Clinical trials: Metastatic Colorectal Neoplasms
Colorectal Liver Metastasis, Liver Neoplasms
A Prospective Study of a Subharmonic-Aided Pressure Estimate Technology for Early Prediction of Response to Systemic Therapy in Colorectal Cancer Liver Metastases
Colorectal cancer is a common type of cancer that often spreads to the liver. When cancer spreads to the liver, treatment becomes very difficult. Many patients will undergo chemotherapy to shrink the tumor.
- Conditions
- Colorectal Liver Metastasis, Liver Neoplasms, Colorectal Neoplasms
- Trial name
- NCT07583381
- Testing
- SHAPE
- Volunteers
- 107 people
- Sponsor
- The First Hospital of Jilin University
NSCLC (Advanced Non-small Cell Lung Cancer), NSCLC (Non-small Cell Lung Cancer)
A Multicenter Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors.
This is a multicenter, open-label, randomized (1:1) trial designed to evaluate whether ctDNA-guided interruption of immune-checkpoint inhibitor (ICI) therapy provides comparable survival to standard of care (SoC) continuous ICI…
- Conditions
- NSCLC (Advanced Non-small Cell Lung Cancer), NSCLC (Non-small Cell Lung Cancer), NSCLC (Non-small Cell Lung Carcinoma), NSCLC
- Trial name
- SIGNAL-IO 301 (NCT07689812)
- Testing
- Signatera Genome ultra-sensitive ctDNA blood test
- Volunteers
- 920 people
- Sponsor
- Natera, Inc.
Refractory Metastatic Colorectal Cancer, Solid Tumor
Vorbipiprant (CR6086) / Balstilimab (AGEN2034) Combination in Stage IV Refractory pMMR - MSS CRC, and Other Metastatic GI Cancers
This Phase Ib/IIa study comprises a Main Study and a Study Extension. The Main Study has been designed according to a 3+3 Dose Escalation/dose Expansion design in refractory pMMR-MSS mCRC patients.
- Conditions
- Refractory Metastatic Colorectal Cancer, Solid Tumor, Metastatic Microsatellite-stable Colorectal Cancer, Mismatch Repair Protein Proficient
- Trial name
- NCT05205330
- Testing
- CR6086, AGEN2034
- Where
- 3 sites in Italy
- Volunteers
- 107 people
- Sponsor
- Rottapharm Biotech
Colorectal Cancer
Cabozantinib and Panitumumab to Treat KRAS Wild-Type Metastatic Colorectal Cancer
There will be three parts to this phase I study: 1) the Combination Dose Finding cohort; 2) the Combination Expansion cohort; and 3) the Monotherapy MET Amplified cohort.
- Trial name
- CaboMAb (NCT02008383)
- Testing
- Panitumumab, Cabozantinib
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- John Strickler, M.D.
Metastatic Colorectal Cancer
Study of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients
This is a Phase Ib study to evaluate the safety and preliminary anti-tumor activity of pembrolizumab in combination with pemetrexed with or without oxaliplatin in patients with chemo-refractory microsatellite stable (MSS)…
- Trial name
- NCT03626922
- Testing
- Pembrolizumab, Pemetrexed, Oxaliplatin
- Where
- 15 sites in United States
- Volunteers
- 33 people
- Sponsor
- NSABP Foundation Inc
Cancer, Metastatic, Cancer
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and…
- Conditions
- Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver
- Trial name
- NCT03452774
- Testing
- Clinical Trial Matching
- Where
- 68 sites in United States, Puerto Rico
- Volunteers
- 50,000 people
- Sponsor
- Massive Bio, Inc.
Colorectal Cancer, Pancreatic Cancer
Evaluation of Safety and Activity of an Anti-PDL1 Antibody (DURVALUMAB) Combined With CSF-1R TKI (PEXIDARTINIB) in Patients With Metastatic/Advanced Pancreatic or Colorectal Cancers
Colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) are the most common gastrointestinal cancers in Western countries and are both associated with significant morbidity and mortality.
- Conditions
- Colorectal Cancer, Pancreatic Cancer, Metastatic Cancer, Advanced Cancer
- Trial name
- MEDIPLEX (NCT02777710)
- Testing
- Pexidartinib, Durvalumab
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- Centre Leon Berard
Colorectal Cancer, Liver Metastases
Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver
Background: Many people with colorectal cancer get liver metastases. Standard treatment for this is a combination of chemotherapy drugs. Directing the chemotherapy to the liver may be effective.
- Conditions
- Colorectal Cancer, Liver Metastases, Colorectal Adenocarcinoma, Colorectal Cancer With Hepatic Metastases
- Trial name
- NCT03366155
- Testing
- Codman 3000 constant flow pump catheter, Panitumumab, FUDR-Dex
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer Metastatic
Regorafenib and Sintilimab in Combination with Electroacupuncture in MSS CRC
The aim of this clinical trial is to find out whether Regorafenib and Sintilimab in combination with electroacupuncture works in treating participants with microsatellite stable (MSS) advanced colorectal cancer who have failed…
- Trial name
- NCT06456515
- Testing
- Regorafenib and Sintilimab in combination with electroacupuncture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First People's Hospital of Changzhou
Metastatic Colorectal Cancer, BRAF V600E Mutation
Primary and Acquired Resistance to Targeted Treatment in BRAF V600E-mutated Metastatic Colorectal Cancer
This study prospectively investigates the molecular mechanisms of primary and acquired resistance to standard-of-care BRAF V600E-directed therapy in patients with metastatic colorectal cancer and aims to pre-clinically develop…
- Trial name
- PARTACER (NCT07617610)
- Testing
- Longitudinal translational sampling
- Where
- 13 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- Swiss Cancer Institute
Cancer Metastatic to Liver, Cancer Colorectal
Postoperative Exercise Training and Colorectal Cancer Liver Metastasis
Up to 25% of colorectal cancer (CRC) patients are diagnosed with liver metastases, which is the most common site of metastasis, already during the primary tumor diagnosis.
- Trial name
- POET-mCRC (NCT05579340)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Metastatic Colorectal Cancer
Aflibercept and Chemotherapy as First Line Treatment for Metastatic Colorectal Cancer Assessable With DCE-US (PULSAR).
The PULSAR trial is an international, investigator-initiated, single arm open-label phase II study. The aim of this study is to measure the clinical activity of the combination FOLFIRI-aflibercept in an homogeneous group of…
- Trial name
- PULSAR (NCT02173990)
- Testing
- Aflibercept-FOLFIRI
- Where
- 8 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Oscar Lambret
Metastatic Colorectal Cancer, Metastatic Cervical Cancer
Safety of Effivia®, a Bevacizumab Biosimilar
This is a post-marketing observational study aimed to evaluated the safety profile of Effivia®, a biosimilar of bevacizumab, in mexican patients with different types of cancer.
- Conditions
- Metastatic Colorectal Cancer, Metastatic Cervical Cancer, Non Squamous Non Small Cell Lung Cancer
- Trial name
- NCT06313268
- Testing
- Bevacizumab Biosimilar MB02
- Where
- 5 sites in Mexico
- Volunteers
- 83 people
- Sponsor
- Laboratorios Liomont
CRC (Colorectal Cancer)
PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer
PM8002 (BNT327) is a bispecific antibody targeting PD-L1 and VEGF. This is a phase II trial to evaluate the efficacy and safety of PM8002 in combination with chemotherapy in first line MSS or MSI-L/pMMR metastatic colorectal…
- Trial name
- NCT07133750
- Testing
- PM8002, Chemotherapy Regimen 1, Chemotherapy Regimen 2
- Where
- 11 sites in China
- Volunteers
- 100 people
- Sponsor
- Biotheus Inc.
Metastatic Colorectal Cancer
A Study With Neoadjuvant mFOLFOX7 Plus Cetuximab to Determine the Surgical Conversion Rate for Unresectable Colorectal Cancer With Metastases Confined to the Liver
FC-6 is a Phase II, multi-center clinical trial for patients with unresectable, wild-type K-RAS, colorectal cancer with metastases confined to the liver.
- Trial name
- NCT00803647
- Testing
- cetuximab, 5-FU, oxaliplatin
- Where
- 23 sites in United States
- Volunteers
- 20 people
- Sponsor
- NSABP Foundation Inc
Colorectal Neoplasms
A Korean Post-marketing Surveillance Study on Erbitux® in Patients With Metastatic Colorectal Cancer Refractory to Irinotecan-containing Treatment
After consultation with the Korean Health Authorities, the two Post-Authorization Safety Studies EMR 62202-509 (NCT01082315) and EMR 62241-508 (NCT01075828) were combined within one study protocol EMR 062202-551.
- Trial name
- NCT01082315
- Testing
- Erbitux (Cetuximab)
- Where
- South Korea
- Volunteers
- 730 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655)
RATIONALE: Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing.
- Trial name
- NCT00023868
- Testing
- FOLFIRI regimen, cisplatin, doxorubicin hydrochloride
- Where
- 9 sites in United States
- Sponsor
- American College of Radiology Imaging Network
Colorectal Cancer Liver Metastases, Colorectal Cancer
Aspirin in Colorectal Cancer Liver Metastases
The ASAC trial is a Scandinavian, multi-center, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose acetylsalicylic acid (ASA) can improve disease free survival in patients…
- Conditions
- Colorectal Cancer Liver Metastases, Colorectal Cancer, Liver Metastases
- Trial name
- ASAC (NCT03326791)
- Testing
- Acetylsalicylic acid
- Where
- 14 sites in Denmark, Norway and 1 more
- Volunteers
- 466 people
- Sponsor
- Oslo University Hospital
Peritoneal Diseases
ERAS® Guidelines Validation of CRS With or Without HIPEC
Enhanced recovery after surgery (ERAS®) pathways have been shown to considerably reduce complications, length of stay and costs after most of surgical procedures by standardised application of best evidence-based perioperative…
- Trial name
- NCT05185791
- Testing
- Pre-ERAS® phase (current clinical practice), Post-ERAS® implementation phase
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 288 people
- Sponsor
- Hospices Civils de Lyon
Colorectal Carcinoma
Axitinib as Maintenance Treatment in Patients With Metastatic CRC
The purpose of this study is to evaluate the maintenance therapy with axitinib in patients with metastatic colorectal carcinoma
- Trial name
- TTD-11-01 (NCT01483638)
- Testing
- axitinib
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.