Clinical trials: Methylphenidate
Epilepsy, Cognitive Deficits
Methylphenidate Treatment of Attention Deficits in Epilepsy
Methylphenidate (MPH) has long been used to improve attention and cognitive difficulties associated with ADHD, including in children with ADHD and epilepsy (Torres et al., 2008).
- Conditions
- Epilepsy, Cognitive Deficits, Attention Deficits
- Trial name
- NCT02178995
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kimford Jay Meador
Cocaine Dependence
Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET
Studies using positron emission tomography (PET) have been used with great success in demonstrating specific abnormalities in several facets of dopaminergic system function in human populations (Narendran and Martinez 2009).
- Trial name
- NCT02152670
- Testing
- Methylphenidate, Alpha Methyl Para Tyrosine (AMPT), [11C]PHNO
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Dementia, Accidental Falls
Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia.
Falls in the elderly are a very common and serious health problem with devastating consequences. Those with dementia are 5 times more likely to experience falls than older people without significant cognitive impairment.
- Conditions
- Dementia, Accidental Falls, Apathy
- Trial name
- NCT01825577
- Testing
- Transdermal Methylphenidate
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- St. Louis University
Attention Deficit Hyperactivity Disorder (ADHD)
The Effect of Methylphenidate Treatment on Oxidative Stress Levels in Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
The aim of this study is to investigate the effect of methylphenidate treatment on oxidative stress by measuring the levels of Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Oxidative Stress Index (OSI=TOS/TAS)…
- Trial name
- NCT06844812
- Testing
- This is not an interventional study. Patients who are planned to start methylphenidate treatment have been invited to participate in the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Acute Lymphoblastic Leukemia, Brain Tumors
Learning Impairments Among Survivors of Childhood Cancer
Children surviving some types of cancer have a higher risk of developing learning problems after cancer treatment than do children who have not had cancer or its treatment.
- Trial name
- NCT00576472
- Testing
- Methylphenidate
- Where
- 3 sites in United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Parkinson's Disease, Gait Impairment
Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
The purpose of this research study is to examine whether Methylphenidate (MPD) can result in improvement of gait (walking) in a population of Parkinson's Disease (PD) patients whose main disability is freezing of gait.
- Trial name
- NCT00526630
- Testing
- Methylphenidate (MPD)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Cincinnati
Attention-Deficit/Hyperactivity Disorder
Real-World Evidence of Duration of Effect of Adhansia XR (Extended-Release) for Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to investigate the treatment effectiveness of Adhansia XR at month-2 after initiation, and the effectiveness of Adhansia XR overall and when compared with the active comparator group (Concerta) over…
- Trial name
- RE-DAX (NCT04507204)
- Testing
- Adhansia XR, Concerta
- Where
- 35 sites in United States
- Volunteers
- 267 people
- Sponsor
- Purdue Pharma LP
Attention-deficit/Hyperactivity Disorder
Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder
The purpose of this study is to determine effectiveness of Vyvanse compared to Concerta in adolescents with Attention-deficit/Hyperactivity Disorder (ADHD).
- Trial name
- NCT01552915
- Testing
- Lisdexamfetamine dimesylate, Methylphenidate Hydrochloride
- Where
- 79 sites in United States
- Volunteers
- 464 people
- Sponsor
- Shire
Attention Deficit/ Hyperactivity Disorder
A Study to Evaluate Effectiveness and Safety of Prolonged Release OROS Methylphenidate in Adults With Attention Deficit Hyperactivity Disorder
The purpose of this study is to evaluate the efficacy of 2 fixed dosages of Prolonged Release (PR) OROS methylphenidate (54 and 72 mg/day) compared with placebo in adult patients with attention deficit/hyperactivity disorder…
- Trial name
- NCT00714688
- Testing
- prolonged release (PR) OROS methylphenidate 54 mg, prolonged release (PR) OROS methylphenidate 72 mg
- Where
- 42 sites in Belgium, Denmark and 9 more
- Volunteers
- 279 people
- Sponsor
- Janssen-Cilag International NV
Attention Deficit Hyperactivity Disorder, ADHD
Efficacy and Safety of Methylphenidate HCl ER Capsules in Children and Adolescents With ADHD
This multi-center parallel study is designed to study the efficacy and safety of fixed doses of methylphenidate extended release (ER) capsules of four dose levels compared with a placebo group in pediatric patients with Attention…
- Trial name
- NCT01239030
- Testing
- Methylphenidate Hydrochloride Extended Release Capsules
- Where
- 16 sites in United States
- Volunteers
- 230 people
- Sponsor
- Rhodes Pharmaceuticals, L.P.
