Clinical trials: Metrorrhagia
Metrorrhagia, Pelvic Pain
Surgical Myomectomy Followed by Oral Myfembree Versus Standard of Care Trial (SOUL)
In this project, the proposition is that the use of daily dosed Myfembree ( a combination of relugolix with estradiol and norethindrone acetate), FDA-approved medication to treat heavy menses fibroid-related symptoms, has the…
- Conditions
- Metrorrhagia, Pelvic Pain, Menorrhagia, Leiomyoma
- Trial name
- SOUL (NCT05538689)
- Testing
- Myfembree Oral Product
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Female Sexual Dysfunction, Endometrial Sampling
Assessment of Female Sexual Function Index (FSFI) Scores at 1 Month After Endometrial Sampling Performed Under Sedo-Analgesia or Local Anesthesia
Endometrial sampling is a commonly performed gynecological procedure used for the diagnosis of abnormal uterine bleeding and endometrial abnormalities.
- Conditions
- Female Sexual Dysfunction, Endometrial Sampling, Female Sexual Function Index (FSFI), Abnormal Uterine Bleeding, Unspecified
- Trial name
- FSFI-ENDO (NCT07628660)
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Abnormal Uterine Bleeding, Endometriosis
Performance of SYMMCORA® vs. V-Loc® Suture Material in Patients Undergoing Laparoscopic Total Hysterectomy
The aim of this study is to show the superiority of the new unidirectional barbed suture (SYMMCORA® mid-term, unidirectional) to conventional suture material in terms of time to perform the vaginal cuff closure during gynecologic…
- Conditions
- Abnormal Uterine Bleeding, Endometriosis, Uterine Prolapse, Uterine Cancer
- Trial name
- BARHYSTER (NCT06024109)
- Testing
- Closure of the Vaginal Cuff after Total Hysterectomy
- Where
- 2 sites in Germany, Spain
- Volunteers
- 132 people
- Sponsor
- Aesculap AG
Cesarean Scar Defect (Isthmococele), Pelvic Pain
Single-Layer Versus Double-Layer Uterine Closure After Primary Cesarean Section
This study compares two surgical techniques for closing the uterus after cesarean section: single-layer versus double-layer closure.
- Conditions
- Cesarean Scar Defect (Isthmococele), Pelvic Pain, Spotting, Amenorrhea Secondary
- Trial name
- NCT07611331
- Testing
- Double-layer hysterorrhaphy at primary cesarean section, Single-layer hysterorrhaphy at primary cesarean section
- Where
- Tunisia
- Volunteers
- 384 people
- Sponsor
- Hédi Chaker Hospital
Uterine Bleeding, Uterine Cancer
Measurement of Urinary Hormones in Patients With Abnormal Uterine Bleeding to Study Uterine Cancer Progression
The investigators will obtain urine hormone results and validated menstrual bleeding score from people experiencing abnormal uterine bleeding. The investigators will evaluate satisfaction and ease of use of Mira monitor.
- Conditions
- Uterine Bleeding, Uterine Cancer, Uterine Neoplasms, Endometrial Cancer
- Trial name
- MIRA (NCT07581288)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Abnormal Uterine Bleeding Due to Adenomyosis (Disorder)
Radiofrequency Endometrial Ablation or Uterine Artery Embolization for Treatment of Adenomyosis-related Abnormal Uterine Bleeding
The present study aims to compare the efficacy (menstrual blood loss, pain, quality of life) and the safety (complications, recovery) of each conservative intervention (RFA, UAE) versus hysterectomy for the treatment of…
- Trial name
- ADENOTREAT (NCT07195305)
- Testing
- Radiofrequency endometrial ablation, Uterine artery embolization, Hysterectomy
- Where
- 4 sites in France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Bordeaux
Endometrial Cancer
Detection of Endometrial Cancer Through Risk Modelling
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention.
- Trial name
- DETECTR (NCT06268626)
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intrauterine Device Expulsion, Adenomyosis, Endometriosis
Clinical Observation of Hysteroscopy-Assisted Placement of Handmade Frameless GyneFix-LNG-IUS (Retrospective Cohort)
This is a retrospective self-controlled observational study. We evaluated the safety and efficacy of a handmade frameless levonorgestrel-releasing intrauterine system (GyneFix-LNG-IUS) in patients at high risk of IUD expulsion.
- Conditions
- Intrauterine Device Expulsion, Adenomyosis, Endometriosis, Menorrhagia, Dysmenorrhea, Abnormal Uterine Bleeding
- Trial name
- Gyne-LNG-IUS (NCT07518693)
- Testing
- Handmade Frameless GyneFix-LNG-IUS
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Yu Wang
Abnormal Uterine Bleeding, Unspecified, Benign Gynecological Disease
The Learning Curve of a Gynecology and Obstetrics Resident Performing Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) Hysterectomy in a University Hospital
This prospective observational study aims to evaluate the learning curve of obstetrics and gynecology residents performing Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) hysterectomy in a university hospital…
- Conditions
- Abnormal Uterine Bleeding, Unspecified, Benign Gynecological Disease, Adenomyosis of Uterus, Uterine Leiomyomas
- Trial name
- LC of V-NOTES (NCT07465822)
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Cukurova University
Abnormal Uterine Bleeding, Cesarean Section Complications
Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding
The purpose of the study is to compare the clinical efficacy and niche morphological changes following treatment with combined oral contraceptive pills (OCPs) versus a levonorgestrel-releasing intrauterine system (LNG-IUS) in…
- Conditions
- Abnormal Uterine Bleeding, Cesarean Section Complications, Uterine Scar
- Trial name
- NCT07229209
- Testing
- transvaginal ultrasonography, monophasic combined oral contraceptive pill, 52 mg levonorgestrel-releasing intrauterine system
- Where
- Egypt
- Volunteers
- 166 people
- Sponsor
- Benha University
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Pipelle Versus Karman Endometrial Biopsy Under Standardized Paracervical Block
Endometrial biopsy is a commonly used outpatient procedure to evaluate abnormal uterine bleeding and postmenopausal bleeding. Different sampling methods are available, but their diagnostic adequacy and patient experience may…
- Trial name
- PB-EMB (NCT07366814)
- Testing
- Pipelle Endometrial Biopsy, Karman Cannula Endometrial Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Abnormal Uterine Bleeding
Comparison of Manual Vacuum Aspiration and Dilatation and Curettage for Endometrial Sampling Adequacy in Women With Abnormal Uterine Bleeding
This randomized controlled trial was conducted in the Department of Obstetrics and Gynecology, Sheikh Zayed Hospital, Rahim Yar Khan, to compare two commonly used methods for obtaining endometrial tissue in women aged 30 to 60…
- Trial name
- NCT07349108
- Testing
- Manual Vacuum Aspiration, Dilatation and Curettage
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Sheikh Zayed Medical College
Endometrial Cancer, Abnormal Uterine Bleeding
ONSD as an ICP Marker in vNOTES and TLH
Patients undergoing conventional total laparoscopic hysterectomy (TLH) are typically placed in the Trendelenburg position with intraabdominal carbon dioxide (CO₂) insufflation.
- Conditions
- Endometrial Cancer, Abnormal Uterine Bleeding, Myoma;Uterus
- Trial name
- NCT07250178
- Testing
- vNOTES, TLH
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Scar Niche, Abnormal Uterine Bleeding
Sublingual Misoprostol Versus No Cervical Priming Before Hysteroscopic Resection of Symptomatic Uterine Niches
The purpose of the study is to evaluated whether preoperative sublingual misoprostol can enhance the effectiveness and safety of niche resection in patients with symptomatic uterine niche.
- Conditions
- Scar Niche, Abnormal Uterine Bleeding, Cesarean Section Complications
- Trial name
- NCT07271056
- Testing
- Misoprostol 200mcg Tab, Hysteroscopic resection of uterine niche, Saline-infusion Sonohysterography
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Benha University
Abnormal Uterine Bleeding
Evaluation of Safety, Efficacy, and Pharmacokinetics of BT-114143 Injection in Patients With Abnormal Uterine Bleeding
This is a randomized, double-blind, placebo-controlled, multiple-dose escalation, Phase Ib clinical study conducted in patients with abnormal uterine bleeding (e.g., AUB).
- Trial name
- NCT07169214
- Testing
- BT-114143 Injection at low dose, BT-114143 Injection at Medium-dose, BT-114143 Injection at High-dose
- Where
- China
- Volunteers
- 39 people
- Sponsor
- ScinnoHub Pharmaceutical Co., Ltd.
Menstruation Disturbances, Metrorrhagia
Transdermal Ethinyl Estradiol and Norelgestromin for Irregular Bleeding in Contraceptive Implant Users
The goal of this clinical trial is to evaluate the effectiveness of transdermal contraceptive patches in treating irregular vaginal bleeding in women over 18 years old who are using contraceptive implants and experiencing…
- Conditions
- Menstruation Disturbances, Metrorrhagia, Uterine Hemorrhage, Contraception Behavior
- Trial name
- NCT07083635
- Testing
- Transdermal Ethinyl Estradiol/Norelgestromin Patch
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University
Abnormal Uterine Bleeding, Dysmenorrhea
Failed Endometrial Ablation Treatment With Implantable Progesterone (FEAT) Study
The objective of this study is to assess the efficacy of an implantable etonogestrel device in reducing hysterectomy rate in patients with a failed endometrial ablation.
- Trial name
- FEATS (NCT05227456)
- Testing
- Etonogestrel 68mg implant
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Cesarean Section Complications, Abnormal Uterine Bleeding
Combined Hystroscopic and Laparoscopic Repair of CS Scar Disorder
Combined hystroscopic and laparoscopic repair of symptomatic uterine Niche as new technique to maximize resolution of symptoms after niche repair with concomitant increase in RMT
- Trial name
- NCT07183501
- Testing
- Combined hystroscopic and laparoscopic repair
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Fibroid Uterus, Metrorrhagia
A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes
The goal of this randomized clinical trial is to assess the outcomes of total laparoscopic hysterectomy vs subtotal laparoscopic hysterectomy + mini-laparotomy for uterine extraction for benign gynecological conditions in terms…
- Conditions
- Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm
- Trial name
- STORY (NCT06802198)
- Testing
- total hysterectomy, subtotal hysterectomy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Abnormal Uterine Bleeding
Management of Abnormal Uterine Bleeding
Abnormal uterine bleeding "AUB" describes all abnormal forms of menstrual bleeding which may result from several causes including anovulation, problems related to pregnancy, infections, vaginal and cervical abnormalities, uterine…
- Trial name
- NCT06369012
- Testing
- Mefenamic acid 500 mg
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Egymedicalpedia