Clinical trials: Metastasis to Vertebral Column
Secondary Malignant Neoplasm of Spine
Involved Versus Elective Target SSRS for Spinal Metastases
The spine is a common metastatic site for malignancy and it can lead to serious and devastating events, including pain, neurological dysfunction, and reduction in quality of life.
- Trial name
- NCT04033536
- Testing
- Involved Target Stereotacic Spine Radiosurgery, Elective Target Stereotacic Spine Radiosurgery
- Where
- Taiwan
- Volunteers
- 114 people
- Sponsor
- National Taiwan University Hospital
Spinal Metastases
Outcomes of Surgical Treatment of Patients With Spinal Metastasis in AUH
To analyze the outcomes of surgical treatment of patients with spinal metastases in spine unit in AUH regarding the pain control, neurological status and ambulatory status as well as survival rate .
- Trial name
- NCT04110457
- Testing
- spinal decompression
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Spine Metastases
Post Operative RT for Limited Spine Metastases
To evaluate patients with limited spine metastases treated with total spondylectomy followed by conventional radiotherapy or debulking surgery followed by SBRT or conventional RT.
- Trial name
- NCT05495399
- Testing
- Spondylectomy, SBRT
- Where
- Taiwan
- Volunteers
- 111 people
- Sponsor
- National Taiwan University Hospital
Stereotactic Body Radiation Therapy (SBRT), Spinal Metastases
Efficacy and Safety of Stereotactic Body Radiation Therapy for Spinal Metastases With Bilsky Grade 1c-3
This prospective, multicenter, single-arm phase II clinical trial is designed to enroll patients with spinal metastases classified as Bilsky grade 1c-3 who will receive stereotactic body radiation therapy (SBRT).
- Trial name
- NCT07809672
- Testing
- SBRT
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Spinal Metastases
Intraoperative Radiotherapy in Treating Spinal Metastases
In order to provide theoretical evidence for the comprehensive and standardized treatment of spinal metastases with pathological fractures and/or spinal cord compression, the investigators conduct this trial to investigate the…
- Trial name
- NCT06093854
- Testing
- Intraoperative radiotherapy (IORT), Stereotactic body radiotherapy (SBRT)
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shanghai Changzheng Hospital
Cancer, Spine Metastasis
A Pilot Study to Explore Serum and Imaging Biomarkers in Patients With Spinal Cord Compression
One of the complications of having cancer in the spinal vertebrae is that it can spread and lead to compression of the spinal cord.
- Trial name
- NCT00928382
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Spinal Metastases
Validation of Novel Predictive Score for Patients With Spinal Metastases
The investigators are prospectively validating a prognostic clinical tool that uses a patient's modified Bauer grade, ambulatory status, and pre-operative serum albumin to predict survival, post-treatment morbidity, and…
- Trial name
- NCT03224650
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Brigham and Women's Hospital
Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System
Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases
The goal of this clinical research study is to learn whether delivering spine radiosurgery in a single large dose is better than delivering spine radiosurgery over 3 smaller doses.
- Trial name
- NCT03028337
- Testing
- Spine Radiosurgery, Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Minimally Invasive Surgery, Spinal Metastases
Robot-assisted Invasion-controlled Surgery Versus Traditional-open Surgery Against Metastatic Spinal Tumor
With significant advances in diagnostic imaging and systemic therapies for oncologic disease, spinal metastasis with neurological dysfunction and mechanical instability has become an indication for surgery.
