Clinical trials: Microbial Colonization
HIV Infections
A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients
To determine the proportion of patients whose plasma HIV-1 RNA level falls below the level of detection (< 400 copies/ml) at week 24 of study therapy.
- Trial name
- NCT00002378
- Testing
- Ritonavir, Nelfinavir mesylate, Saquinavir
- Where
- 102 sites in United States, Germany and 4 more
- Volunteers
- 825 people
- Sponsor
- Hoffmann-La Roche
Dengue, Dengue Fever
Risk Factors for Hospitalization and Transfusion Criteria in Patients With Dengue Virus Infection
This 3-year prospective observational study aims to identify clinical and laboratory risk factors associated with hospitalization in patients with confirmed dengue virus infection.
- Conditions
- Dengue, Dengue Fever, Dengue Fever With Warning Signs
- Trial name
- DENGUE-FACT (NCT07007585)
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Jose Ivan Rodriguez de Molina Serrano
Gingiva; Infection, Plaque, Dental
Role of Herbal Dentifrices in the Management of Plaque Induced Gingivitis
The clinical cross over study involves the use of two herbal based dentifirices moringa and miswak and its efficacy in reducing plaque induced gingivitis.
- Trial name
- NCT04830176
- Testing
- dentifrice
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajman University
Tinea
Clinical Assessment of Oxiconazole Nitrate Solid Lipid Nanoparticles Loaded Gel
Clinical study for the developed oxiconazole nitrate solid lipid nanoparticles (SLNs) gel system compared to the corresponding marketed product was conducted on 28 patients with different types of tinea fungal infection.
- Trial name
- NCT03823040
- Testing
- Oxiconazole Nitrate Cream 1%, Oxiconazole nitrate SLNs loaded gel.
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Minia University
HIV/AIDS
Evaluating Demand Creation Strategies for Voluntary Medical Male Circumcision (VMMC) in Kenya
The purpose of this study is to evaluate the impact of two interventions - Inter-Personal Communication [IPC] and Dedicated Service Outlets [DSOs] - in recruiting men aged 25-39 years for Voluntary Medical Male Circumcision…
- Trial name
- TASCO (NCT02497989)
- Testing
- Inter-personal Communication (IPC), Dedicated Service Outlets (DSO)
- Where
- Kenya
- Volunteers
- 2,785 people, healthy volunteers welcome
- Sponsor
- Impact Research & Development Organization
HIV Infection, Antiretroviral Treatment
Nevirapine / Lamivudine for HIV Maintenance Therapy
The standard treatment for HIV infection involves taking a combination of three HIV drugs. The main reason for using multiple substances is to prevent resistance from developing rapidly when only one or two drugs are used.
- Conditions
- HIV Infection, Antiretroviral Treatment, Maintenance Therapy
- Trial name
- NCT07014189
- Testing
- Neviparine (NVP)/ Lamivudine (3TC)
- Where
- Switzerland
- Volunteers
- 201 people
- Sponsor
- Cantonal Hospital of St. Gallen
Staphylococcus Aureus
Preventing the Spread of Infection in Nursing Homes
This study evaluates the feasibility of targeting more frequent gown and glove use for specific high risk moments of care in specific nursing home residents in order to prevent Staphylococcus aureus (SA) acquisition and infection.
- Trial name
- NCT03319368
- Testing
- Targeted gown and glove use
- Where
- 2 sites in United States
- Volunteers
- 367 people
- Sponsor
- University of Maryland, Baltimore
HIV, HIV Infections
Efficacy of Tenofovir Alafenamide Versus Placebo Added to a Failing Regimen Followed by Treatment With Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Atazanavir in HIV-1 Positive, Antiretroviral Treatment-Experienced Adults
The primary objective of this study is to evaluate the efficacy of tenofovir alafenamide (TAF) versus placebo, each administered with the existing, failing antiretroviral (ARV) regimen.
