Clinical trials: Methadone, open to volunteers
Pain Management
Methadone Versus Standard of Care for Pain Control in Minimally Invasive Lung Resection Surgery
This study is being done to find out if methadone is more effective in controlling pain in patients presenting for minimally invasive lung resection surgery compared to the standard of care.
- Trial name
- NCT07914751
- Testing
- Methadone, Standard of Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Wake Forest University Health Sciences
Opioid Use Disorder, Substance-Related Disorders
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
The goal of this observational study is to learn about the long term effects of prenatal opioid exposure. The main objectives are: Long term goal: to improve the safety and efficacy of maternal Opioid Use Disorder (OUD) and…
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Pregnancy Related, Narcotic-Related Disorders
- Trial name
- NCT06415994
- Testing
- Buprenorphine or Methadone Treatment, Fetal and Placental MRI, Child Developmental Assessment
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid Use Disorder, Tobacco Use Disorder
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder
This pilot study will evaluate the use of deep transcranial magnetic stimulation (Deep TMS) to help adults with opioid use disorder (OUD) who are receiving medications for opioid use disorder (MOUD) such as buprenorphine or…
- Trial name
- NCT07770555
- Testing
- Deep TMS System With H4 Coil
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Payel Roy
Quality of Recovery Scores
Methadone and Quality of Postoperative Recovery
Patients undergoing cardiac surgery often experience moderate to severe pain in the early postoperative period. A number of methods have been used to help control pain after surgery; however, each of these techniques adds…
- Trial name
- NCT03168958
- Testing
- Methadone, Saline
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Endeavor Health
Healthy
A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)
This study is designed to determine the effect of ulonivirine (MK-8507) on methadone in the body. Participants will take methadone alone and then methadone with ulonivirine to see if ulonivirine changes how the body processes…
- Trial name
- NCT07595263
- Testing
- Ulonivirine, Methadone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Spine Surgery
The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.
This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain…
- Trial name
- NCT07365800
- Testing
- Methadone-dexmedetomidine-ketamine combination
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- University of Missouri-Columbia
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Post Operative Pain
Methadone in TKA for Post-op Pain and Opioid Reduction
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total…
- Trial name
- NCT07226076
- Testing
- Methadone Hydrochloride
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder, Pain
Assessing Concentrations of Methadone and Its Metabolites
An observational proof of concept method comparison study. Comparing Liquid Chromatography -Mass Spectroscopy to a new Quantitative Lateral Flow Immunoassay with an Optical Reader.
- Trial name
- NCT06835582
- Testing
- Methadone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cari Health Inc.
Total Knee Arthroplasty
Methadone in the Management of Post-Operative Pain in Total Knee Replacement
The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks…
- Trial name
- NCT07485803
- Testing
- Methadone
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- AdventHealth
Opioid Use Disorder, Opioid Use Disorder, Moderate
TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization
The primary objective of this study is to evaluate the ability of TRTME to increase initiation of MOUD outpatient treatment and MOUD knowledge in hospitalized patients with OUD deemed to be good candidates for MOUD by the UCMC…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- TRTME (NCT07780097)
- Testing
- TRTME
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- T. John Winhusen, PhD
Analgesia, Cardiac Surgery
Precision Analgesia for Cardiac Surgery
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Trial name
- NCT05612399
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Kathirvel Subramaniam
Brain Injury, Brain Tumors
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery
Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of…
- Conditions
- Brain Injury, Brain Tumors, Craniotomy Surgery, Pain
- Trial name
- NCT06810336
- Testing
- Remifentanil, Methadone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Opioid Use Disorder, Chronic Pain
Divided or Single Exposure (DOSE) Study
This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.
- Conditions
- Opioid Use Disorder, Chronic Pain, Methadone
- Trial name
- NCT05459402
- Testing
- Methadone (100% dose), Methadone (50% dose)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Maryland, Baltimore
Opioid Use Disorder
tDCS to Decrease Opioid Relapse (UH3)
Investigators will measure behavioral and brain responses following transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) (anode on right DLPFC, cathode on the left DLPFC) delivered during…
- Trial name
- NCT06432465
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Butler Hospital
Postoperative Pain, Recovery
Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)
Postoperative pain control remains suboptimal for a large proportion of surgical patients and is frequently associated with slower recovery and higher reliance on opioids after surgery.
- Trial name
- MELODY (NCT07565870)
- Testing
- Intravenous Methadone, Short-acting Opioids Intraoperative analgesia
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Alexandre P. Joosten
Post Operative Pain, Total Hip Arthroplasty
Methadone in THA for Post-op Pain and Opioid Reduction
This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing…
- Trial name
- NCT07227064
- Testing
- Methadone
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder
PRoducing Outcome Measures for OTP Quality Improvement
This study tests ways to help opioid treatment programs (OTPs) keep patients in care. Staying on methadone or buprenorphine is linked to better outcomes, yet many people leave treatment early.
- Trial name
- PROMOTE-QI (NCT07214389)
- Testing
- Quality Measures (Audit and Feedback), Quality Improvement (QI) Toolkit, External QI Facilitation
- Where
- United States
- Volunteers
- 4,500 people
- Sponsor
- RTI International
Cocaine Use Disorder
Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment of cocaine addiction and the psychosocial treatment patients receive…
- Trial name
- NCT05529927
- Testing
- Sustained-release Dexamphetamine
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Parnassia Addiction Research Centre