Clinical trials: Metastasis to Vertebral Column
Thoracic Cancer, Spine Cancer
Studying a New Piece of Equipment That Can Help Plan Radiation Therapy of the Spine
Participants will receive an MRI with a custom-built MRI coil for each participant. The purpose is to find out whether this custom-built MRI coil can help doctors see the different parts of the spine as well as or better than…
- Conditions
- Thoracic Cancer, Spine Cancer, Thoracic Diseases, Spine Disease
- Trial name
- NCT04227717
- Testing
- MRI with custom MRI spine coil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Spinal Metastases, Bone Metastases
Randomized Trial Comparing Conventional Radiotherapy With Stereotactic Radiotherapy in Patients With Bone Metastases - VERTICAL Study
The purpose of the study is to investigate effectiveness of stereotactic body radiotherapy in patients with bone metastatic disease.
- Trial name
- VERTICAL (NCT02364115)
- Testing
- Stereotactic Body Radiotherapy
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- UMC Utrecht
Metastases to Bone
Pilot Randomized Study for Treatment Volume De-Escalation for Spinal Metastases With Stereotactic Body Radiation Therapy
A single centre, non-profit, randomised, unblinded pilot study on volume definition for spinal stereotactic body radiation therapy treatment. Randomization will be 1:1 between two types of SBRT treatment for spinal metastases.
- Trial name
- REVOL-SPINE (NCT07538024)
- Testing
- Stereotactic Body Radiation Therapy (SBRT) in control arm, Stereotactic Body Radiation Therapy (SBRT) in experimental arm
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Spine Metastasis
A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
- Trial name
- NCT03072979
- Testing
- Stereotactic body radiotherapy
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Metastatic Cancer, Metastatic Lung Cancer
Definitive Radiation for High-Risk Spine Metastases
This study is looking at whether patients with cancer that has aggressively spread to the spine can be treated with stereotactic body radiation therapy only and avoid a large spine surgery
- Conditions
- Metastatic Cancer, Metastatic Lung Cancer, Metastatic Breast Cancer, Metastatic Tumor
- Trial name
- NCT06165419
- Testing
- SBRT to the spine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Stony Brook University
Spinal Metastasis
Combining Intraoperative Radiotherapy With Kyphoplasty for Treatment of Spinal Metastases
The primary objective is to evaluate the tolerability (side effects) of the intraoperative radio therapy (IORT) (e.g., wound healing, infections, bone necrosis, nerve, spinal cord damage, and pathological fracture), and the…
- Trial name
- KYPHO-IORT (NCT02480036)
- Testing
- IORT with Kyphoplasty, Intrabeam®
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Loyola University
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Bone Cancer Metastatic, Radiofrequency Ablation
Effectiveness Of Radiofrequency Ablation And Stabilization In Metastatic Spine Lesions By Positron Emission Computed Tomography (PET-CT) Confirmation
This pilot study will try to demonstrate metabolic changes in spine lesions treated by Augmentation and Ablation, according to existing standards of practice.
- Conditions
- Bone Cancer Metastatic, Radiofrequency Ablation, Spine Metastases, Vertebral Metastasis
- Trial name
- ABLASPINE (NCT06716294)
- Testing
- Radiofrequency Ablation and Bone Augmentation
- Where
- Greece
- Volunteers
- 16 people
- Sponsor
- National and Kapodistrian University of Athens
Spine Metastasis
A Phase II Trial Evaluating Radiation Boost to Painful Spinal Metastases
Spine SBRT is considered a standard of care for the treatment of spinal metastases. Compared to conventional radiation therapy, spine SBRT delivers high doses of radiation to the affected areas to the spinal metastases.
- Trial name
- OPTIMAL (NCT07478289)
- Testing
- Radiation Boost
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Sunnybrook Health Sciences Centre
NSCLC
SBRT Versus Conventional Fractionated Radiotherapy for Vertebral Metastases
Vertebral metastases are events that affect the quality of life of tumor patients, and are often accompanied by severe pain at the site of metastasis and even by the risk of compression fracture.
- Trial name
- NCT05577052
- Testing
- Metastatic vertebrae treated with SBRT
- Volunteers
- 100 people
- Sponsor
- Wuhan University
To Evaluate Performance of the DLS
Validation of a Multitask Deep Learning System at Spine Metastasis CT
15 resident oncologists were conducted to evaluate the clinical efficacy of DLS in multicenter. They were 1:1 randomly asked to independently read the test images without the assistance of DLS software or with the assistance.
- Trial name
- NCT05156567
- Testing
- Deep Learning System
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai 6th People's Hospital
Solid Tumor Spine Metastases
Radiotherapy for Solid Tumor Spine Metastases
Although it is being increasingly used off protocol, there is minimal data regarding the efficacy of stereotactic radiosurgery to the tumor bed following surgical resection of metastatic lesions to the spine.
- Trial name
- NCT01752036
- Testing
- Post-operative, Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Solid Tumor, Spinal Neoplasms
Separation Surgery Followed by Stereotactic Ablative Body Radiotherapy (SABR) Versus SABR Alone for Spinal Metastases
This is a non-inferiority, randomised controlled trial to investigate the effect of stereotactic ablative body radiotherapy (SABR) compared to separation surgery followed by SABR in ambulatory patients with malignant epidural…
- Conditions
- Solid Tumor, Spinal Neoplasms, Spinal Tumor
- Trial name
- SABR-MESCC (NCT06613295)
- Testing
- SABR, Separation surgery
- Where
- 9 sites in Belgium
- Volunteers
- 128 people
- Sponsor
- Cancer Research Antwerp
Metastasis Spine, Metastasis to Bone
OsteoCool Tumor Ablation Post-Market Study
This study evaluates the effectiveness of the Medtronic OsteoCool™ RF Ablation System.
- Trial name
- OPuS One (NCT03249584)
- Testing
- OsteoCool™ RF Ablation
- Where
- 16 sites in United States, Canada and 3 more
- Volunteers
- 218 people
- Sponsor
- MedtronicNeuro
Spinal Metastases
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS.
- Trial name
- NCT06173401
- Testing
- Single-fraction spine SRS, Multi-fraction spine SRS
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Stanford University
Spine Metastases
Minimally Invasive Surgery (MIS) for Spine Metastases
The purpose of this study is to collect information on the effect of minimally invasive spine tumor decompression on treated patients.
- Trial name
- NCT02367378
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Metastases, Spinal Tumor
The Effect of Radiotherapy After Separation Surgery for Spinal Metastases
The aim of this clinical study is to explore the impact of whether radiotherapy is administered after spinal metastasis surgery on the prognosis and survival of patients, to describe the clinical outcomes, and to optimize future…
- Conditions
- Spinal Metastases, Spinal Tumor, Radiotherapy, Separation Surgery
- Trial name
- NCT07527884
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Wei Xu
Metastatic Spinal Cord Compression, Metastasis Spine
Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease
Background: Spinal metastatic disease constitute a serious clinical problem in oncology. Bones are the third most common organ where metastases are located, and the spine is the place where they are most often located.
- Trial name
- CarboMetaspine (NCT06293157)
- Testing
- Transpedicular spinal stabilization - carbon fibers-based implants, Transpedicular spinal stabilization - titanium implants, Stereotactic body radiotherapy
- Where
- 5 sites in Poland
- Volunteers
- 226 people
- Sponsor
- Copernicus Memorial Hospital
Spinal Metastases
Corpectomy With Pyramesh Titanium Cage Reconstruction in Dorsolumber Metastatic Lesions
The vertebral column represents the most common bony site for metastasis with an incidence ranged from 30% to 70% in patients with metastatic neoplasms.
- Trial name
- NCT03768167
- Testing
- Posterolateral corpectomy
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sohag University
Spinal Diseases, Spinal Metastases
Intra-arterial Chemotherapy for Spinal Metastases
Metastatic malignant tumors comprise the vast majority of spinal tumors in adults. The most devastating complication of spinal metastatic disease (SMD) is invasion of the spinal canal and compression of the spinal cord or the…
- Conditions
- Spinal Diseases, Spinal Metastases, Spinal Tumors
- Trial name
- SIAC (NCT01637766)
- Testing
- Melphalan (intra-arterial infusion)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University