Clinical trials: Metastatic Colorectal Cancer (MCRC)
Colorectal Cancer Metastatic
Study of Durvalumab and Tremelimumab After Radiation for Microsatellite Stable Metastatic Colorectal Cancer Progressing on Chemotherapy
This study is being done to look at the safety and response to the combination of two investigational drugs, tremelimumab and durvalumab, when given after radiation therapy for patients with microsatellite stable (MSS) metastatic…
- Trial name
- NCT03007407
- Testing
- durvalumab, Tremelimumab
- Where
- 18 sites in United States
- Volunteers
- 33 people
- Sponsor
- NSABP Foundation Inc
Colorectal Neoplasms, Neoplasm Metastasis
A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC
The primary purpose of this study is to determine the non-inferiority of overall survival FOLFIRI with or without Bevacizumab compared with Irinotecan (CPT-11) with or without Bevacizumab as Second-line therapy in Patient with…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Intestinal Neoplasms, Gastrointestinal Neoplasms
- Trial name
- NCT03303495
- Testing
- Bevacizumab, CPT-11, 5-FU Bolus
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Sun Yat-sen University
Metastatic Colorectal Cancer (mCRC)
LPM6690176 in Combination With Chemotherapy and Bevacizumab in Metastatic Colorectal Cancer Patients With RAS Mutation
This study is consist of phase 1b (dose escalation + safety run-in) and phase 2 (randomized, controlled). Phase 1b is planned to evaluate the safety and tolerability of LPM6690176 capsule in combination with chemotherapy and…
- Trial name
- NCT07391566
- Testing
- LPM6690176, Bevacizumab, FOLFIRI (5-Fluorouracil, Folinic acid, Irinotecan)
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Luye Pharma Group Ltd.
mCRC
Evaluate the Efficacy of Irinotecan Versus Oxaliplatin in the First-line Treatment of Refractory Metastatic Colorectal Cancer
This is a prospective, open-lable, multicenter, randomized, controlled, phase II clinical study. The aim is to evaluate the efficacy of Irinotecan versus Oxaliplatin in the first-line treatment of refractory metastatic colorectal…
- Trial name
- NCT03567629
- Testing
- Irinotecan, Oxaliplatin
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University
Advanced Colorectal Cancer
Identification of New Patient Stratification Tools in MSS RAS mt mCRC
This is a translational, multicentre and multinational study. The aim of this study is to identify new patient stratification tools in microsatellite stable RAS mutant metastatic Colorectal Cancer
- Trial name
- COLOSSUS (NCT03699111)
- Where
- 10 sites in Germany, Ireland and 1 more
- Volunteers
- 29 people
- Sponsor
- Cancer Trials Ireland
Metastatic Colorectal Cancer
RAS Mutations in ctDNA and Anti-EGFR reINTROduction in mCRC (RASINTRO)
Some data have suggested a clinical survival benefit related to the reintroduction of anti-EGFRs therapy in patients with metastatic colorectal cancer (mCRC).
- Trial name
- RASINTRO (NCT03259009)
- Volunteers
- 73 people
- Sponsor
- Association des Gastroentérologues Oncologues
Solid Tumor
A Study of SI-B003, a PD-1/CTLA-4 Bispecific Antibody, in Patients With Advanced Solid Tumors
In phase Ia study, the safety and tolerability of SI-B003 in patients with recurrent or metastatic solid tumors will be investigated to determine the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) or maximum…
- Trial name
- NCT04606472
- Testing
- SI-B003
- Where
- 8 sites in China
- Volunteers
- 60 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Metastatic Colorectal Cancer (mCRC)
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α SrRNA in Treating Metastatic CRC Patients
This trial is a single-arm, open-label, exploratory first-in-human clinical study designed to evaluate the safety and tolerability of HNF4α srRNA injection in patients with locally unresectable or metastatic colorectal cancer…
- Trial name
- NCT06621173
- Testing
- HNF4α srRNA
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Changzheng Hospital
Colorectal Cancer Liver Metastases (CRLM), Metastatic Colorectal Carcinoma (mCRC)
Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases
Colorectal cancer is the third most common malignancy worldwide, and prognosis largely depends on how effectively metastatic disease is managed.
- Trial name
- EXELION (NCT07224724)
- Testing
- EXELION
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- City of Hope Medical Center
Metastatic Colorectal Cancer
Erlotinib and Chemotherapy for 2nd Line Treatment (Tx) of Metastatic Colorectal Cancer (mCRC)
The purpose of this study is to see if alternating chemotherapy with erlotinib increases tumor shrinkage in people with metastatic colorectal cancer.
- Trial name
- NCT00642746
- Testing
- Erlotinib, Fluorouracil, Leucovorin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- OHSU Knight Cancer Institute
Metastatic Colorectal Cancer
Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651/KEYNOTE-651)
The purpose of this study is to determine safety and tolerability and to establish a preliminary recommended Phase 2 dose (RP2D) for the following combinations: pembrolizumab plus binimetinib (Cohort A), pembrolizumab plus…
- Trial name
- NCT03374254
- Testing
- Pembrolizumab, Binimetinib, Oxaliplatin
- Where
- 14 sites in United States, Canada
- Volunteers
- 116 people
- Sponsor
- Merck Sharp & Dohme LLC
Colorectal Cancer Metastatic
SHR-1701 Combined with SHR2554 and BP102 for MCRC
Response to oncologic treatment in mCRC is currently limited.
