Clinical trials: Metformin, Prediabetes, open to volunteers
Prediabetic State, Atherosclerosis
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
- Conditions
- Prediabetic State, Atherosclerosis, Metformin
- Trial name
- VA-IMPACT (NCT02915198)
- Testing
- Metformin XR
- Where
- 40 sites in United States
- Volunteers
- 7,410 people
- Sponsor
- VA Office of Research and Development
HIV, Pre-diabetes
META Trial - a Mixed Methods Process Evaluation
The aim of this study is to conduct a mixed methods process evaluation of the META trial. Semi-structured interviews, focus groups, and brief questionnaires will be conducted with a purposive sample of participants (patients and…
- Trial name
- META (NCT06743698)
- Volunteers
- 60 people
- Sponsor
- University College Dublin
Males, Females
Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes
This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes.
- Conditions
- Males, Females, Sedentary, Metformin
- Trial name
- NO3-PreDM (NCT07131384)
- Testing
- Dietary Supplement: Inorganic Nitrate (Beetroot juice)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Coronary Artery Disease, PreDiabetes
Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes
The purpose of the study is to compare the anti-atherosclerotic efficacy of oral treatment with a GLP-1 analogue (semaglutide) or an SGLT-2 (so-called "flozin") inhibitor (dapagliflozin) versus routine treatment (metformin) in…
- Trial name
- CASCADES (NCT07254572)
- Testing
- Semaglutide 14 MG [Rybelsus], Dapagliflozin (Forxiga), Metformin
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Metformin, Prediabetes
Effect of Metformin on Healthy Live Birth in Women With Prediabetes
To evaluate the efficacy and safety of metformin pretreatment on reproductive outcomes in infertile women with prediabetes.
- Conditions
- Metformin, Prediabetes, In-Vitro Fertilization
- Trial name
- MELT-PreDM (NCT06064669)
- Testing
- Metformin pretreatment before ovarian stimulation, Metformin pretreatment before endometrial preparation for frozen embryo transfer
- Where
- China
- Volunteers
- 988 people, healthy volunteers welcome
- Sponsor
- Shandong University