Clinical trials: Metformin, Prediabetes
Pre Diabetes, Type 2 Diabetes Mellitus
Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes
Prediabetes is a common condition in overweight individuals affecting approximately 35% of American adults and 30% of Australian adults.
- Trial name
- PREDICT (NCT03558867)
- Testing
- Metformin + Healthy diet, Metformin + Personalized diet
- Where
- Australia
- Volunteers
- 138 people
- Sponsor
- Garvan Institute of Medical Research
Prediabetes
Mitochondrial-related Platelet Transcript Expression Levels in Pre-diabetic Subjects Randomized to Metformin or Placebo
Diabetes mellitus (DM) imposes an approximate 2-fold increased risk of atherothrombosis. Patients with type 2 DM have a 2- to 4-fold increase in the risk of coronary artery disease (CAD) and atherothrombotic complications.
- Trial name
- MAP-2 (NCT02682121)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Utah
Prediabetic State, Insulin Resistance
Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes
Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this trial is to evaluate the effect of empagliflozin + linagliptin + metformin + lifestyle on…
- Trial name
- 4T (NCT04131582)
- Testing
- Linagliptin + metformin and Empagliflozin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Universidad de Guanajuato
Prostate Cancer
Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients
Metformin is used widely in the treatment of type 2 diabetes. It has off-label indications for use in the prevention of diabetes and in hyperinsulinar obesity.
- Trial name
- PragMet (NCT05515978)
- Testing
- Metformin, Lifestyle Modification
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
PreDiabetes, HIV-1-infection
Metformin and Systemic Inflammation in HIV
The purposes of this study are to find out if: metformin can be combined with anti-HIV drugs to reduce systemic inflammation measured by the determination of cytokines and other series of serum markers.
- Trial name
- Metfo (NCT03774108)
- Testing
- Metformin Hydrochloride 850 MG
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital Civil de Guadalajara
Coronary Artery Disease, PreDiabetes
Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes
The purpose of the study is to compare the anti-atherosclerotic efficacy of oral treatment with a GLP-1 analogue (semaglutide) or an SGLT-2 (so-called "flozin") inhibitor (dapagliflozin) versus routine treatment (metformin) in…
- Trial name
- CASCADES (NCT07254572)
- Testing
- Semaglutide 14 MG [Rybelsus], Dapagliflozin (Forxiga), Metformin
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
PreDiabetes
Efficacy of Metformin in Preventing Diabetes in China
A multicentred, randomized, open study to evaluate the efficacy of metformin in preventing Diabetes.
- Trial name
- ChinaDPP (NCT03441750)
- Testing
- metformin, Standard lifestyle intervention
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- Chinese Association of Geriatric Research
Impaired Glucose Tolerance, Type2 Diabetes
Influence of Preprandial Metformin Administration on Carbohydrate Absorption
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
- Trial name
- METTIME (NCT04018105)
- Testing
- Oral glucose tolerance test (OGTT) with or without metformin
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
PreDiabetes, Obesity, Morbid
Effectiveness of Dapagliflozin for Weight Loss
Mexico has one of the highest prevalence of obesity, reported on 32.4 percent of people over 20 years old, with a prevalence of obesity class III of 1.8 percent on males and 4.1 percent on females.
- Conditions
- PreDiabetes, Obesity, Morbid, Diabetes Mellitus, Type 2
- Trial name
- NCT03968224
- Testing
- Dapagliflozin/Metformin, Metformin
- Where
- Mexico
- Volunteers
- 160 people
- Sponsor
- Centro Medico Nacional Siglo XXI IMSS
Impaired Glucose Tolerance
The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes
The purpose of this study is to compare the effects of exenatide versus metformin on vascular health with chronic (3-month) therapy and during a 2-hour period following a meal in patients with pre-diabetes.
- Trial name
- NCT00546728
- Testing
- Exenatide, Metformin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- St. Paul Heart Clinic
PreDiabetes, Impaired Glucose Tolerance
High FODMAP Diet With Metformin in preDM
This is a prospective, double blinded, randomised cross over feeding trial examine high or low FODMAP diet in combination with metformin on postprandial glucose responses and gastrointestinal tolerability and gut microbiota…
- Trial name
- NCT05628584
- Testing
- High FODMAP diet with metformin, Low FODMAP diet with metformin
- Where
- Hong Kong
- Volunteers
- 26 people
- Sponsor
- Elaine Chow
Pre-diabetes
Therapeutic Intervention of Eriomin Associated with Metformin in the Control of Hyperglycemia in Pre-Diabetic Patients
Citrus bioflavonoids, such as eriocitrin, hesperidin and naringin, have been shown improved hyperglycemia, insulin resistance and systemic inflammation, related to the development of type 2 diabetes.
- Trial name
- Eriomin+Met (NCT06005142)
- Testing
- Eriomin, Washout
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Thais Cesar
Pre Diabetic, Pre Diabetes
Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults
This study is being done to compare the effect of regular exercise and metformin in people who have prediabetes. It is a community-based, open-label, randomized trial in which eligible participants will be divided into two…
- Trial name
- NCT07061496
- Testing
- Moderately intense exercise, MetFORMIN 500 Mg Oral Tablet
- Where
- Pakistan
- Volunteers
- 226 people
- Sponsor
- Asad Ullah Jan
Diabetes, Pre-diabetes
Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)
The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α…
- Conditions
- Diabetes, Pre-diabetes, Obesity
- Trial name
- NCT01876992
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to determine the safety and effectiveness of adding alogliptin, once daily (QD), compared to glipizide with metformin in diabetic patients.
- Trial name
- ENDURE (NCT00856284)
- Testing
- Alogliptin, Metformin, Glipizide
- Where
- 261 sites in United States, Argentina and 30 more
- Volunteers
- 2,639 people
- Sponsor
- Takeda
Diabetes Mellitus, Type 2, Prediabetic State
PRuDENTE; Diabetes Prevention Via Exercise, Nutrition and Treatment
The PRuDENTE study proposes to assess if metformin therapy a viable, efficient and cost-effective intervention to decrease the incidence of type 2 diabetes (DMT2) in adult subjects with obesity and pre-diabetes in Mexico City.
- Trial name
- PRuDENTE (NCT03194009)
- Testing
- Metformin, Lifestyle intervention
- Where
- Mexico
- Volunteers
- 3,060 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Physical Activity
Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program.
- Trial name
- NCT02552355
- Testing
- Metformin, Carbohydrate Beverage, Protein Beverage
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Metabolic Syndrome (MetS), Glucose Intolerance
Metformin Withdrawal In Metabolic Syndrome
The goal of this clinical trial is to investigate how a short-term interruption of metformin treatment affects insulin sensitivity, glucose control, and metabolic flexibility in adults with metabolic syndrome who are taking…
- Trial name
- METMS (NCT07659444)
- Testing
- Temporary Metformin Withdrawal
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- University of Castilla-La Mancha
Insulin Resistance, Prediabetic State
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.
This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function.
- Trial name
- NCT01956929
- Testing
- Metformin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prediabetes, Type 2 Diabetes
Beta Cell Restoration Through Fat Mitigation
Weight loss achieved through gastric banding will be superior to treatment with metformin in preserving or restoring pancreatic beta cell function in people with prediabetes or mild type 2 diabetes.
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity
- Trial name
- BetaFat (NCT01763346)
- Testing
- Metformin, gastric banding
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Southern California