- Trial name
- NCT05173467
- Testing
- Robot-assisted Invasion-controlled Surgery, Traditional-open Surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wei Xu
Metastatic Spinal Tumors, Spinal Cord Compression
Postoperative Neurological Recovery and Risk Factor Analysis in Patients With Paralysis Due to Spinal Metastases
Metastatic spinal tumors represent a common and devastating complication in patients with advanced solid malignancies. Up to 40% of cancer patients may develop spinal metastases during the course of their disease, often resulting…
- Conditions
- Metastatic Spinal Tumors, Spinal Cord Compression, Paralysis, Neurological Deficits
- Trial name
- NCT07527728
- Volunteers
- 150 people
- Sponsor
- Shanghai Changzheng Hospital
Secondary Malignant Neoplasm of Vertebral Column
The Epidemiology, Process and Outcomes of Spine Oncology (EPOSO)
The main purpose of this study is to utilize a comprehensive, prospective clinical database to collect patient, diagnostic and treatment variables along with disease specific and generic health related quality of life (HRQOL)…
- Trial name
- EPOSO (NCT01825161)
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 454 people
- Sponsor
- AO Foundation, AO Spine
Epiduritis, Vertebral Bone Metastasis
Stereotactic Radiotherapy for SPinal Metastases With Limited Extent of Epidural Disease
This study evaluates a new radiation treatment approach for patients with cancer that has spread to the spine (vertebral metastases) and involves limited extension around the spinal cord without causing compression…
- Trial name
- SPEED-RT (NCT07656883)
- Testing
- Stereotactic Body Radiotherapy (SBRT), Conventional External Beam Radiotherapy
- Where
- 14 sites in France
- Volunteers
- 167 people
- Sponsor
- Institut Cancerologie de l'Ouest
Spinal Metastasis
Clinical Trial Comparing Dose-intensified SBRT With Conventional Radiation Therapy for Spinal Metastases
This study will compare pain (primary end-point) and local metastatic tumor control (secondary end-point) after dose-intensified image-guided fractionated stereotactic body radiation therapy (SBRT) for painful mass-type spinal…
- Trial name
- DOSIS RCT (NCT02800551)
- Testing
- dose-intensified image-guided SBRT using simultaneous integrated boost, External 3-dimensional conformal radiotherapy (3D-CRT)
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- University of Zurich
Breast Cancer, Prostate Cancer
Potential Vertebroplasty Use in the Treatment of Vertebral Metastasis From Breast and Prostate Cancer
The study aims to evaluate if adding vertebroplasty to radiotherapy, in the treatment of spine metastasis from breast and prostate cancer, is preferable to radiotherapy alone.
- Conditions
- Breast Cancer, Prostate Cancer, Vertebral Metastasis, Pain
- Trial name
- NCT00294151
- Testing
- Vertebroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Osseous Spine Metastases
Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR)
A randomized phase III study of palliative external beam radiotherapy (RTOG 97-14) has shown that 8 Gy in a single fraction is very effective in providing pain relief, with complete or partial improvement in pain seen in 66% of…
- Trial name
- NCT00267033
- Testing
- injection of orthopaedic cement into vertebral bodies
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spine Metastasis, Stereotactic Body Radiation Therapy (SBRT)
Short Interval Postoperative Stereotactic Body Radiation Therapy (SBRT) After Surgical Intervention for Spine Metastases
Current guidelines suggest postoperative spine Stereotactic Body Radiation Therapy (SBRT) should be delivered within 2-4 weeks after surgery.
- Trial name
- NCT07346170
- Testing
- Stereotactic Body Radiation Therapy (SBRT), Computed Tomography (CT) Simulation, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Spinal Metastases
D20054;LITT for Spine Tumors
The objective of this clinical study is to evaluate the efficacy and safety of spinal laser interstitial therapy in the treatment of metastatic spinal tumors.
- Trial name
- NCT06548061
- Testing
- ClearPoint Prism
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Metastatic Neoplasm to the Spine, Metastatic Neoplasm
Spine Radiosurgery for Symptomatic Metastatic Neoplasms
The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic…
- Trial name
- SPORTSMEN (NCT05617716)
- Testing
- Conventional external beam radiation therapy dose (EBRT), Spine radiosurgery/stereotactic body radiation therapy standard dose, Spine radiosurgery/stereotactic body radiation therapy high dose
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Oklahoma
Solid Tumor Spine Metastases
Spine SABR - Dose-escalated Stereotactic Ablative Body Radiotherapy (SABR) for Solid Tumour Spine Metastases
This study will look at treatment for patients that have already been diagnosed with cancer, but develop a new tumor(s) in the spine.
- Trial name
- Spine-SABR (NCT06078813)
- Testing
- Radiation: image guided dose escalated SABR using a simultaneous integrated boost (SIB)
- Where
- 3 sites in Ireland
- Volunteers
- 126 people
- Sponsor
- Cancer Trials Ireland
Vertebral Metastasis
Spinery® A Novel Radio-Frequency Tumor Ablation Device for Spine Metastatic Tumors
The SPARTA study (Spinery® Radiofrequency Ablation Device Study) is a prospective, multicenter, single-arm clinical investigation designed to evaluate the safety, performance, and efficacy of the Spinery® RF Generator and its…
- Trial name
- SPARTA (NCT05467540)
- Testing
- Spinery System
- Where
- 5 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Axon srl