Clinical trials: Metastasis to Lymph Node
Thyroid Cancer, Lymph Node
UNN-RADS Scale for Diagnosing Lymph Node Metastasis in Patients With History of Thyroid Cancer
In 2020, Sarda-Inman et al., developed the Ultrasound Neck Node Reporting and Data System (UNN-RADS) scale that allows decision-making about when it is appropriate to perform FNA of a cervical lymph node, evaluating seven…
- Trial name
- NCT06124469
- Testing
- US-guided fine needle aspiration (FNA)
- Where
- Mexico
- Volunteers
- 99 people
- Sponsor
- Instituto Mexicano del Seguro Social
Testis Cancer, Germ Cell Tumor
Role of Axumin PET Scan in Germ Cell Tumor
Investigators will use Axumin PET/CT to help with the imaging modalities to determine the presence of occult retroperitoneal disease.
- Conditions
- Testis Cancer, Germ Cell Tumor, Testicular Cancer, Germ Cell Tumor of Testis
- Trial name
- TESTPET (NCT03426865)
- Testing
- Axumin PET scan
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Pancreas Cancer, Pancreas Adenocarcinoma
Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer
Lymph node metastases are a strong prognostic predictor for pancreatic cancer. Para-aortic lymph nodes (PALN) are the final nodes for periampullary cancers before the cancer cells enter the systemic lymphatic circulation.
- Conditions
- Pancreas Cancer, Pancreas Adenocarcinoma, Lymph Node Metastasis
- Trial name
- PALN (NCT06065891)
- Testing
- PALN resection
- Where
- 6 sites in Denmark, Sweden
- Volunteers
- 300 people
- Sponsor
- Jon Unosson
NSCLC, Non Small Cell Lung Cancer
Radical Resection With Contralateral Lymph Node Dissection for Clinical N3 NSCLC
*Study Overview This study is investigating a surgical approach for patients with a serious type of lung cancer known as non-small cell lung cancer (NSCLC), particularly those in an advanced stage where cancer has spread to both…
- Trial name
- NCT07003490
- Testing
- Radical Resection with Bilateral Lymph Node Dissection
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Sentinel Lymph Node, Colorectal Cancer
Sentinel Lymph Node (SLN) in Colorectal Carcinoma (CRC) With a Near-infrared (NIR)-Dye
The sentinel lymph node (SLN) procedure is a standard staging technique in several types of cancer. One of the major problems of SLN mapping in colorectal cancer is the lack of an optimal dye and technique for identification of…
- Conditions
- Sentinel Lymph Node, Colorectal Cancer, Metastasis
- Trial name
- NCT02122523
- Testing
- Near-Infrared (NIR) dye Indocyanin Green (ICG)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Amsterdam UMC, location VUmc
Papillary Thyroid Carcinoma
Multimodal Deep Learning for Lymph Node Metastasis in Thyroid Cancer
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy in clinical practice, accounting for approximately 85% of all thyroid malignancies.
- Trial name
- NCT07299318
- Testing
- not intervention
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- West China Hospital
Hepatocellular Carcinoma, Radiotherapy, Sorafenib
Phase II Study of Concurrent Sorafenib and Intensity-modulated Radiotherapy (IMRT) for Advanced Hepatocellular Carcinoma
This is a single-arm phase II clinical trial to investigate the efficacy and toxicity of concurrent sorafenib and intensity-modulated radiotherapy (IMRT) for advanced hepatocellular carcinoma with portal vein or hepatic vein…
- Trial name
- SIRAHCC (NCT03535259)
- Testing
- concurrent sorafenib and IMRT, followed sorafenib maintenance
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Prostate Cancer
Choline PET/CT vs. MeAIB PET/CT in Prostate Cancer
Prostate cancer is currently the leading newly diagnosed cancer in the industrialized world. Treatment of prostate cancer is highly dependent on the stage of the disease.
- Trial name
- NCT02232672
- Testing
- Choline PET/CT and MeAIB PET/CT
- Where
- Denmark
- Sponsor
- Odense University Hospital
Metastatic Malignant Neoplasm in Lymph Node, Prostate Ductal Adenocarcinoma
Antiandrogen Therapy With or Without Axitinib Before Surgery in Treating Patients With Previously Untreated Prostate Cancer With Known or Suspected Lymph Node Metastasis
This randomized phase IIA trial studies how well antiandrogen therapy works with or without axitinib before surgery in treating patients with previously untreated prostate cancer that is known or suspected to have spread to lymph…
- Conditions
- Metastatic Malignant Neoplasm in Lymph Node, Prostate Ductal Adenocarcinoma, Stage III Prostate Adenocarcinoma AJCC v7, Stage IV Prostate Adenocarcinoma AJCC v7
- Trial name
- NCT01409200
- Testing
- Antiandrogen Therapy, Axitinib, Radical Prostatectomy
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer, Molecular Imaging
Novel Humanized Ferritin-Based NIR Fluorescent Probe for Identifying Sentinel Lymph Node Metastasis in Early Gastric Cancer
With the widespread adoption of early cancer screening, the proportion of early gastric cancer (EGC) in China has been gradually increasing. The primary treatments for EGC are endoscopic and surgical interventions.
- Trial name
- NCT07294638
- Testing
- VE/CX-FTn-ICG injection solution
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Breast Cancer, Artificial Intelligence
Prediction of Non-sentinel Lymph Node Metastatic Status of Breast Cancer Based on Pathology-MRI Images
The goal of this observational study is to develop an artificial intelligence model based on pathology and magnetic resonance imaging (MRI) images to predict the metastatic status of non-sentinel lymph nodes in patients with…
- Conditions
- Breast Cancer, Artificial Intelligence, Lymph Node Metastasis, Digital Pathology
- Trial name
- NCT06510738
- Volunteers
- 700 people
- Sponsor
- Yunnan Cancer Hospital
Cancer, Malignant Melanoma
Effect of rIL-21 on Metastases in Lymph Nodes in Melanoma Skin Cancer
The trial is conducted in Europe. This trial aims for a comparison of the pathology in lymph nodes before and after the effect of recombinant interleukin-21 in patients with stage III melanoma
- Trial name
- NCT00601861
- Testing
- recombinant interleukin-21
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Novo Nordisk A/S
Esophageal Cancer
Esophagectomy in Middle and Lower Thoracic Esophageal Cancer Patients Through Left Versus Right Transthoracic Approach
Esophageal carcinoma is an aggressive malignant disease with poor prognosis. Surgical resection remains the most effective method for this malignancy.
- Trial name
- NCT02448979
- Testing
- Left thoracotomy, Right thoracotomy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese Academy of Medical Sciences
Cancer T1-N0 or T2-N0 of the Oral Cavity
Sentinel. Ambulatory. Oral Cavity. Oropharynx (S.A.C.O)
This is a single-center pilot study of open-label, non-randomized interventional research based on the outpatient management of 30 patients with T1-N0 or T2-N0 cancer in the oral cavity or oropharynx.
- Trial name
- SACO (NCT03545256)
- Testing
- outpatient surgery for T1-N0 or T2-N0 cancers of the oral cavity or oropharynx with lymph node search
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Early Gastric Cancer, Lymph Node Metastases
Verifying the Specificity of a New Method in Predicting Lymph Node Metastasis in Early Gastric Cancer Patients
Early gastric cancer is defined as gastric cancer that only invades mucosal or submucosal layer. The 5-year survival rate of gastric cancer can exceed 90% due to appropriate treatment.
- Trial name
- NCT03632746
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhaode Bu, MD
Melanoma
Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases
This study will evaluate the clinical and pathological response to vemurafenib and cobimetinib in the neoadjuvant treatment of patients with histologically confirmed, BRAF V600 mutation-positive Stage IIIB and C melanoma.
- Trial name
- NCT02036086
- Testing
- Vemurafenib, Cobimetinib
- Where
- 3 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Differentiated Thyroid Cancer (DTC), Robotic Assistance
Robotic Surgery Via Bilateral Axillo-breast Approach for Relatively Low-risk Papillary Thyroid Carcinoma With Lateral Cervical Lymph Node Metastasis: a Safe and Effective Cosmetic Procedure in the Context of Prevalent Thyroid Ultrasound Screening
The goal of this observational study is to learn the efficacy, cosmetic effectiveness and safety of robotic modified radical neck dissection in well-selected cases, through direct comparison with conventional open surgery in…
- Trial name
- NCT07229859
- Where
- China
- Volunteers
- 332 people
- Sponsor
- Ruijin Hospital
Esophageal Neoplasms, Lymph Node Metastases
Distribution of Lymph Node Metastases in Esophageal Carcinoma
Background: Lymph node status is an important prognostic parameter in esophageal carcinoma and an independent predictor of survival.
- Trial name
- TIGER (NCT03222895)
- Where
- 19 sites in United States, Brazil and 12 more
- Volunteers
- 5,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Prostate Cancer
Evaluation of dAroLutamide Addition to anDrogen Deprivation Therapy and radIatioN Therapy in Newly Diagnosed Prostate Cancer With Pelvic Lymph Nodes Metastases
Prospective, multicenter, comparative, randomized placebo-controlled Phase III trial - patients with hormone-naïve prostate cancer and pelvic lymph nodes metastases
- Trial name
- ALADDIN (NCT05116475)
- Testing
- Darolutamide 300 mg
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
Prostate Cancer
Phase III Clinical Trial to Evaluate INR101 Injection for PET/CT Imaging in Patients With Prostate Cancer.
A multicenter, open-label, prospective Phase III clinical trial to evaluate INR101 injection for PET/CT imaging in patients with Prostate Cancer
- Trial name
- NCT06922903
- Testing
- INR101
- Where
- 32 sites in China
- Volunteers
- 240 people
- Sponsor
- Yunhe Pharmaceutical (Tianjin) Co., Ltd