- Conditions
- HIV, HIV Infections, Acquired Immunodeficiency Syndrome
- Trial name
- NCT01967940
- Testing
- TAF, E/C/F/TAF, Current failing ARV regimen
- Where
- 15 sites in United States, Dominican Republic and 3 more
- Volunteers
- 55 people
- Sponsor
- Gilead Sciences
HIV-1-infection
HIV Persistence in Lymph Node and Peripheral Blood
The aim of this project is to determine whether latent HIV is enriched in cells expressing certain proteins (receptors) on their surface and whether it is possible to eliminate these cells through the use of drugs that…
- Trial name
- HIV-PRADA (NCT03426189)
- Testing
- Leukapheresis, Lymph node biopsy
- Where
- Australia
- Volunteers
- 8 people
- Sponsor
- University of Melbourne
Non-infectious Uveitis, Periodontal Disease
Periodontal Status and Cytokine Levels in Patients With Non-Infectious Uveitis
This cross-sectional observational study aimed to evaluate periodontal clinical parameters and inflammatory cytokine levels in gingival crevicular fluid (GCF), saliva, and serum in patients with non-infectious uveitis (NIU)…
- Trial name
- NIU-PERIO (NCT07480291)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Selcuk University
HIV-1 Infection
Dose Ranging, Switch Study of Islatravir (MK-8591) and Ulonivirine (MK-8507) Once-Weekly in Virologically-Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) [MK-8591-013]
This is a randomized, controlled, double-blind, study to evaluate the safety and tolerability of islatravir (ISL) + ulonivirine based on review of the accumulated safety data, in adult participants with human immunodeficiency…
- Trial name
- NCT04564547
- Testing
- Islatravir, Ulonivirine, BIC/FTC/TAF
- Where
- 23 sites in United States, France and 1 more
- Volunteers
- 161 people
- Sponsor
- Merck Sharp & Dohme LLC
Human Papillomavirus Infection, HPV
Human Papillomavirus in Young People Epidemiological Research 4
Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV.
- Conditions
- Human Papillomavirus Infection, HPV, HPV Infection, Anal Cancer
- Trial name
- HYPER4 (NCT05587738)
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Monash University
Bacterial Infection, HIV
Preventing Bacterial and Viral Infections Among Injection Drug Users
We propose a randomized controlled trial (RCT) of the Skin intervention, compared to an assessment-only condition (both groups receive rapid HIV testing, a review of testing results, and brief HIV prevention counseling) among 350…
- Trial name
- NCT01892358
- Testing
- SKIN Intervention, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- Butler Hospital
Influenza Virus Infection, Trained Immunity
Effects of BCG on Influenza Induced Immune Response
In the present study, the investigators want to investigate whether prior BCG-vaccination improves the efficacy of influenza ("the flu") vaccination in young and/or old healthy volunteers and consequently could protect against…
- Trial name
- NCT02114255
- Testing
- BCG
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Convalescence, Corona Virus Infection
Convalescent Plasma Therapy in Patients With COVID-19
Scientists and medical workers all around the world were running out of time to manage COVID-19. Several studies have been done to understand the disease and ultimately to find possible treatment.
- Conditions
- Convalescence, Corona Virus Infection, Plaque
- Trial name
- NCT04407208
- Testing
- Convalescent plasma
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Biofarma
Hepatitis B, Chronic
Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients
This study evaluates generic emtricitabine(FTC) in Chinese naive children chronic hepatitis B patients. Single group of child patients were enrolled, which include HBeAg positive and negative Chronic hepatitis B(CHB)group.
- Trial name
- NCT02327676
- Testing
- Emtricitabine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Asian-Pacific Alliance of Liver Disease, Beijing
Hidradenitis Suppurativa
The Ohio State University Dermatology Biorepository
This study will create and extend a source of clinical specimens for the future study of inflammatory skin disorders.
- Trial name
- NCT03146676
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Ohio State University
HIV/AIDS
Minority AIDS Initiative Retention and Re-Engagement Project
The purpose of this study is to determine whether an enhanced peer intervention is effective in retaining and re-engaging at-risk people of color living with HIV/AIDS into care.
- Trial name
- NCT01616940
- Testing
- Enhanced Peer Intervention
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 348 people
- Sponsor
- Boston University
Chronic Obstructive Pulmonary Disease
Infectious Etiology of Acute Exacerbations of COPD
To assess the infectious etiology related to acute exacerbation of COPD in Hong Kong
- Trial name
- NCT00441389
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Tinea Capitis
Selenium Sulfide, Ketoconazole and Ciclopirox Shampoo as Additional Treatments for Tinea Capitis (Scalp Ringworm)
Antifungal shampoos have been used as supplements to oral griseofulvin to help eradicate tinea capitis (also known as ringworm of the scalp) more quickly.
- Trial name
- NCT00127868
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Chen, Catherine, M.D.