Clinical trials: Metastatic Malignant Neoplasm to Brain
Melanoma
[18F]Dabrafenib Molecular Imaging in Melanoma Brain Metastasis
In this feasibility study, [18F]dabrafenib will be used as radioactive tracer. All patients in this study are diagnosed with advanced melanoma with evidence of brain metastases and are eligible for treatment with dabrafenib, a…
- Trial name
- NCT02700763
- Testing
- [18F]dabrafenib molecular imaging
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- University Medical Center Groningen
Breast Cancer, Brain Metastases
FSRT in Breast Cancer Patients With Brain Metastases
Brain metastasis accounted for 10-15% of all breast cancer patients and even higher in patients with triple negative and HER2 overexpressed subtype.
- Trial name
- NCT04061408
- Testing
- Fractionated stereotactic radiotherapy(FSRT)
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Fudan University
Brain Metastases
Hippocampus-sparing WBRT and Simultaneous Integrated Boost for Multiple Brain Metastases From NSCLC
This study evaluates hippocampus-sparing whole-brain radiotherapy with simultaneous integrated boost for patients with multiple brain metastases from non-small cell lung cancer.
- Trial name
- KROG17-06 (NCT03366376)
- Testing
- WBRT with hippocampus-sparing and SIB
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Metastases, Neoplasm
Radiomics for Prediction of Long Term Survival and Local Failure After Stereotactic Radiotherapy for Brain Metastases
Published prognostic scores have limitations in prediction of long term survival after stereotactic radiotherapy for brain metastases. Moreover, no validated tools are available for prediction of local failure.
- Trial name
- NCT02265549
- Where
- Netherlands
- Volunteers
- 155 people
- Sponsor
- Maastricht Radiation Oncology
Neuroectodermal Tumor, Brain Metastases
Valproate and Etoposide for Patients With Neuronal Tumors and Brain Metastases
Primary Objective: Determine the interindividual range and median of individual maximum tolerated doses of valproic acid administered as one time evening dose in conjunction with a dose oral etoposide (50 mg/m2/day for children…
- Conditions
- Neuroectodermal Tumor, Brain Metastases, Advanced Cancer
- Trial name
- NCT00513162
- Testing
- Valproate, Etoposide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Malignant Neoplasm to the Adult Brain
Sector Irradiation Versus Whole Brain Irradiation for Brain Metastasis
Microneurosurgical resection of intracerebral metastases leads to prolonged survival and relief of symptoms in selected patients.
- Trial name
- NCT01667640
- Testing
- sector irradiation, whole brain irradiation
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University Innsbruck
Lung Cancer, Breast Cancer
Neural Stem Cell Preserving Brain Radiation Therapy & Stereotactic Radiosurgery in Patients With 1-6 Brain Metastases
For patients with 1-6 intraparenchymal brain metastases from various primary histologies (except for melanoma), stereotactic radiosurgery (administered upfront or concurrently) or complete surgical resection with neural stem cell…
- Conditions
- Lung Cancer, Breast Cancer, Prostate Cancer
- Trial name
- NCT00581113
- Testing
- Radiotherapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Virginia Commonwealth University
Carcinoma, Non-Small-Cell Lung
Impact of a Radiologic and Immunologic Signature on Cerebral Efficacy of Treatments in Lung Cancers With Brain Metastasis
Non-small cell lung cancer frequently spreads to the brain, and brain metastases are associated with poor prognosis and limited treatment response.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Brain Neoplasms, Neoplasm Metastasis
- Trial name
- SIREC-Poumon (NCT07904013)
- Testing
- Radiomic analysis; Bulk RNA sequencing
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Bordeaux
Central Nervous System Neoplasms
Comparison of Contrast Agents for MRI Perfusion Analysis in Brain Tumor Patients
This study will compare the use of two contrast agents to analyze blood flow characteristics of brain tumors.