- Trial name
- NCT06679673
- Testing
- SHR-1701, BP102, SHR2554
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fudan University
Advanced Solid Tumors
A Study of ASP1002 in Adults for Treatment of Solid Tumors
ASP1002 is being studied in people with tumors that have spread to nearby tissue (locally advanced) that cannot be removed by surgery (unresectable) or tumors that have spread to other parts of the body (metastatic).
- Trial name
- NCT05719558
- Testing
- ASP1002, Bevacizumab, Oxaliplatin
- Where
- 15 sites in United States
- Volunteers
- 798 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Metastatic Colorectal Cancer, Liver Metastases
FOLFIRI and Sunitinib in Metastatic Colorectal Cancer
This is an open label single arm prospective multicenter Phase II study in around 20 patients. The primary objective of this study is to evaluate whether the addition of sunitinib to FOLFIRI results in a significant reduction of…
- Trial name
- NCT00806663
- Testing
- sunitinib added to FOLFIRI
- Where
- 4 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Central European Society for Anticancer Drug Research
Metastatic Colorectal Cancer
Panitumumab in Combination With Irinotecan Chemotherapy as 2nd-line Therapy in Subjects With mCRC
The purpose of this study is to assess the objective response rate (ORR) when panitumumab is administered in combination with irinotecan as 2nd-line therapy in subjects with previously treated metastatic colorectal cancer (mCRC).
- Trial name
- NCT00475293
- Testing
- Panitumumab and CPT-11
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Metastatic Colorectal Cancer
Metastatic Colorectal Cancer. Real-World Data Analysis.
The Treatment Choices, Duration and Outcomes in Patients with Ras Wild Type (RAS WT) Metastatic Colorectal Cancer (mCRC). Retrospective, Multi-Center, Real-World Data Analysis
- Trial name
- RWD-mCRC-001 (NCT04757311)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,750 people
- Sponsor
- Istanbul Medeniyet University
Metastatic Colorectal Cancer
Safety and Efficacy Study of mFOLFOX-6 Plus Cetuximab for 8 Cycles Followed by mFOLFOX-6 Plus Cetuximab or Single Agent Cetuximab as Maintenance Therapy in Patients With Metastatic Colorectal Cancer and WT KRAS Tumours
The purpose of the study is to evaluate the efficacy and safety of the combination of mFOLFOX-6 plus cetuximab for 8 cycles followed by mFOLFOX-6 plus cetuximab or single agent (s/a) cetuximab as maintenance therapy in patients…
- Trial name
- MACRO-2 (NCT01161316)
- Testing
- mFOLFOX-6 + cetuximab until disease progression or early withdrawal., 8 cycles of mFOLFOX-6 + cetuximab, followed by cetuximab alone until disease progression or early withdrawal.
- Where
- Spain
- Volunteers
- 194 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Liver Metastases, Colorectal Neoplasms
Phase 3 Trial of Litx™ Plus Chemotherapy vs. Chemotherapy Only Treating Colorectal Cancer Patients With Recurrent Liver Metastases
The purpose of the study is to assess the overall survival and progression free survival of patients treated with Litx™ + chemotherapy versus chemotherapy alone in the treatment of Colorectal Cancer with recurrent liver…
- Conditions
- Liver Metastases, Colorectal Neoplasms, Neoplasm Metastasis, Neoplasm Recurrence, Local
- Trial name
- NCT00440310
- Testing
- Talaporfin sodium, Percutaneous placement of device in liver metastases, Interstitial light emitting diodes
- Where
- 57 sites in Austria, Bosnia and Herzegovina and 11 more
- Volunteers
- 483 people
- Sponsor
- Light Sciences Oncology
Metastatic Colorectal Cancer
Efficacy and Safety of the Prophylactic Use of Doxycycline +/- Vitamin K Cream
The aim of this Phase 2, two-arm, randomized, double blind placebo controlled study is to evaluate the efficacy of combination therapy of doxycycline and Vitamin K1 compared to doxycycline plus placebo for the prevention of…
- Trial name
- NCT01345526
- Testing
- Reconval K1 Cream, Reconval Cream
- Where
- 2 sites in Germany, Slovenia
- Volunteers
- 124 people
- Sponsor
- Universitätsmedizin Mannheim
Metastatic Colorectal Cancer
Phase II Trial of FOLFOXIGIL Versus FOLFOXIRI as First-line Therapy in Patients With mCRC
A randomized phase II trial of FOLFOXIRI in Combination With GM-CSF and IL-2 (FOLFOXIGIL) Versus FOLFOXIRI as First-line Treatment for Patients With Metastatic Colorectal Cancer.
- Trial name
- NCT03222089
- Testing
- Irinotecan, Oxaliplatin, Levoleucovorin
- Where
- China
- Sponsor
- Fujian Cancer Hospital