Clinical trials: Methylation
One-carbon Metabolism in Healthy Individuals
Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA Formation
Periconceptional supplementation with folic acid - the synthetic form of the B-vitamin folate - reduces the occurrence of adverse pregnancy outcomes such as spina bifida.
- Trial name
- NCT01687127
- Testing
- Folic acid, 5-methyltetrahydrofolate, calcium salt
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Full Term Infants, Environmental Exposures
Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants
Metabolic diseases such as obesity and diabetes are modern day epidemics. Early life exposure to an adverse developmental environment, including environmental toxins, are linked to increased susceptibility to obesity, metabolic…
- Conditions
- Full Term Infants, Environmental Exposures, Adiposity
- Trial name
- NCT01815385
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Stunting, Development, Child
Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
The investigators will conduct a case-control study among under-two children in Lombok Timur, West Nusa Tenggara, Indonesia. The power required to detect changes in epigenetic markers may not be sufficient in the cohort study.
- Conditions
- Stunting, Development, Child, DNA Methylation, Epigenetics
- Trial name
- MINUTES (NCT05779904)
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Pneumonia
The Effect of Leukocyte Dna mEthylation and micRoBIOME Diversity on Host Defense Mechanisms During Community-acquired Pneumonia (ELDER-BIOME)
Community-acquired pneumonia (CAP) represents a major health care problem and mortality and morbidity associated with severe pneumonia remain considerable, despite state of the art care.
- Trial name
- ELDER-BIOME (NCT02928367)
- Testing
- rectal swab, nasopharyngeal swab, blood draw
- Where
- Netherlands
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Neoplasm, Pancreas Cancer
MSCAN: ctDNA Methylation as Prognostic and Theranostic Tool for Pancreatic Cancer
Developing a characteristic ctDNA methylation panel for pancreatic ductal adenocarcinoma and establishing an intelligent diagnostic and dynamic monitoring model based on ctDNA methylation.
- Trial name
- NCT07045571
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yingbin Liu, MD, PhD, FACS
Coronary Artery Disease, Acute Coronary Syndrome
DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial
Although epigenetics has been identified as one of the most relevant pathophysiological components in the development of cardiovascular diseases, there is still considerable difficulty in finding markers of epigenetic damage…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Atrial Fibrillation
- Trial name
- NCT04371809
- Testing
- DNA methylome
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
CIN2
Conservative Management of CIN2 Lesions and Biomarkers Evaluation
Prospective study including women aged 25-45 years, adherent to the cervical screening program of four different centers of the Veneto region, with a diagnosis of CIN2 lesion.
- Trial name
- NCT04687267
- Where
- 4 sites in Italy
- Volunteers
- 319 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Multiple Myeloma
Assessment of Early Detection and Prognosis Based on cfDNA Methylation in Multiple Myeloma
It is an observational, case-control study aimed at early-detection of multiple myeloma and constructing a prognostic model of multiple myeloma.
- Trial name
- NCT05693012
- Testing
- cfDNA methylation assessment
- Where
- China
- Volunteers
- 398 people
- Sponsor
- Qiu Lugui
Glioma, Glioblastoma (GBM)
STUPP Regimen With or Without Lenvatinib for Newly Diagnosed Glioblastoma With MGMT Promoter Methylation
To compare the efficacy and safety of Lenvatinib combined with the standard Stupp regimen versus the standard Stupp regimen alone in the treatment of newly diagnosed glioblastoma with MGMT promoter methylation positive.
