Clinical trials: Methylphenidate
Attention Deficit Hyperactivity Disorder
Quality Assurance of Administering Methylphenidate in Adults With Attention Deficit Hyperactivity Disorder (ADHD) - QUMEA
Investigation of efficacy of high-dose extended-release Methylphenidate in adults with ADHD, compared with a placebo
- Trial name
- QUMEA (NCT00730249)
- Testing
- methylphenidate hydrochloride
- Where
- 11 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Medice Arzneimittel Pütter GmbH & Co KG
Psychoactive Substances Consumption, Substance-related Disorder
French Study on COgnitive Enhancement and Consumption of Psychoactive Substances Among Youth Students
This descriptive and declarative study will help to find out consumption rates, all psychoactive substances taken together, among 18-25 year olds.
- Conditions
- Psychoactive Substances Consumption, Substance-related Disorder, Off Label-use, Cognitive Enhancement
- Trial name
- ENQUETE-COSYS (NCT02954679)
- Testing
- Online self-administrated and anonymous survey questionnaire
- Where
- France
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Attention Deficit Hyperactivity Disorder
Evaluate Long-term Safety and Efficacy of ORADUR®-Methylphenidate in Children and Adolescents With ADHD
The purpose of this study is to evaluate the long-term safety and efficacy of ORADUR®-Methylphenidate in children and adolescents with ADHD.
- Trial name
- NCT02704390
- Testing
- ORADUR®-Methylphenidate
- Where
- 3 sites in Taiwan
- Volunteers
- 64 people
- Sponsor
- Orient Pharma Co., Ltd.
Attention Deficit Hyperactivity Disorder
Comparison of Atomoxetine Plus Either Comparator or Placebo in Children With ADHD Who Haven't Responded to Stimulant Therapy
The purpose of this study is to evaluate the safety and tolerability of atomoxetine alone versus atomoxetine plus low-dose, sustained-release MPH in children with treatment-resistant ADHD.
- Trial name
- NCT00485550
- Testing
- Atomoxetine Hydrochloride, Methylphenidate Hydrochloride
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Eli Lilly and Company
Cocaine-Related Disorders, Substance-Related Disorders
Methylphenidate in the Treatment of Cocaine Dependent Patients With Adult Attention Deficit Hyperactivity Disorder - 5
The purpose of this study is the use of Methylphenidate in the treatment of cocaine dependence and Attention Deficit Hyperactivity Disorder (ADHD) comorbidity.
- Trial name
- NCT00015223
- Testing
- Methylphenidate
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pharmacological Action (PA)
The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects
1. To examine whether Ritalin has analgesic properties in healthy subjects. 2. To examine if Ritalin analgesic effect is a pain specific phenomenon or a part of a broader, non-specific effect on high mental functions.
- Trial name
- NCT01914822
- Testing
- methylphenidate hydrochloride
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Carboxylesterase 1 (CES1) Genotype, CES1 Activity
Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of two CES1 dependent drugs, enalapril and methylphenidate.
- Trial name
- NCT02135263
- Testing
- Methylphenidate, Enalapril
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Brain Injury
Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)
Traumatic brain injury (TBI) is a significant public health problem, with 1.5-2.0 million Americans injured each year. Cognitive deficits, particularly in the domains of memory and attention are frequently the source of lingering…
- Trial name
- NCT00453921
- Testing
- Methylphenidate, Memory and Attention Training
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Attention-Deficit / Hyperactivity Disorder
A Long-Term Study on Safety of JNS001 in Adults With Attention-Deficit Hyperactivity Disorder
The main purpose of this study is to evaluate long-term safety and tolerability of JNS001 at 18 to 72 mg per day in adults with Attention-Deficit/Hyperactivity Disorder (ADHD).
- Trial name
- NCT01357993
- Testing
- JNS001
- Where
- 29 sites in Japan
- Volunteers
- 253 people
- Sponsor
- Janssen Pharmaceutical K.K.
Delirium
Methylphenidate, Rivastigmine or Haloperidol in Hypoactive Delirium in Intensive Care Patients
The purpose of this pilot-trial is the feasibility of a large randomized, placebo controlled, doubleblind clinical trial to investigate the use of methylphenidate, rivastigmine or haloperidol in hypoactive ICU-delirium.
- Trial name
- NCT00599287
- Testing
- Haloperidol, Methylphenidate, Rivastigmine
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Pain
Neural Correlates of Acute Pain Dynamics
This work aims to study the neural correlates and determinants of pain dynamics related to changes in a noxious stimulus.
- Trial name
- NCT05669924
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Attention Deficit Hyperactivity Disorder, INSOMNIA
Study of the Effect of Individualizing Daytrana Wear-times on Sleep in Children With ADHD
Methylphenidate may improve sleep in children with ADHD. By leaving Daytrana (methylphenidate) patch for a longer time then 9 hours, many children report short sleep latencies and better quality of sleep.
- Trial name
- Daytsleep (NCT00989950)
- Testing
- Daytrana
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Cox Health Systems
Healthy Adult Male and Female Volunteers
Neurocognitive Effects of Extended-Release Methylphenidate in Healthy Adults
This study evaluated the effects of methylphenidate (MPH), a stimulant medication commonly used to treat attention deficit hyperactivity disorder (ADHD), in healthy adults without ADHD.
- Trial name
- NCT07742631
- Testing
- Methylphenidate Stimulant medication therapy
- Where
- South Africa
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Methylphenidate Treatment for Cocaine Abuse and ADHD - 1
Many cocaine dependent individuals are also diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Methylphenidate (Ritalin) is currently approved to treat individuals diagnosed with ADHD.
- Trial name
- NCT00136734
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- New York State Psychiatric Institute
Healthy Volunteers
An Open Label Phase I/II Study of Dopamine Transporter Receptor Occupancy With OROS and Immediate Release Methylphenidate as Measured With C-11 Altropane in Human Subjects
The specific aim of this study is to document the pharmacokinetics of DAT receptor occupancy of OROS and immediate release (IR) MPH using PET scanning with C-11 altropane as the ligand.
- Trial name
- NCT00302367
- Testing
- OROS methylphenidate hydrochloride, immediate release methylphenidate hydrochloride
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cocaine Dependence
Psychopharmacology for Cocaine Dependence - Buspirone
Chronic cocaine use may produce disruption of neurotransmitter functions (including dopamine). This may in turn contribute to measurable dysfunction in important cognitive and behavioral processes.
- Trial name
- NCT01267292
- Testing
- Buspirone, Methylphenidate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Autism, Attention Deficit Hyperactivity Disorder
A Pilot Study of Daytrana TM in Children With Autism Co-Morbid for Attention Deficit Hyperactivity Disorder (ADHD) Symptoms
This is an open-label study of the efficacy of Daytrana (methylphenidate transdermal system) for the treatment of attention and behavioral symptoms in children with Autism Spectrum Disorders.
- Trial name
- NCT00541346
- Testing
- Methylphenidate Transdermal System
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
ADHD-add
MEthylphenidate in ADHD - Addiction(s) Comorbidity: Value of Adding a Cognitive Remediation Program to Improve Short- and Medium-term Therapeutic Response
MEthylphenidate in ADHD - Addiction(s) comorbidity: benefit of adding a cognitive remediation program to improve short- and medium-term therapeutic response
- Trial name
- META (NCT06906328)
- Testing
- Cognitive remediation program, with the PRESCO® software, Control program, with the AUDITICO® software
- Where
- 6 sites in France
- Volunteers
- 248 people
- Sponsor
- Nantes University Hospital
Attention Deficit Hyperactivity Disorder
The Effect of Methylphenidate Versus Placebo on State Anxiety in Children With Attention Deficit Hyperactivity Disorder.
The purpose of the study is to explore the effect of methylphenidate on state anxiety in children with attention deficit hyperactivity disorder.
- Trial name
- NCT01798459
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center