Clinical trials: Methotrexate Toxicity, open to volunteers
Rheumatoid Arthritis (RA)
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate
The goal of this clinical trial is to evaluate the anti-rheumatic activity and the role of silymarin in attenuating methotrexate toxicity in patients with rheumatoid arthritis.
- Trial name
- NCT06724952
- Testing
- MTX S.C or IM and Silymarin 140 mg tab, MTX S.C or IM
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Primary Central Nervous System Lymphoma
Methotrexate Early Toxicity Monitoring
High-dose methotrexate (MTX) is the main componement of first line treatment in primary central nervous system lymphoma. Renal toxicity is the main dose limiting toxicity because of major MTX elimination by the kidneys.
- Trial name
- METoxiM (NCT07406230)
- Testing
- methotrexate plasmatic dosing
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille