Clinical trials: Metformin
Cervical Cancer, Radiotherapy
Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer
This is a prospective, single-center, phase II, randomized, window-of-opportunity trial initiated by researchers. The research hypothesis is that metformin can improve the level of hypoxia in locally advanced cervical cancer and…
- Conditions
- Cervical Cancer, Radiotherapy, Metformin, Hypoxia
- Trial name
- NCT06353061
- Testing
- Metformin, Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Peking Union Medical College Hospital
Polycystic Ovary Syndrome, Chiglitazar
Chiglitazar/Metformin in Non-obese Women With PCOS
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorders in women of reproductive age, and its prevalence rate is from 9% (NIH criteria) to 18% (Rotterdamcriteria).
- Conditions
- Polycystic Ovary Syndrome, Chiglitazar, Metformin
- Trial name
- NCT06125587
- Testing
- Chiglitazar, Metformin
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Shengjing Hospital
Polycystic Ovary Syndrome, Metformin
Study of Acupuncture to Control Weight and Improve Pregnancy Rates in Overweight/Obese PCOS Patients
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and is characterized by ovulatory dysfunction, increased androgens, and polycystic ovaries.
- Conditions
- Polycystic Ovary Syndrome, Metformin, Acupuncture
- Trial name
- NCT06717087
- Testing
- Acupuncture+lifestyle intervention, Metformin+lifestyle intervention
- Where
- China
- Volunteers
- 92 people
- Sponsor
- RenJi Hospital
Metformin, CA Endometrium
Comparison of the Effectiveness Metformin for Deceasing Proliferative Marker in Endometrial Cancer Cells
Comparison of the effectiveness metformin versus placebo for deceasing proliferative marker Ki-67 expression in endometrial tumours when given for 4 weeks before hysterectomy in endometrial cancer cells.
- Trial name
- NCT03618472
- Testing
- Metformin Hydrochloride 850 MG
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Methylglyoxal, PreDiabetes
Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals
The aim of this study is to compare the effects of exercise, standard lifestyle changes and metformin on MGO in prediabetic individuals.
- Conditions
- Methylglyoxal, PreDiabetes, Exercise, Metformin
- Trial name
- NCT06603480
- Testing
- Exercise, Metformin
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Type 2 Diabetes Mellitus (T2DM), Cost-effectiveness, Sulfonylureas, DPP4 Inhibitors, Metformin
Comparative Analysis of Cost-effectiveness Between Sulfonylureas and DPP4 Inhibitors in Combination With Metformin in Treatment of Type 2 Diabetic Patients : A Retrospective, Observational Study.
The aim of this study is to compare the cost effectiveness of Sulfonylureas and DPP4-inhibitors in combination with Metformin among type2 diabetic patients diagnosed for 2-5 years.
- Trial name
- NCT06570980
- Testing
- sulfonylurease with metformin, DPP4 inhibitors with Metformin
- Where
- Bangladesh
- Volunteers
- 200 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Metformin, Prediabetes
Effect of Metformin on Healthy Live Birth in Women With Prediabetes
To evaluate the efficacy and safety of metformin pretreatment on reproductive outcomes in infertile women with prediabetes.
- Conditions
- Metformin, Prediabetes, In-Vitro Fertilization
- Trial name
- MELT-PreDM (NCT06064669)
- Testing
- Metformin pretreatment before ovarian stimulation, Metformin pretreatment before endometrial preparation for frozen embryo transfer
- Where
- China
- Volunteers
- 988 people, healthy volunteers welcome
- Sponsor
- Shandong University
Polycystic Ovary Syndrome, Metformin
PCOS Immune Function Predicts Metformin Efficacy
In this study, the investigators will include PCOS patients who meet the trial criteria, introduce participants to the content of this study, and invite participants to participate.
- Conditions
- Polycystic Ovary Syndrome, Metformin, Immune Function
- Trial name
- NCT06325956
- Testing
- Metformin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Metformin for Obese Pregnant Women
Maternal and Fetal Outcome With Metformin Therapy for Obese Pregnant Women .
To evaluate the role of metformin in pregnant women with obesity (BMI above 30) , on maternal and infant outcome.
- Trial name
- NCT05554679
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 178 people
- Sponsor
- Assiut University
Knee Osteoarthritis, Metformin
Effect of Metformin as Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients.
The goal of this randomized, double blind, placebo-controlled clinical trial is to learn about, the effect of metformin compared with placebo-controlled group on disease activity and interleukin-6 level in patients with knee…
- Trial name
- NCT06126029
- Testing
- Metformin 500 Mg extended release Oral Tablet
- Where
- Bangladesh
- Volunteers
- 68 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Efficacy and Safety of Chiglitazar Sodium in the Treatment of T2DM Patients, Metformin Combined With Insulin Glargine in the Treatment of Type 2 Diabetes Patients Who Still Have Poor Hypoglycemic Effect
Efficacy and Safety of Chiglitazar Added to Glargine in Patients With Type 2 Diabetes
The goal of this clinical trial is to evaluate the Efficacy and Safety of Chiglitazar Added to Patients with type 2 diabetes who do not respond well to metformin combined with insulin glargine.
