Clinical trials: Metastatic Malignant Neoplasm in the Liver
HER-2 Positive Gastric Cancer, Liver Metastasis
Perioperative Chemotherapy With Herceptin For Potentially Resectable HER-2 Positive Gastric Cancer With Liver Metastasis
Stage I：preoperative therapy Capecitabine plus oxaliplatin with herceptin is superior to surgery alone for patients with potentially resectable HER-2 positive gastric cancer with liver metastasis; Stage II: Perioperative therapy…
- Trial name
- NCT02380131
- Testing
- Oxaliplatin plus Capecitabine, Herceptin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hebei Medical University
Cancer
Thalidomide and Docetaxel in Treating Patients With Advanced Cancer
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00049296
- Testing
- docetaxel, thalidomide
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Liver Metastases, Colorectal Carcinoma
An Evaluation of Tilmanocept by IV Injection Using SPECT/CT vs PET Imaging in Subjects With Liver Metastases.
Estimation of the concordance of Tc 99m localization in liver metastases from colorectal carcinoma using SPECT/CT imaging and abdominal FDG (PET)/CT imaging per subject.
- Trial name
- NCT03029988
- Testing
- Tilmanocept (Technetium Tc 99m tilmanocept Injection), SPECT/CT Imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Navidea Biopharmaceuticals
Breast Neoplasms, Liver Neoplasms
A Multi-mode Thermophysical Immunotherapy Study for Breast Cancer Liver Metastases
This is a single-center, parallel-controlled clinical study designed to evaluate the safety, efficacy and impact on systemic anti-tumor immunity of a multi-mode integrated ablation system for the treatment of breast cancer liver…
- Conditions
- Breast Neoplasms, Liver Neoplasms, Metastasis
- Trial name
- NCT06567353
- Testing
- Multi-mode tumor treatment system, Radiofrequency ablation therapeutic apparatus
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Colorectal Cancer, Steatohepatitis
A Randomized, Placebo-controlled, Double-blind Phase II Study Evaluating if Glucophage Can Avoid Liver Injury Due to Chemotherapy Associated Steatosis
This multicenter randomized, placebo-controlled phase II study will enroll 132 first-line palliative treated subjects with metastatic KRAS wild type CRC.
- Trial name
- G-LUCAS (NCT01523639)
- Where
- 7 sites in Austria
- Volunteers
- 8 people
- Sponsor
- Austrian Breast & Colorectal Cancer Study Group
Colon Cancer
Randomized Phase II Adjuvant Chemotherapy ± FANG™ in Colorectal Carcinoma With Liver Metastases
Preliminary studies with a variety of vaccines suggest target accessibility (potential immunogenicity) in a variety of solid tumors to immune directed approaches.
- Trial name
- FANG-CLM (NCT01505166)
- Testing
- Vigil™ Vaccine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Gradalis, Inc.
Colo-rectal Cancer, Liver Metastases
Radiogenomic Profiling of Dendritic Cells and Macrophages to Predict Recurrence in Colorectal Liver Metastasis
The RaP-DMac-LiMe study (Radiogenomic Profiling of Dendritic Cells and Macrophages to Predict Recurrence in Colorectal Liver Metastasis) is a monocentric, non-profit observational study promoted by Fondazione Policlinico…
- Conditions
- Colo-rectal Cancer, Liver Metastases, Colon Cancer
- Trial name
- RaP-DMac-LiMe (NCT07744139)
- Testing
- Radiogenomic and Immune Profiling, Prospective Radiogenomic and ctDNA Profiling
- Volunteers
- 210 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
CRC (Colorectal Cancer)
Efficacy and Safety of Retlirafusp Alfa Plus Bevacizumab and Chemotherapy With or Without Short-Course Radiotherapy in Patients With CRCLM
Efficacy and safety of retlirafusp alfa combined with bevacizumab and chemotherapy with or without short-course radiotherapy in conversion therapy for advanced colorectal cancer liver metastases: an exploratory study.
- Trial name
- NCT07728019
- Testing
- SCRT, Retlirafusp alfa Injection, Bevacizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Colorectal Cancer, Hepatic Metastases
Targeted Delivery of Chemotherapy With Ultrasound and Microbublles
The oscillations of ultrasound (US) contrast agent microbubbles under their activation by US waves engender a modulation of the permeability of biological barriers amplifying hence the extravasation of drugs and/or fluorescent…
- Trial name
- SONCHIMIO (NCT03458975)
- Testing
- MRI, Perfusion CT scan, Contrast enhanced ultrasound
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Tours
Hepatocellular Carcinoma
Efficacy and Safety of T+A+RAD in HCC
This is An Open-label, Single-arm Exploratory Study to determine the efficacy and safety of Multifocal Stereotactic Radiotherapy Combined with Atezolizumab and Bevacizumab in the Treatment of Metastatic Hepatocellular Carcinoma
- Trial name
- NCT05396937
- Testing
- Multifocal Stereotactic Radiotherapy, Atezolizumab Injection [Tecentriq], Bevacizumab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Fudan University
Neuroendocrine Tumors
Pasireotide, Everolimus and Selective Internal Radioembolization Therapy for Unresectable Hepatic Metastases
The purpose of this study is to see the safety and activity of using pasireotide, everolimus and radioembolization (Selective Internal Radioembolization Therapy-SIRT) in the treatment of neuroendocrine tumors (carcinoid) that has…
- Trial name
- NCT01469572
- Testing
- Pasireotide, Sir-sphere Radioembolization, Everolimus
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Emory University
Neuroendocrine Tumors
Holmium-166-radioembolization in NET After Lutetium-177-dotatate; an Efficacy Study
Patients with gastroenteropancreatic neuroendocrine tumours (NET) often die from intrahepatic disease or are excluded from liver-directed treatment because of extrahepatic disease.
- Trial name
- HEPAR_Plus (NCT02067988)
- Testing
- Holmium-166 microspheres hepatic radioembolization.
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- UMC Utrecht
Colorectal Cancer Metastatic
Assessing How Normal Variations in CT Scanning Affects Its Interpretation
The purpose of the study is to see how measurements of tumor differences vary with slight changes in CT scan parameters. Reproducible radiomic features can be extracted for abdominal tumors, and specifically colorectal liver…
- Trial name
- NCT03038568
- Testing
- CT scan
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer Liver Metastasis
Dose Escalation and Dose Expansion Phase I Study to Assess the Safety and Clinical Activity of Multiple Doses of NKR-2 Administered Concurrently With FOLFOX in Colorectal Cancer With Potentially Resectable Liver Metastases
SHRINK (Standard cHemotherapy Regimen and Immunotherapy with NKR-2) is an open-label Phase I study to assess the safety and clinical activity of multiple administrations of autologous NKR-2 cells administered concurrently with a…
- Trial name
- SHRINK (NCT03310008)
- Testing
- NKR-2 cells
- Where
- 4 sites in Belgium
- Volunteers
- 36 people
- Sponsor
- Celyad Oncology SA
Colorectal Cancer, Metastatic Cancer
Surgery With or Without Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and combining chemotherapy with surgery may kill more tumor cells.
- Trial name
- NCT00006479
- Testing
- FOLFOX regimen, fluorouracil, leucovorin calcium
- Where
- 111 sites in Australia, Austria and 11 more
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Liver Metastasis Colon Cancer
LT for Unresectable Colorectal Liver Metastasis
Unlike hepatocellular carcinoma, liver transplantation in patients with liver metastasis from colorectal cancer is limited in only few centers.
- Trial name
- NCT04874259
- Testing
- Living donor liver transplantation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Liver Cancer
Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients
This is a pilot study that uses a standard of care technique, Stereotactic Body Radiation Therapy (SBRT), in combination with Dynamic Contrast Enhanced Computed Tomography (DCE-CT) to determine if perfusion changes from SBRT of…
- Trial name
- NCT03891654
- Testing
- Dynamic Contrast Enhanced Computed Tomography
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Colorectal Cancer, Liver Metastases
Impact of Positron Emission Tomography Imaging Prior to Liver Resection for Colorectal Adenocarcinoma Metastases
The purpose of this trial is to improve the management of patients with potentially surgically curable colorectal cancer liver metastases.
- Trial name
- PETCAM (NCT00265356)
- Testing
- PET diagnostic imaging
- Where
- 9 sites in Canada
- Volunteers
- 404 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Colorectal Neoplasms
Anti-OX40 Antibody (MEDI6469) in Patients With Metastatic Colorectal Cancer
This study will test the ability of an immune modulator, anti-OX40 (MEDI6469) to alter the immune cell environment within colorectal cancer metastases. The drug will be administered to patients before surgical treatment.
- Trial name
- NCT02559024
- Testing
- MEDI6469
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Providence Health & Services
Colorectal Cancer, Liver Metastases
Synergism of Immunomodulation and Tumor Ablation
This is a single-arm, open-label, multi-center early phase II study. This proof of concept study will investigate whether the combined use of local tumor ablation/radiation plus immunomodulating drugs may induce a significant…
- Trial name
- ILOC (NCT03101475)
- Testing
- Durvalumab (MEDI4736), Tremelimumab, Sterotactic body radiation therapy (SBRT)
- Where
- 10 sites in Austria, France and 4 more
- Volunteers
- 22 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
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