Attention Deficit Disorder With Hyperactivity
An Efficacy and Safety Study of Osmotic Release Oral System (OROS) Methylphenidate in Participants With Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate the safety and efficacy of Osmotic Release Oral System (OROS) methylphenidate in participants with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT01012622
- Testing
- Osmotic Release Oral System (OROS) Methylphenidate Hydrochloride
- Volunteers
- 142 people
- Sponsor
- Janssen Korea, Ltd., Korea
ADHD
Evaluate the Efficacy &Safety of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD
To assess the efficacy and safety of efficacy of MTS compared to placebo
- Trial name
- NCT00499863
- Testing
- methylphenidate transdermal system
- Where
- 32 sites in United States
- Volunteers
- 217 people
- Sponsor
- Noven Therapeutics
PTSD, Stroke
Methylphenidate for Ptsd and Stroke Veterans
Veterans with post-traumatic stress disorder (PTSD) have an increased risk of developing ischemic stroke. Veterans enduring PTSD face difficulties in managing their PTSD severity after suffering from a stroke.
- Trial name
- NCT04885257
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Attention Deficit Hyperactivity Disorder
PK/PD Pediatric ADHD Classroom Study
The purpose of this study is to evaluate the association between blood drug levels and the corresponding scores of commonly used behavioral instruments based upon data collected following administration of three different…
- Trial name
- NCT02536105
- Testing
- Methylphenidate HCl ER tablets 1, Methylphenidate HCl ER tablets 2, Methylphenidate HCl ER for suspension
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Massachusetts General Hospital
Drug Interaction
Cannabidiol and CES1 Interactions in Healthy Subjects
The proposed study will assess the drug interaction potential between oral cannabidiol (Epidiolex®) and the carboxylesterase 1 (CES1) substrate methylphenidate (Ritalin®) in 12 healthy research subjects
- Trial name
- NCT04603391
- Testing
- dl-Methylphenidate plus Cannabidiol
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Florida
ADHD
Evaluate the Safety and Efficacy of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD
To evaluate the long-term, safety of Methylphenidate Transdermal System (MTS) in aged 13-17 years diagnosed withADHD
- Trial name
- NCT00501293
- Testing
- Methylphenidate Transdermal System
- Where
- 32 sites in United States
- Volunteers
- 163 people
- Sponsor
- Noven Therapeutics
Attention Deficit Hyperactivity Disorder (ADHD), Executive Function Deficits (EFD)
Memantine for Executive Dysfunction in Adults With ADHD: A Pilot Study
This is a 12-week clinical trial evaluating the efficacy and safety of memantine hydrochloride (Namenda) in the treatment of executive function deficits (EFDs) in adults with Attention Deficit Hyperactivity Disorder (ADHD)…
- Trial name
- NCT01533493
- Testing
- Memantine Hydrochloride, OROS-Methylphenidate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
ADHD - Inattentive Type, ADHD - Combined Type
Attention Deficit Disorder Medication Response Study
This study evaluates how children with Attention Deficit Disorder without Hyperactivity (ADD) respond to medication, and if their response is different from children who have problems with both hyperactivity and inattention.
- Trial name
- NCT01727414
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Fatigue in Multiple Sclerosis
Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis
Randomized, placebo-controlled, crossover, 4-sequence, 4-period, double-blind (participants and investigators), multicenter trial of 3 commonly used medications for treatment of MS-related fatigue (amantadine, modafinil…
- Trial name
- TRIUMPHANT-MS (NCT03185065)
- Testing
- Amantadine, Modafinil, Methylphenidate
- Where
- 2 sites in United States
- Volunteers
- 141 people
- Sponsor
- Johns Hopkins University
ADHD
Proton Magnetic Spectroscopy in Children and Adolescents With ADHD Before and After Treatment With OROS Methylphenidate
This will be an open label study using daily does of up to 126mg/day of Concerta in the treatment of children and adolescents, ages 12-17, who meet DSM-IV criteria for ADHD.
- Trial name
- NCT00593112
- Testing
- OROS methylphenidate, No intervention
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital