Clinical trials: Microcephaly, open to volunteers
Neuromotor Impairments, Cerebral Palsy
The FBRI VTC Neuromotor Research Clinic
The FBRI VTC Neuromotor Research Clinic was established and opened in May of 2013 to provide intensive therapeutic services to individuals with motor impairment secondary to neuromotor disorders. It is direct by Dr.
- Conditions
- Neuromotor Impairments, Cerebral Palsy, Microcephaly, Autism
- Trial name
- NCT03325946
- Testing
- ACQUIRE Therapy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Virginia Polytechnic Institute and State University
COPD
Effects of Manual Positive End Expiratory Pressure and Non-invasive Continuous Positive Air Pressure in COPD Patients
This randomized clinical trial aims to compare the effectiveness of Manual Positive End Expiratory Pressure (PEEP) and Non-Invasive Continuous Positive Airway Pressure (CPAP) in patients with Chronic Obstructive Pulmonary Disease…
- Trial name
- NCT07079527
- Testing
- Manual Positive End Expiratory Pressure (PEEP) Therapy, Non-Invasive CPAP Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Intellectual Disability, Epilepsy
MEHMO Natural History and Biomarkers
This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have…
- Conditions
- Intellectual Disability, Epilepsy, Hypogonadisms, Microcephaly
- Trial name
- NCT06019182
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
MOPDII, Meier-Gorlin Syndrome
Primordial Dwarfism Registry
The goal of this registry is to collect information on individuals with forms of microcephalic primordial dwarfism as well as related conditions.
- Conditions
- MOPDII, Meier-Gorlin Syndrome, Saul-Wilson Syndrome, Microcephalic Primordial Dwarfism
- Trial name
- NCT04569149
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Nemours Children's Clinic
Spasticity, Muscle, Microcephaly
Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)
MELPIDA is proposed for the treatment of subjects with SPG50 and targets neuronal cells to deliver a fully functional human AP4M1 cDNA copy via intrathecal injection to counter the associated neuronal loss.
- Conditions
- Spasticity, Muscle, Microcephaly, Intellectual Deficiency, Growth Retardation
- Trial name
- NCT05518188
- Testing
- MELPIDA
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Elpida Therapeutics SPC
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment
CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial
Obstructive sleep apnea (OSA) is a prevalent condition that significantly impacts the sleep health and overall well-being of millions of adults worldwide.
- Trial name
- CRESCENDO (NCT06983769)
- Testing
- MAD, CPAP
- Where
- Singapore
- Volunteers
- 260 people
- Sponsor
- National University Hospital, Singapore
Taybi Linder Syndrome, Microcephalic Osteodysplastic Primordial Dwarfism Types I and III
Study of the Pathophysiology of RNU4ATAC and RTTN Associated Syndromes
In the human genome, about 750 genes contain one intron excised by the minor spliceosome. These genes are named U12 genes, and these introns, minor or U12 introns.
- Conditions
- Taybi Linder Syndrome, Microcephalic Osteodysplastic Primordial Dwarfism Types I and III, Roifman Syndrome, Lowry Wood Syndrome
- Trial name
- ATAC (NCT06111950)
- Testing
- Blood samples, Skin biopsies, Fetal samples
- Where
- 6 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Hypothyroidism, Global Developmental Delay
Register for Patients With Thyroid Hormone Resistance.
Thyroid hormones (TH) play a pivotal role in the development and function of the mammalian brain. Patients with impaired thyroid hormone transport into the brain tissue or in the case of defective local thyroid hormone receptor…
- Conditions
- Hypothyroidism, Global Developmental Delay, Intellectual Disability, Dystonia
- Trial name
- DEEPTYPE (NCT06566066)
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Continuous Positive Airway Pressure (CPAP) Assisted Radiotherapy in Breast Cancer
This study is a prospective, non-randomized clinical study aimed at investigating the potential benefits of continuous positive airway pressure (CPAP) support during radiotherapy for breast cancer.
- Trial name
- NCT07373782
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Belgium
- Volunteers
- 53 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obstructive Sleep Apnea (OSA)
IOS Parameters and PAP Titration Pressure in Obstructive Sleep Apnea
This prospective observational study aims to investigate whether impulse oscillometry (IOS)-a non-invasive lung function test-can help predict the specific pressure settings needed for positive airway pressure (PAP) therapy in…
- Trial name
- IOS-PAP (NCT07554430)
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Mustafa Kemal University
Supine Hypertension, Autonomic Failure
Treatment of Supine Hypertension in Autonomic Failure (CPAP)
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT03312556
- Testing
- continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Sleep Apnea
Spanish Registry of Patients With Sleep Apnea and Daytime Sleepiness
Multicenter, observational and prospective study, in which patients referred to the sleep unit with suspected apnea will be recruited obstructive sleep.
- Trial name
- HYPNOSA (NCT06514482)
- Testing
- Diagnosis
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hospital San Pedro de Logroño
Brain Malformation, Neuronal Migration Disorder
Human Epilepsy Genetics--Neuronal Migration Disorders Study
The purpose of this study is to identify genes responsible for epilepsy, brain malformations and disorders of human cognition.
- Conditions
- Brain Malformation, Neuronal Migration Disorder, Cognition Disorder, Epilepsy
- Trial name
- NCT00041600
- Where
- United States
- Volunteers
- 3,500 people
- Sponsor
- Harvard University Faculty of Medicine