- Conditions
- Efficacy and Safety of Chiglitazar Sodium in the Treatment of T2DM Patients, Metformin Combined With Insulin Glargine in the Treatment of Type 2 Diabetes Patients Who Still Have Poor Hypoglycemic Effect, 128 Patients Were Randomly Assigned 1:1, Metformin and Insulin Glargine Combined With Chiglitazar Sodium Tablets 48mg/ Day Group
- Trial name
- NCT06007014
- Testing
- Chiglitazar sodium
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Yanbing Li
Dengue, Viral Infection
Metformin in Dengue With Obesity
This study aims to investigate the effect of metformin as host-directed therapy in obese/overweight patients with dengue Primary Objective To evaluate the safety and tolerability of metformin in obese/overweight young adults and…
- Conditions
- Dengue, Viral Infection, Metformin, Anti-inflammatory Agents
- Trial name
- MeDO (NCT04377451)
- Testing
- Metformin
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Metabolic Syndrome, Protection Against, Exercise Training
Interactions of Medicine and Exercise With Meal Timing
To analyze the effects of altering the time of ingestion of participants' habitual medication (i.e., metformin, statins, ARAII/IACE) and meals around the time of exercise training (exercise fasted or fed) on the improvement of…
- Conditions
- Metabolic Syndrome, Protection Against, Exercise Training, Metformin, Statins
- Trial name
- MMET (NCT04477590)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- University of Castilla-La Mancha
Diabetes Mellitus, Type 2 AND Metformin
The Efficacy of Metformin Produced by Pars Mino Co in Comparison With Canadian Apotex Co.
Background: Metformin is usually using for glycemic control in type 2 diabetes mellitus. Different pharmaceutical types of metformin are available.
- Trial name
- NCT01228240
- Testing
- Metformin
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Zanjan University of Medical Sciences
Diabetes, Bariatric Surgery
Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard Care
This study is a randomized trial that evaluates the effect of metformin addition or not to standard care on the duration of diabetes remission after bariatric surgery.
- Conditions
- Diabetes, Bariatric Surgery, Metformin
- Trial name
- DiabOUT (NCT04581447)
- Testing
- Metformin, Standard Care, Standardized meal
- Where
- 16 sites in France
- Volunteers
- 126 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metformin, Obesity, Abdominal
Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus
The purpose of this study is to analyze the effects of GLP-1RA on blood glucose, body weight, glucose and lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus.
- Conditions
- Metformin, Obesity, Abdominal, Diabetes Mellitus, Type 2, Abdominal Fat
- Trial name
- NCT05779644
- Testing
- Liraglutide, Semaglutide, Metformin
- Where
- China
- Volunteers
- 300 people
- Sponsor
- RenJi Hospital
Alport Syndrome, Metformin
Treatment With Metformin in Chinese Children With Alport Syndrome
This single-center, prospective, double-blind randomized placebo-controlled trial will evaluate the efficacy and safety of metformin in Chinese children with Alport syndrome who have received (and continue to receive)) ACEi/ARB.
- Trial name
- NCT05655728
- Testing
- Metformin
- Volunteers
- 78 people
- Sponsor
- Peking University First Hospital
Post-transplant Diabetes Mellitus, New Onset Diabetes After Transplant
The POWERED Study: Prophylaxis With Metformin to Prevent PTDM
PrOphylaxis With mEtformin to pREvent PTDM: a single site, placebo controlled, double blind randomised clinical trial evaluating the effectiveness of metformin to prevent post-transplant diabetes in a cohort of patients…
- Conditions
- Post-transplant Diabetes Mellitus, New Onset Diabetes After Transplant, New Onset Diabetes After Transplantation, Kidney Transplant; Complications
- Trial name
- POWERED (NCT05240274)
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Barts & The London NHS Trust
T2DM (Type 2 Diabetes Mellitus), Metformin
Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD)
This multicenter, randomized, open-label, controlled study will assess the efficacy of the SGLT2 inhibitor tofogliflozin on Urine Albumin-to-Creatinine Ratio (UACR) compared to metformin in patients with type 2 diabetes with…
- Conditions
- T2DM (Type 2 Diabetes Mellitus), Metformin, SGLT2-Inhibitors
- Trial name
- TRUTH-DKD (NCT05469659)
- Testing
- Tofogliflozin, Metformin
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- Shinshu University
Polycystic Ovary Syndrome, Metformin
Effects of Metformin on Metabolic and Reproductive Outcomes in Chinese PCOS Patients
Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by reproductive and metabolic abnormalities, which is a crucial cause of female infertility and an essential risk factor for type 2 diabetes.
- Trial name
- NCT05463627
- Testing
- Metformin
- Where
- China
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital