Clinical trials: Microbiome Composition
Diet Habit, Microbial Colonization
Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity
Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship.
- Conditions
- Diet Habit, Microbial Colonization, Activity, Motor
- Trial name
- PerOME (NCT04766528)
- Testing
- 3 maximal aerobic tests
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypertension, Type 2 Diabetes
Military Health and Nutrition Examination Study
The Military Health and Nutrition Examination Study (MHANES) is a Department of Defense funded study conducted by Pennington Biomedical Research Center and the US Army Research Institute of Environmental Medicine.
- Conditions
- Hypertension, Type 2 Diabetes, Dyslipidemias, Cardiovascular Diseases
- Trial name
- MHANES (NCT06380322)
- Where
- 6 sites in United States
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Inflammation, Women's Health
Effects of Fermented Vegetables on Gut Microflora and Inflammation in Women
This proposal will examine whether daily consumption of fermented vegetables for 6 weeks can impact the gut microflora and markers of inflammation of women between the ages of 18-70 years.
- Conditions
- Inflammation, Women's Health, Gastrointestinal Microbiome
- Trial name
- NCT03407794
- Testing
- Fermented vegetable, Non-fermented vegetable
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of North Florida
Obesity, Diabetes
Effects of Non-nutritive Sweeteners on the Composition of the Gut Microbiome
This pilot study is being conducted to evaluate whether consumption of diet soda sweetened with sucralose and acesulfame-potassium leads to changes in the gut microbiota.
- Trial name
- NCT02877186
- Testing
- commercially-available diet soda, carbonated water (control)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- George Washington University
Sclerosis, Multiple
Gut Microbiota Composition, Cognitive Function, and Physical Fitness in Multiple Sclerosis Patients
The evidence suggests that multiple sclerosis (MS) induces a decline in motor and cognitive function and provokes a shift in gut microbiome composition in patients.
- Trial name
- MSDANCE (NCT06220409)
- Testing
- Dance classes
- Where
- Slovakia
- Volunteers
- 29 people
- Sponsor
- Comenius University
Diet, Healthy
The Effects of Dietary Fibres on Metabolic Health and the Gut Microbiome
The study involves intake of dietary supplements, which are commonly found in the UK diet (not pharmacological agents) to test their effects on inflammation in the body and gut microbiome composition.
- Conditions
- Diet, Healthy, Systemic Inflammatory Response
- Trial name
- NCT06580132
- Testing
- Pectin, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Healthy Diet, Gastrointestinal Microbiome
Study the Effect of Water Kefir Consumption on the Gut Microbiome in Healthy Adults
The goal of this intervention study is to analyse the microbiota composition after the water kefir consumption. The main questions are to evaluate the potential probiotic drink can have beneficial effect on the gut microbiota.
- Conditions
- Healthy Diet, Gastrointestinal Microbiome, Probiotics
- Trial name
- NCT05657730
- Testing
- Water Kefir beverage
- Where
- Sweden
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lund University
Cardiogenic Shock, Microbial Colonization
Influence of Enteral Microbiome on Mortality of Patients With Cardiogenic Shock
Cardiogenic shock is associated with a high mortality. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects.
- Conditions
- Cardiogenic Shock, Microbial Colonization, Out-Of-Hospital Cardiac Arrest, Acute Heart Failure
- Trial name
- NCT06006754
- Testing
- Observational study
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Essen
Periodontitis
Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities
The purpose of this study is to characterize the effect of minocycline microspheres (MM) administered as an adjunct to scaling and rooting planning (SRP) on the subgingival community composition and metatranscriptome functional…
- Trial name
- NCT05422742
- Testing
- SRP + MM, Scaling and Root Planing (SRP)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Probiotics
Effect of Probiotic Administration on Gut Flora Composition
Healthy human gut contains a large number of bacteria, which belong to several different species. Some genes in these bacteria encode enzymes that the human body cannot produce.
- Trial name
- NCT03330678
- Testing
- Probiotic (VSL#3)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Liver Cirrhosis
The Impact of a Dietary Fiber Enriched Diet on the Outcome of Patients with Liver Cirrhosis
The goal of this dietary intervention is to study the impact of a dietary fiber enriched diet on the intestinal dysbiosis, systemic inflammation and cirrhosis-related complications in patients with liver cirrhosis.
- Trial name
- ChainCirr (NCT06634186)
- Testing
- Dietary intervention
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Hannover Medical School
Preterm Birth, Neurodevelopmental Disorders
Guangzhou Preterm and Term Birth Cohort Study
The Guangzhou Preterm-Term Birth Cohort (GPTBC) is a prospective observational study of how early-life nutrition, environmental exposures, and family factors relate to the health and development of preterm and term infants and…
- Conditions
- Preterm Birth, Neurodevelopmental Disorders, Overweight, Obesity
- Trial name
- GPTBC (NCT07756177)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Colon Cancer
MIMICC Study in Patients With Colorectal Cancer
This multicenter prospective interventional study will evaluate stool and saliva microRNA expression and microbiome composition in patients with histologically confirmed colon or rectal cancer during key phases of the diagnostic…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancers
- Trial name
- MIMICC (NCT07494201)
- Testing
- Prospective Biological Sample Collection and Longitudinal Molecular Profiling, Diet and Lifestyle Assessment
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pancreatic Cancer
Personalised Nutritional Care in Older Patients With Pancreatic Ductal Adenocarcinoma
NutriCa65-PDAC is a clinical study for patients aged 65 years or older with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.
- Trial name
- NutriCa65-PDAC (NCT07821554)
- Testing
- Experimental: Personalised nutritional care delivered by a trained dietitian
- Where
- 5 sites in Denmark, Italy and 3 more
- Volunteers
- 250 people
- Sponsor
- Inna Chen, MD
Diabetes, Heart Diseases
Personalised Responses to Dietary Composition Trial
The foods we eat - our diet - can affect whether we develop diseases during our lives, such as diabetes or heart disease. This is because the amount and types of foods we eat can affect our weight, and because different foods are…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- PREDICT (NCT03479866)
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diet, Healthy, Metabolic Disease
Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism
The aim of this study is to investigate how a short versus a long transit time impacts the gut microbiome's response to a high-fiber and a low-fiber diet, respectively.
- Trial name
- PRIMA-KOST (NCT06022302)
- Testing
- Diet + laxative, Diet only
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metabolic Effects, Immunosuppressive Agents
Impact of SCFA Supplementation on Gut Microbiome Composition of Kidney Transplant Recipients
This is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of high-dose short-chain fatty acid (SCFA) supplementation on the gut microbiome and host metabolome in stable kidney…
- Conditions
- Metabolic Effects, Immunosuppressive Agents, Renal Function, Adverse Events
- Trial name
- RENOBIOME (NCT07024238)
- Testing
- SCFA
- Where
- Slovakia
- Volunteers
- 41 people
- Sponsor
- University Hospital, Martin
Depression, Anxiety
The Influence of Probiotic Supplementation on the Severity of Anxiety and Depressive Symptoms, as Well as the Function and Composition of Gut Microbiota, Metabolic, Inflammation, and Oxidative Stress Markers in Patients With Depression
The aim of this study is to gather empirical evidence which will enable to evaluate the impact of probiotic supplementation on the severity of anxiety and depressive symptoms, function, and composition of gut microbiota…
- Trial name
- NCT05717946
- Testing
- Probiotic composed of two bacteria strains: Lactobacillus helveticus Rosell and Bifidobacterium longum Rosell., control group
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Alzheimer Disease, Intestinal Microbiota
Taxonomic and Functional Composition of the Intestinal Microbiome: a Predictor of Rapid Cognitive Decline in Patients With Alzheimer's Disease
The objective of the study is to highlight a modification of the composition of the intestinal microbiota associated with the diagnosis of Alzheimer's disease and its most unfavorable form, Rapid Cognitive Decline (DCR).
- Trial name
- MiDCR (NCT03487380)
- Testing
- Fecal sample collection
- Where
- 2 sites in France
- Volunteers
- 86 people
- Sponsor
- Nantes University Hospital