Liver
This study investigates the impact of surgical resection compared to palliative care in patients with oligometastatic pancreatic cancer limited to the liver.
- Trial name
- SONAR (NCT06690528)
- Testing
- Surgical resection of both the primary tumor and liver metastases
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Azienda Ospedaliera di Padova
Liver Metastases, Colorectal Cancer
Chemoembolisation With CPT11 Loaded DC Bead With Cetuximab and 5FU/LV in First Line in Patients With KRAS Wildtype mCRC
The purpose of this study is to assess feasibility of chemoembolization with DC Bead loaded with Irinotecan in combination with Cetuximab and 5FU/LV as a first line treatment for wildtype KRAS unresectable liver metastases from…
- Trial name
- NCT01631539
- Testing
- DC Bead™, Cetuximab, 5 FU
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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