Clinical trials: Methylphenidate
Alzheimer's Disease, Apathy
Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study
The purpose of the study is to determine the efficacy of methylphenidate over placebo in treating apathy in patients with Alzheimer's dementia.
- Conditions
- Alzheimer's Disease, Apathy, Dementia
- Trial name
- NCT00495820
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
ADHD - Combined Type
Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD
The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for…
- Trial name
- NCT04781972
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Attention Deficit Hyperactivity Disorder
OT and Social Cognition in Children With ADHD: Impact of MPH
Background: The current study aimed to explore the possible effect of stimulants on oxytocin (OT), a neuropeptide found to regulate social behavior, as a mediator of the pro-social effect of methylphenidate (MPH) in children with…
- Trial name
- NCT03788902
- Testing
- Ritalin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Diabetes Mellitus, Alzheimer's Disease
Improving Function, Quality of Life, Glycemia in Diabetics With Dementia
The primary purpose of this study is to determine if the study medication Methylphenidate (Ritalin) will improve subject's blood-sugar control by improving their motivation more than placebo.
- Conditions
- Diabetes Mellitus, Alzheimer's Disease, Apathy, Dementia
- Trial name
- NCT00792662
- Testing
- Methylphenidate
- Sponsor
- University of Nebraska
ADHD, Substance Abuse
Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)
The purpose of this study is to determine the efficacy of osmotic-release methylphenidate (OROS-MPH) versus placebo for the treatment of ADHD in adolescents with SUD.
- Trial name
- NCT00264797
- Testing
- Methylphenidate (OROS-MPH)
- Where
- 12 sites in United States
- Volunteers
- 303 people
- Sponsor
- University of Cincinnati
Attention Deficit Hyperactivity Disorder
A Multicenter Study Comparing the Efficacy and Safety of OROS Methylphenidate HCl, Ritalin (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder
The purpose of this study is to evaluate the efficacy and safety of OROS® Methylphenidate HCl as compared with placebo and standard immediate-release Ritalin® (taken three time per day) for the treatment of Attention Deficit…
- Trial name
- NCT00269802
- Testing
- OROS methylphenidate HCl, Ritalin
- Sponsor
- Alza Corporation, DE, USA
Long QT Syndrome, ADHD
Drug-induced Repolarization ECG Changes
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression.
- Conditions
- Long QT Syndrome, ADHD, Depression, Death
- Trial name
- NCT03642405
- Testing
- Electrocardiogram examination, Echocardiography, Blood Samples
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital at Herlev
Attention Deficit Hyperactivity Disorder
Endocrine Disrupting Chemicals and Hormones in ADHD
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. Growth hormone and thyroid function are associated with both physical and neurocognitive development.
- Trial name
- ADHD (NCT04970303)
- Testing
- Methylphenidate
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Childhood Apraxia of Speech
Methylphenidate in Childhood Apraxia of Speech
The purpose of this study is to describe the possible effects of methylphenidate (MPH) on speech intelligibility in children with childhood apraxia of speech (CAS) aged 6-12 years.
- Trial name
- NCT05185583
- Testing
- Methylphenidate Hydrochloride
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Murdoch Childrens Research Institute
Methamphetamine Use Disorder
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- NCT04178993
- Testing
- Methamphetamine, Methylphenidate, Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Cocaine Use Disorder
Methylphenidate-Duloxetine Combinations for Cocaine Dependence
This study will determine the influence of methylphenidate (e.g., Ritalin®) and duloxetine (Cymbalta®), alone and in combination, on the cocaine use as measured by self-report and urine drug screens.
- Trial name
- NCT02700711
- Testing
- Methylphenidate, Duloxetine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Healthy
Behavioral Differences in Effortful Control
Effortful control refers to the mental processes that help a person to regulate his or her own attention, thoughts, and emotions.
- Trial name
- BDEC (NCT01852344)
- Testing
- Methylphenidate, Easy Behavioral Task, Hard Behavioral Task
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Michigan
ADHD
Placebo-Controlled Comparison of Two Different Brands of Modified-Release Oral Dosage Forms Regarding Safety and Efficacy in Children With Attention Deficit Hyperactivity Disorder (ADHD) Aged 6 - 14
Currently two different brands of modified-release formulations are providing 50% immediate release beads/pellets and 50% extended release beads/pellets, resulting in a rapid onset and dual peak concentrations of plasma…
- Trial name
- NCT00254878
- Testing
- Methylphenidate hydrochloride
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Novartis
Dystrophia Myotonica 1
Methylphenidate in Myotonic Dystrophy Type 1
The purpose of this study is to determine whether methylphenidate is effective in the treatment of excessive daytime sleepiness due to myotonic dystrophy type 1 (DM1).
- Trial name
- NCT01421992
- Testing
- Methylphenidate
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Laval University
ADHD
The Effects of a Single Dose of Methylphenidate on Motor Performance
Aim: To evaluate the effects of MPH on young adults diagnosed with ADHD on different exercise performance tests. Hypothesis: MPH will have positive effects on motor tests requiring concentration.
- Trial name
- NCT04283604
- Testing
- MPH
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Loewenstein Hospital
Pervasive Development Disorders
Guanfacine for the Treatment of Hyperactivity in Pervasive Developmental Disorder
The purpose of this study is to determine whether guanfacine (trade name Intuniv) by itself or in combination with methylphenidate (also known as Ritalin) is helpful for treating hyperactivity in children and adolescents with a…
- Trial name
- NCT01238575
- Testing
- extended-release guanfacine
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Yale University
Language, Methylphenidate of Undetermined Intent
Language & Cognitive Control
Catecholamine (CA) neurotransmitters, such as dopamine (DA) and noradrenaline (NA), have long been implicated playing a critical role in cognitive functions, such as working memory (WM), inhibition, learning, and decision making.
- Trial name
- LCCMPH (NCT05272397)
- Testing
- Methylphenidate 20 Mg Oral Tablet, Language Task, Rest Recording
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Smoking, ADHD
Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate how nicotine, withdrawal from nicotine, and methylphenidate (a drug used for the treatment of ADHD) affect the brain of smokers with and without ADHD while doing tasks in an functional…
- Trial name
- NCT01123668
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Duke University
ADHD, Attention Deficit Hyperactivity Disorder
Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk
The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems…
- Trial name
- MPH-ATX (NCT03781765)
- Testing
- Methylphenidate, Atomoxetine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Advanced Cancer, Fatigue
Methylphenidate and a Nursing Telephone Intervention for Fatigue
The goal of this clinical research study is to learn if methylphenidate (Ritalin) can help to control fatigue caused by cancer. Its effect on other symptoms such as drowsiness, depression, sleeplessness, physical activity, and…
- Trial name
- NCT00424099
- Testing
- Methylphenidate, Nursing Telephone Intervention, Non NTI
- Where
- 2 sites in United States
- Volunteers
- 197 people
- Sponsor
- M.D. Anderson Cancer Center