Clinical trials: Methylphenidate
Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects
The aim of the ADDUCE project is to investigate any adverse effects of methylphenidate (trade name ritalin) on growth, neurological system, psychiatric states and cardiovascular system over a two year period in children and…
- Trial name
- ADDUCE (NCT01470261)
- Where
- 4 sites in Germany, Hungary and 2 more
- Volunteers
- 1,398 people, healthy volunteers welcome
- Sponsor
- NHS Tayside
Attention Deficit Hyperactivity Disorder (ADHD), Brain Computer Interface
A Brain-Computer Interface-Based Attention Training Program Compared With Methylphenidate and Citicoline
The goal of this observational study is to learn whether a brain-computer interface (BCI)-based attention training program, used alone or together with medication, can improve attention, executive functioning, and emotional…
- Trial name
- Brain-Computer (NCT07333339)
- Testing
- Brain-Computer Interface-Based Attention Training
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people
- Sponsor
- Uludag University
Attention Deficit Hyperactivity Disorder
Efficacy of Combined Treatment With CoQ10 and Methylphenidate in Children With Attention Deficit Hyperactivity Disorder
The aim of this study is to evaluate the effects of nutritional supplement co-enzyme Q10 (CoQ10) on methylphenidate-treated ADHD children in a randomized, double-blinded, placebo-controlled prospective study.
- Trial name
- NCT02315651
- Testing
- Coenzyme Q10
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Healthy Volunteers
Methylphenidate and Cognitive Training in Elderly
Currently, there is no available drug to treat the symptoms of neurodegenerative and vascular cognitive disorders that affect millions of people worldwide.
- Trial name
- PACTE-1 (NCT03280251)
- Testing
- Methylphenidate, CogniPlus software, Pseudo cognitive training
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Hypothermia, Exercise Test
The Role of Methylphenidate on Performance in the Cold
The purpose is to study the effects of dopamine activity, using methylphenidate ingestion, on exercise and cognitive function over the course of a progressive cooling protocol.
- Conditions
- Hypothermia, Exercise Test, Cognition
- Trial name
- NCT04283877
- Testing
- Methylphenidate
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brock University
HIV Dementia
A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV
This study is being done to see if a drug called long acting methylphenidate (Concerta) is safe and effective as a treatment for problems with mental function in adults infected with HIV.
- Trial name
- NCT01599975
- Testing
- Long acting methylphenidate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Relapsing Remitting Multiple Sclerosis, Multiple Sclerosis, Chronic Progressive
Evaluation of Efficiency of Ritalin in Multiple Sclerosis (MS) Patients
Scientific background: Growing awareness and accumulating data regarding the cognitive impairment and its progression in multiple sclerosis (MS) patients has received an important place in neurological research in the last decade.
- Trial name
- NCT00220493
- Testing
- Ritalin
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Sheba Medical Center
Attention Deficit Disorder With Hyperactivity
Adult Study / OROS Methylphenidate Hydrochloride (HCL) (OROS MPH) in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this study is to compare the ADHD symptom response of adults with ADHD treated with OROS MPH to those treated with placebo.
- Trial name
- NCT00937040
- Testing
- OROS MPH, OROS MPH Tablets
- Volunteers
- 357 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Attention Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder
Methylphenidate vs. Risperidone for the Treatment of Children and Adolescents With ADHD and Disruptive Disorders
Attention Deficit/Hyperactivity Disorder (ADHD) is one the most prevalent mental disorders among children and adolescents, with a prevalence of 5% in western culture.
- Conditions
- Attention Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder
- Trial name
- NCT02063945
- Testing
- Methylphenidate, Risperidone
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Sheba Medical Center
Attention Deficit Hyperactivity Disorder
Efficacy, Safety & Pharmacokinetic (PK) Study of HLD200 in Children Aged 4-5 Years With ADHD
This study will evaluate the efficacy, safety and pharmacokinetics of HLD200 (20 mg and 40 mg) in children aged 4 to 5 years with ADHD.
- Trial name
- NCT06431256
- Testing
- HLD200 methylphenidate hydrochloride capsules
- Where
- 13 sites in United States
- Volunteers
- 26 people
- Sponsor
- Ironshore Pharmaceuticals and Development, Inc
Attention Deficit Hyperactivity Disorder
Effect of Methylphenidate on Connectivity
The goal of the study is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate.
- Trial name
- NCT01764672
- Testing
- Methylphenidate
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Iris Sommer
Attention-Deficit/Hyperactivity Disorder
SNAP 25 Gene Study
To enhance our capacity to correctly choose the appropriate medication for ADHD patients on the first try based on the presence of a particular variant of a gene that could be identified on a laboratory test.
- Trial name
- NCT00885560
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) Prediction of Treatment Response
This is a 6-month trial in adults to find out if certain neuromarkers can predict individual treatment response to stimulant medications for Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT03153488
- Testing
- MRI
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
ADHD, Attention Deficit Hyperactivity Disorder
Study of Medication Patch to Treat Children Ages 6-12 With ADHD
The purpose of this study is to investigate the effectiveness of a medication skin patch called Methylphenidate Transdermal System (MTS). We will compare the MTS medicated patch to a placebo patch.
- Trial name
- NCT00586157
- Testing
- Methylphenidate Transdermal System
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Carboxylesterase 1 (CES1) Genotype, CES1 Activity
Impact of CES1 Genotype on Metabolism of Methylphenidate
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of methylphenidate, a CES1 dependent drug.
- Trial name
- NCT02147535
- Testing
- Methylphenidate
- Where
- Denmark
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME)
The Synergy Trial: Methylphenidate Plus a CFS-Specific Nutrient Formula as a Treatment for Chronic Fatigue Syndrome
The Synergy Trial will evaluate the safety and efficacy of a currently available medication (methylphenidate hydrochloride) combined with a CFS-specific dietary supplement (CFS Nutrient Formula) to treat Chronic Fatigue Syndrome…
- Trial name
- NCT01966276
- Testing
- Methyl-P plus Nutrient Formula
- Where
- 4 sites in United States
- Volunteers
- 134 people
- Sponsor
- K-PAX Pharmaceuticals, Inc.
Healthy
Open-label, Normal Healthy Volunteer Clinical Trial of a Novel Ondansetron Formulation
The goals of this open-label Phase Ia study are to evaluate the Pharmacokinetics (PK) profiles of new novel single-dose Ondansetron Pulsatile Release (Ond-PR) formulations in normal healthy volunteers.
- Trial name
- NCT01290276
- Testing
- Ond-PR1, Ond-PR1 + MPh-IR, Ond-PR2
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Tong Lee
Attention-Deficit/Hyperactivity Disorder
Comparison of Lisdexamfetamine Dimesylate With Atomoxetine HCl in Attention-Deficit/Hyperactivity Disorder (ADHD) Subjects With an Inadequate Response to Methylphenidate
This study will evaluate how long it takes for ADHD symptoms to improve in subjects who are judged by the Investigator to have had an inadequate response to methylphenidate therapy.
- Trial name
- NCT01106430
- Testing
- Lisdexamfetamine Dimesylate, Atomoxetine Hydrochloride
- Where
- 64 sites in United States, Belgium and 8 more
- Volunteers
- 267 people
- Sponsor
- Shire
Attention Deficit Hyperactivity Disorder
A Long-Term Safety Study to Evaluate Methylphenidate HCL Tablets at Multiple Dose Levels in Adults With Attention Deficit Hyperactivity Disorder
The purpose of this study is to evaluate the long-term safety of methylphenidate HCL extended-release tablets at five dose levels in adults with Attention Deficit Hyperactivity Disorder (ADHD)
- Trial name
- NCT00326300
- Testing
- methylphenidate hydrochloride extended-release tablets
- Volunteers
- 560 people
- Sponsor
- McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
Attention Deficit Hyperactivity Disorder, ADHD
Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach
The growing number of medications used to treat attention-deficit/hyperactivity disorder (ADHD) raises important questions about whether different medications have similar or different therapeutic mechanisms of action.
- Trial name
- NCT01678209
- Testing
- fMRI scans, Atomoxetine arm, Methylphenidate arm
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai