Clinical trials: Methylation
Colorectal Cancer, Advanced Adenocarcinoma
Retrospective Analysis of Colorectal Cancer Screening Results
The purpose of this study is to retrospectively analyze colorectal cancer screening data of 40-74 year old population in Shipai Town, Dongguan City.
- Conditions
- Colorectal Cancer, Advanced Adenocarcinoma, Hyperplastic Polyp, Colorectal Neoplasms
- Trial name
- NCT05374369
- Testing
- SDC2 Gene Methylation Test and Q-FIT Test, Colonoscopy and/or pathological examination
- Where
- China
- Volunteers
- 822 people
- Sponsor
- Creative Biosciences (Guangzhou) Co., Ltd.
DNA Methylation
Comparison of the Methylation Pattern of DNA in Buccal Swabs From Different Time Points
A buccal swab will be taken using a cotton stick by rubbing it against the buccal mucosa. Samples will be taken from the same participant at different timepoints.
- Trial name
- NCT02297009
- Testing
- Buccal swab
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastrointestinal Microbiome, DNA Methylation
Analysis of Intestinal Microflora Combined With DNA Methylation in Stool to Detect Colorectal Cancer
Introduction: Colorectal cancer (CRC) has the third highest incidence rate and the fourth mortality rate in the world. Traditional colonoscopy as an invasive examination method cannot be widely used in screening for colorectal…
- Conditions
- Gastrointestinal Microbiome, DNA Methylation, Colorectal Neoplasms
- Trial name
- IMMDC (NCT04302363)
- Testing
- Fecal microbiota detection and exfoliated cell gene detection
- Where
- China
- Volunteers
- 500 people
- Sponsor
- WEIDONG LIU，MD
Geriatrics Rehabilitation
Effect of Modified Poco-Poco Exercise to Aging Biomarkers in Elderly
Subject with sarcopenia get modified poco-poco exercise program for 12 weeks
- Trial name
- NCT07042464
- Testing
- Modified poco-poco exercises
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Universitas Padjadjaran
Ewing Sarcoma Family of Tumors
Assessment of MGMT Promoter Methylation in Advanced Ewing Sarcoma Treated With Temozolomide and Irinotecan
This is a biological study in patients with advanced Ewing Sarcoma who received, according, clinical practice, temozolomide and irinotecan The O6-methylguanine-DNA methyltransferase (MGMT) methylation status, will be correlated…
- Trial name
- MGMTLiberati (NCT03542097)
- Testing
- MGMT methylation evaluation
- Where
- 5 sites in Italy, United Kingdom
- Volunteers
- 82 people
- Sponsor
- Istituto Ortopedico Rizzoli
Oral Cancer
Validation of DNA Methylation Biomarkers for Oral Cancer Detection
The aim of this study is to evaluate the association between several methylated genes and oral cancers. A prospective case control trial is designed with sample size estimated at least 160 cases.
- Trial name
- NCT01945697
- Where
- Taiwan
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aging, Mobility Disability
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
- Trial name
- BRIO (NCT06940037)
- Testing
- Progressive Resistance Training, Health Education
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Cancer With Mediastinal Lymph Node Involvement
Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging
A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by…
- Trial name
- NCT01653002
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Essen
Renal Neoplasms, Targeted Molecular Therapy
A CpG-methylation-based Assay for Stratifying Stage III Clear Cell Renal Cell Carcinoma of Receiving Adjuvant Treatment
Whether patients with stage III clear cell renal cell carcinoma(ccRCC) should receive adjuvant targeted therapy or not is still on debate.
- Trial name
- NCT02688491
- Testing
- sunitinib
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Metachronous Neoplasm, Gastric Cancer
Aberrant DNA Methylation to Predict Metachronous Gastric Neoplasms
The study is a prospective cohort study to investigate whether aberrant DNA methylation can be useful for the prediction of metachronous recurrence after endoscopic resection of gastric neoplasms (dysplasia or cancer).
- Conditions
- Metachronous Neoplasm, Gastric Cancer, Gastric Neoplasm, Aberrant DNA Methylation
- Trial name
- NCT04830618
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Healthy
Exercise-induced Changes in DNA-methylation
The purpose of the study was to investigate whether regular moderate- or high-intensity interval training can change the DNA methylation in a long-lasting state, and whether these changes affect the gene expression.
- Trial name
- NCT01931072
- Testing
- High-intensity interval training, Moderate training
- Where
- Norway
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Barrett Esophagus, Esophageal Neoplasm
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus
The purpose of this study is to determine if there are any early changes in DNA markers of blood and esophageal tissue in people with gastric reflux, Barrett's esophagus or esophageal cancer that can warn of a progression to…
- Conditions
- Barrett Esophagus, Esophageal Neoplasm, Gastroesophageal Reflux
- Trial name
- BE (NCT00431756)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Vitamin B12 Deficiency
A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by Mouth
Primary efficacy objective: To investigate the effects of a parenterally vitamin B12 combination treatment versus an oral vitamin B12 mono therapy on the vitamin B12 status in female and male patients as determined by the change…
- Trial name
- EASYVIT (NCT07029698)
- Testing
- Vitamin B12, Vitamin B6, Folic acid, Vitamin B12 (Cyanocobalamin)
- Where
- 2 sites in Ukraine
- Volunteers
- 46 people
- Sponsor
- Medice Arzneimittel Pütter GmbH & Co KG
Primary Brain Tumor
Serum DNA Analysis: Potential Application for Diagnosis and Prognosis in Brain Cancer.
Numerous studies document the ability of tumors to shed DNA into the blood stream. Circulating DNA can thus be recovered for analyses, representing a surrogate tumor material to test for potential applications in disease…
- Trial name
- NCT00265174
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Breast Cancer
DNA in Predicting Response After Systemic Therapy in Women With Metastatic Breast Cancer
RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899548
- Testing
- DNA methylation analysis, microarray analysis, polymerase chain reaction
- Where
- 4 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cystic Fibrosis
DNA Methylation and Lung Disease in Cystic Fibrosis
Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease-modifier genes and environmental exposure.
- Trial name
- METHYLCF (NCT02884622)
- Testing
- nasal epithelial, Blood sampling
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Elevated S-adenosylhomocysteine
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels
S-adenosylhomocysteine (SAH) is the end-product of methylation reactions in the body and the precursor to homocysteine. Elevated SAH in the blood is a reflection of the dysregulation of what is known as the S-adenosylmethionine…
- Trial name
- SAH (NCT05994794)
- Testing
- Alpha-GPC, Creatine and Ashwagandha (Sensoril®)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
Long COVID-19 Syndrome, Long COVID Symptoms
Epigenetic Changes in Long COVID Patients
The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine…
- Trial name
- ECLIPSE (NCT07757620)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Tension-Type Headache, Unspecified, Intractable
Tension-Type Headache Gene Expression and Methylation
Tension-type headache (TTH) refers to pain radiating from the forehead to the back of the head as a bilateral band. It often occurs without warning and spreads to the neck muscles.
- Trial name
- TTH (NCT06562855)
- Testing
- Peripheral blood sampling
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- University of Gaziantep
Hepato Cellular Carcinoma (HCC)
Hepatocellular Carcinoma Identification Using Delta-HLD
HIDE (Hepatocellular Carcinoma Identification via Delta-HLD) is a proof-of-concept case-control study designed to evaluate the performance of delta-HLD, Epiliquid's proprietary liquid biopsy technology, in detecting…
- Trial name
- HIDE (NCT07148310)
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Epiliquid Holding, Inc