- Conditions
- Glioma, Glioblastoma (GBM), MGMT-Methylated Glioblastoma
- Trial name
- NCT07754734
- Testing
- Lenvatinib, TMZ (Temozolomide), radiotherapy
- Volunteers
- 138 people
- Sponsor
- Dongguan People's Hospital
Gastric Carcinoma
DNA Methylation Biomarkers and Metastasis of Gastric Carcinoma
Gastric carcinoma (GC) is the second leading cause of cancer death throughout the world. In previous multi-center study, we have found that the prevalence of GDNF family receptor alpha 1(GFRA1), serum response factor (SRF), and…
- Trial name
- NCT02159339
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Cancer, Lung; Node
Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules
Lung cancer screening is based on low dose CT scan (LDCT), a highly sensitive but poorly specific tool. Complementary specific approaches are thus strongly needed, among which cell-free DNA (cfDNA) genotyping has been proven…
- Trial name
- KOBE (NCT05306912)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Healthy
Effect of a Multivitamin/Multimineral/Phytochemical Dietary Supplement on Indices of Human Health
This is a global transcriptomics and epigenetic pilot study designed to identify changes in gene expression and DNA methylation patterns following the consumption of an MVM/phytochemical supplement in a small group of healthy…
- Trial name
- NCT03146312
- Testing
- MVM/phytochemical supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- USANA Health Sciences
Obesity, Overfeeding
Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity
- Conditions
- Obesity, Overfeeding, Muscle Mass, Body Composition
- Trial name
- LIPOGAIN-2 (NCT02211612)
- Testing
- PUFA-group, SFA-group
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Obesity
Dietary Intervention and Assessment of Obesity-related Gene Methylation Levels in Overweight Women
The clinical study aimed to study the effect of an intervention with foods containing folate and hazelnut oil to assess whether this diet could modulate the methylation levels of two obesity-related genes, LEP and POMC, in…
- Trial name
- NCT04523532
- Testing
- Dietary folate and hazelnut oil
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Thamires Ribeiro Chaves
Colorectal Cancer
Circulating Tumor DNA Methylation Guiding Postoperative Adjuvant Chemotherapy in Stage III Colorectal Cancer
The goal of this randomized controlled trial is to investigate whether ctDNA methylation is a more precise indicator to guide postoperative adjuvant chemotherapy in stage Ill colorectal cancer.
- Trial name
- cmPAT (NCT06167967)
- Testing
- ctDNA methylation, standard treatment
- Where
- China
- Volunteers
- 990 people
- Sponsor
- Sir Run Run Shaw Hospital
Taurine, Aging, Biological
Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men
The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months.
- Conditions
- Taurine, Aging, Biological, Physical Activity, Metabolic Health
- Trial name
- TauAge (NCT06613542)
- Testing
- 4g of taurine daily
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Heart Rate, Heart Rate Variability
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
In this study, the pills formulated are being used to try to ameliorate the effect of air pollution on epigenetic changes, specifically DNA methylation, potentially linked with particulate matter air pollution inhalation and…
- Conditions
- Heart Rate, Heart Rate Variability, Inflammation
- Trial name
- EPI-Air (NCT01864824)
- Testing
- methyl donor
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Cervical Intraepithelial Neoplasia Grade 2, DNA Methylation
The Role of FAM19A4 and Hsa-mir-124 Methylation in Predicting Prognosis of Untreated Cervical Intraepithelial Neoplasia 2 (CIN 2)
High-risk precancerous cervical lesions are divided into stage 2 and 3 cervical intraepithelial neoplasia (CIN 2 and 3). CIN 3 represents a direct pre-stage of invasive cancer, has a high rate of progression and a high degree of…
- Trial name
- NCT05624827
- Testing
- Testing DNA methylation test for predicting prognosis of untreated CIN 2
- Where
- Slovenia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Bladder Cancer
Analysis of Urinary Methylation Patterns Via Liquid Biopsy as an Early Diagnosis Tool
Multicenter, observational, prospective, biological pilot study on liquid biopsy, aimed at investigating methylation profiles in relation to the early diagnosis of bladder cancer, to validate the potential of commercially…
- Trial name
- NCT06878027
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Off-spring Cancer Risk
Parental One-carbon Folate and Choline Nutrition Modulates Risk of Off-spring Cancer Development: Human Cohort Study
Parental one-carbon nutrient intake (folic acid and choline) and the genetic polymorphisms of one-carbon metabolic enzyme were interact with regulating embryonic one-carbon metabolic environment, affect fetal DNA and RNA…
- Trial name
- NCT02266641
- Testing
- nutrition counseling, multivitamin supplement
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital