Clinical trials: Microbiome, open to volunteers
Alzheimer Disease Related Dementia
Probiotic Milk Drink for Gut and Brain Health in Older Adults and Caregivers
This double-blind, randomized, placebo-controlled clinical trial will evaluate the effects of a probiotic fermented milk (PFM) drink on gut and brain health in individuals with Alzheimer's disease and related dementias (ADRD) and…
- Trial name
- PFM (NCT07800195)
- Testing
- Probiotic Fermented Milk (PFM) Drink
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Unresectable Melanoma
Prebiotic Food-enriched Diet (PreFED) to Enhance the Microbiome and Response to First-line Immunotherapy in Unresectable Melanoma
To learn about the possible effects of a prebiotic food-enriched diet (PreFED) targeting the gut microbiome in participants with melanoma who are starting immune checkpoint blockade (ICB) therapy.
- Trial name
- NCT06466434
- Testing
- Prebiotic Food-Enriched Diet
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- M.D. Anderson Cancer Center
Nutritional and Metabolic Diseases, Overweight
The FaibaGo Study - Long-Term Weight Reduction Via Low-Threshold Intervention
The main aim of this study is to assess the effect of a chewing gum containing galactooligosaccharides (GOS) on the body mass index (BMI), the metabolism and the oral and intestinal microbiomes in a population of overweight…
- Trial name
- NCT07036692
- Testing
- FibreGum
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Bern
Microbiome Analysis
Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption
The goal of this observational study is to learn if a ketone ester can improve the content of the gut microbiome. The main questions it aims to answer are: Does a ketone ester reduce age-related signatures in the gut microbiome?…
- Trial name
- BREAK (NCT06954675)
- Testing
- Exogenous ketone ester
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity & Overweight, Metabolic Syndrome
Kodo Millet Porridge and Its Effects on Gut Health and Metabolic Syndrome
Dietary fiber are components in foods that are not digested by human gastrointestinal enzymes (alpha amylase and alpha glucosidase) but are instead broken down and fermented by gut microbes.
- Conditions
- Obesity & Overweight, Metabolic Syndrome, Gut Dysbiosis, Insulin Resistance
- Trial name
- KMGMS (NCT07703371)
- Testing
- Kodo Millet Porridge Beverage
- Where
- India
- Volunteers
- 50 people
- Sponsor
- JSS MEDICAL COLLEGE, JSS ACADEMY OF HIGHER EDUCATION AND RESEARCH
Kidney Transplant Symptoms, Gut Microbiome
The Gut Microbiome and Serum Metabolites as a Biological Mechanism Underlying Pain in Kidney Transplantation
Study Summary Nearly half (47%) of people with end-stage kidney disease (ESKD) whose kidney function is restored after kidney transplantation experience chronic pain compared to 19% of adults in the US general population.
- Trial name
- BIOME-KT (NCT06206486)
- Testing
- no intervention, observational
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Illinois Chicago
Inflammatory Bowel Disease (IBD)
Omics-driven Research on the Gut-Oral Microbiome, Metabolome, Lifestyle, and Clinical Integration in Korean Inflammatory Bowel Disease
The inflammatory bowel disease (IBD) is a condition that afflects approximately 5 million people worldwide, with 1.4 million in the US and 2.2 million in Europe.
- Trial name
- ORIGIN (NCT06124833)
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Chang Kyun Lee
Healthy Adult Participants
Probiotic Research for Mental Health in Adult Volunteers
This randomized, double-blind, placebo-controlled pilot study will evaluate the effects of four weeks of supplementation with a probiotic on mental health in healthy adults aged 18-30 years.