- Trial name
- NCT02095353
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Nebraska
Breast Cancer, Brain Metastases From Breast Cancer
Evaluation of Trop-2 ADC in Breast Cancer Patients With Brain Metastases: A Real-World Study
The goal of this real-world study (RWS) is to evaluate the effectiveness of Trop-2 ADC (sacituzumab govitecan) in treating breast cancer patients with brain metastases, and to understand the safety profile of this drug in real…
- Conditions
- Breast Cancer, Brain Metastases From Breast Cancer, Trop2
- Trial name
- NCT07251868
- Testing
- Sacituzumab Govitecan (SG)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Cancer Hospital & Institute
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain
RATIONALE: Donepezil may decrease the side effects caused by radiation therapy to the brain. PURPOSE: This clinical trial is studying how well donepezil works in treating young patients with primary brain tumors previously…
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Long-term Effects Secondary to Cancer Therapy in Children, Neurotoxicity
- Trial name
- NCT00452868
- Testing
- Donepezil
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Metastatic Breast Cancer, Brain Metastases
Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate
Subjects are asked to take part in a clinical research study that tests Eribulin, a new drug. Eribulin is an investigational (experimental) anti-cancer agent that has not been approved by the Food and Drug Administration (FDA)…
- Trial name
- NCT02581839
- Testing
- Eribulin Mesylate, MRI, Pre-Medication: Zofran
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Case Comprehensive Cancer Center
Metastatic Non Small Cell Lung Cancer
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastases
20-40% of patients with NSCLC will develop brain metastases at some point during their course of disease. Osimertinib has demonstrated intracranial activity in EFGR mutated NSCLC with leptomeningeal disease in the phase 1 BLOOM…
- Trial name
- OUTRUN (NCT03497767)
- Testing
- Osimertinib, Stereotactic Radiosurgery (SRS)
- Where
- 13 sites in Australia, Singapore
- Volunteers
- 40 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Prostatic Neoplasms, Esophageal Neoplasms
Tumor Hypoxia With HX4 PET in Several Diseases
Regulation of tissue oxygen homeostasis is critical for cell function, proliferation and survival. Evidence for this continues to accumulate along with our understanding of the complex oxygen-sensing pathways present within…
- Conditions
- Prostatic Neoplasms, Esophageal Neoplasms, Neoplasm Metastases, Brain, Rectal Neoplasms
- Trial name
- HX4 SD (NCT02584400)
- Testing
- Injection with the hypoxia tracer [18F]HX4,
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Maastricht Radiation Oncology
Non Small Cell Lung Cancer, Brain Metastases
Study of Cadonilimab Combined With Bevacizumab and Chemotherapy for Advanced Nonsquamous Non-small Cell Lung Cancer Patients With Untreated Brain Metastases
The purpose of this study was to investigate the efficacy and safety of Cadonilimab combined with bevacizumab and chemotherapy for advanced non-squamous NSCLC with untreated brain metastases.
- Trial name
- CBC (NCT05812534)
- Testing
- Cadonilimab
- Volunteers
- 36 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Breast Cancer, Breast Carcinoma
Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain Metastases
Background: Breast cancer is the most common cancer among women. It can often spread to the liver, lungs, bones, or brain. Breast cancer that spreads to the brain is often fatal.
- Conditions
- Breast Cancer, Breast Carcinoma, Cancer of the Breast, Malignant Neoplasm of Breast
- Trial name
- NCT07619534
- Testing
- Arm 1
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling
The purpose of this research is to look at the safety and effectiveness of a HER2-targeted therapy neratinib when given with capecitabine, a chemotherapy, for breast cancer patients with brain metastases whose tumors were…
- Trial name
- NCT04965064
- Testing
- Capecitabine and Neratinib.
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Rochester
Melanoma
PD-L1 PET Imaging in Melanoma Patients
This is a feasibility study for the use of [18F]PD-L1 as a PET tracer that will be conducted in a single center. The study consists of two phases.
- Trial name
- NCT03520634
- Testing
- PD-L1 PET imaging
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Brain Metastases
Apatinib Plus Radiotherapy for Patients With Brain Metastases From Non-small-cell Lung Cancer
To observe the effectiveness and safety of apatinib combined with radiotherapy for brain metastasis from non-small cell lung cancer patients
- Trial name
- NCT03356600
- Testing
- Apatinib plus radiotherapy
- Volunteers
- 44 people
- Sponsor
- Shanxi Province Cancer Hospital
Breast Cancer, Estrogen Receptor-Positive
Validity of Brain Metastasis Risk Predictive Model in Hormone Positive Breast Cancer Patients
This study aims to validate a prediction model of brain metastasis risk for females with HR+ breast cancer by using variables collected at diagnosis.
- Trial name
- NCT06729099
- Volunteers
- 128 people
- Sponsor
- Assiut University