- Trial name
- NCT07751614
- Testing
- Probiotic
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Bacterial Contamination
Bacterial Mask Contamination in Operating Room
The primary objective of this study is to determine whether surgical mask configuration policy-compliant (up or off ) versus mask dangling is associated with differences in bacterial contamination among unscrubbed operating room…
- Trial name
- NCT07900958
- Testing
- Mask up or off, Mask dangling
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Overactive Bladder (OAB), Urge Incontinence
Assessing the Genitourinary Microbiome of Women With Overactive Bladder Undergoing Onabotulinum Toxin Type A Intradetrusor Injections
Single-site prospective observational pilot feasibility study of women with overactive bladder/urge urinary incontinence undergoing onabotulinum toxin type A intradetrusor injections in order to achieve the following objectives…
- Trial name
- MICROAB_Pilot (NCT07025044)
- Testing
- onabotulinum toxin type a
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Alexis Dieter
Mild Cognitive Impairment, Alzheimer Disease (AD)
Microbiome in Aging of Gut and Brain
The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease (AD), Dementia
- Trial name
- MiaGB (NCT07799402)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Parkinson Disease
Exploring the Relationship Between L-dopa Responsiveness and Small Intestinal Microbiome in Parkinson's Disease
The investigators hypothesize that small intestinal (SI) microbiome biomarkers predict the responsiveness to oral levodopa/carbidopa in people with Parkinson's disease (PwPD).
- Trial name
- LENSER (NCT06762028)
- Testing
- SIMBA capsule
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Bioavailability, Gut Microbiome
Curcumin and Retinal Study
To test how two weeks of curcumin supplementation would cross the blood brain barrier (BBB) and attach to amyloid beta proteins, to assess the feasibility (safety and bioavailability), and to explore the resulting…
- Conditions
- Bioavailability, Gut Microbiome, Safety
- Trial name
- NCT05774704
- Testing
- Low curcumin group, High curcumin group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Genitourinary Syndrome of Menopause
Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause
Chronic hypoestrogenism in postmenopausal women significantly impacts the urogenital epithelium, leading to Genitourinary Syndrome of Menopause (GSM) and increasing susceptibility to gynecological infections due to vaginal pH…
- Trial name
- NCT06873971
- Testing
- Topical estrogen therapy based on estriol (E3), Active Er:YAG Laser
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Symbiotic, Uremic Toxins
Modulation of Gut Microbiota Composition and Gut Permeability Profiles by Multispecies Synbiotic Supplementation in Hemodialysis Patients
Chronic kidney disease (CKD) patients undergoing maintenance hemodialysis experience profound alterations in their gut microbiota, leading to dysbiosis and increased gut permeability.
- Conditions
- Symbiotic, Uremic Toxins, Gut -Microbiota, Gut Permeability
- Trial name
- NCT07461233
- Testing
- Multispecies Synbiotic Supplementation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Vaginal Microbiome
The Maggie Project: Exploring the Origin and Heredity of the Vaginal Microbiome
The vaginal microbiome plays a crucial role in women's health and reproduction, impacting not only women but also their partners and children. However, its ecology and primary colonizers are not well understood.
- Trial name
- Maggie (NCT06912126)
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Major Depressive Disorder (MDD)
Implementation of a Multiple Intervention to Promote Healthy Lifestyles in Patients With Depression
This clinical trial aims to investigate whether an integrative approach combining education on the Mediterranean diet and physical activity (PA) can significantly reduce depressive symptomatology in individuals with major…
- Trial name
- NCT06990035
- Testing
- Mediterranean diet lessons program, Physical activity
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA)
A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization
Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays, and increased healthcare costs.
- Conditions
- Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococci, Carbapenem-Resistant Enterobacteriaceae
- Trial name
- MDRO-Fiber (NCT07792915)
- Testing
- Resistant Potato Starch, Maltodextrin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Gut Microbiome, Healthy Adult Male
Effect of Antifungals on the Intestinal Microbiome - a Randomized, Controlled, Proof-of-concept Trial
The goal of this clinical trial is to learn how the antifungal drug fluconazole affects the gut microbiome and immune system in healthy volunteers.
- Conditions
- Gut Microbiome, Healthy Adult Male, Antifungal Therapy
- Trial name
- FAME (NCT07295314)
- Testing
- Fluconazole 200mg tab
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)