Clinical trials: Microcirculation
Microcirculation, Extracorporeal Membrane Oxygenation
Effects of Microcirculation-assisted Adjustment of Blood Flow of VA-ECMO on Prognosis
One of the key factors of survival of patients with extra-corporeal membrane oxygenation (ECMO) life support system is whether the blood flow supplied by ECMO can meet the need of perfusion of each organ.
- Trial name
- NCT03470792
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
Statin and Post-interventional Coronary Microcirculation Dysfunction
The purpose of this study is to evaluate the effect of statin on the coronary microcirculation dysfunction measured after percutaneous coronary intervention.
- Trial name
- NCT01751295
- Testing
- Atorvastatin, pre-treatment 80 mg/day for 4 days before PCI
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Samsung Medical Center
Covid19, Microcirculation
COVID-19 Associated Endothelial Dysfunction Study
SARS-CoV-2 enters human cells through the binding of the spike protein with angiotensin converting enzyme-2 (ACE2), a membrane receptor highly expressed in immune or non-immune cells, and in many organs, including lungs and…
- Trial name
- CAUSED (NCT04773899)
- Testing
- Procedure : Multimodal microvascular assessment at study inclusion
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Angers
Vasodilatation, Oral Soft Tissue Conditions
Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva
The aim of this study is to compare the endothelim-dependent and non-dependent vasodilatation between genders in the human gingiva.
- Trial name
- NCT04918563
- Testing
- Nitroglycerin, Acetylcholine
- Where
- Hungary
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Hypertension
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative…
- Trial name
- NCT01501929
- Testing
- Metoprolol succinate, Nebivolol, Non-invasive measurement of Cardiac Output (CO)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Elective Cardiac Surgery
Microcirculation of the Thenar Eminence
Microcirculatory disturbances following cardiac surgery with cardiopulmonary bypass (CPB) have been thought to be at the origin of organ dysfunction. Though, few studies correlated microvascular alterations with outcome.
- Trial name
- NCT01748266
- Testing
- microcirculatory reactivity
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Septic Shock, Hemodynamic Instability
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand.
- Conditions
- Septic Shock, Hemodynamic Instability, Vasoconstriction
- Trial name
- NCT05225402
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Mitral Valve Insufficiency, Coronary Stenosis
Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair
In the present study, the investigators aim to use the in-vivo Transcatheter Mitral Valve Repair (TMVR) model to determine how Mitral Regurgitation (MR) affects coronary hemodynamics in patients affected with severe MR and…
- Conditions
- Mitral Valve Insufficiency, Coronary Stenosis, Mitral Regurgitation, Coronary Artery Disease
- Trial name
- MitraFLOW (NCT04245956)
- Testing
- Measure of hemodynamic indices in a stenosed coronary artery using a pressure wire
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- University Hospital, Geneva
Continuous Venovenous Hemofiltration
Microcirculation in Continuous Venovenous Hemofiltration Patients on the Intensive Care Unit
In patients where fluid is withdrawn from the bloodstream by Continuous Venovenous Hemofiltration (CVVH), the ultrafiltration rate will be calculated for a zero balance.
- Trial name
- NCT01362088
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Frisius Medisch Centrum
Surgery, Cardiac Event
Effect of Oxiris® Membrane on Microcirculation Following Cardiac Surgery Under Cardiopulmonary Bypass: a Pilot Prospective Monocentric Study (Oxicard Study).
Oxiris membrane is an efficient tool for inflammatory cytokines adsorption. Cardiac surgery is followed by an inflammatory state mimicking sepsis.
- Trial name
- OXICARD (NCT04201119)
- Testing
- Oxiris
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Anesthesia-induced Negative Hemodynamic Effects
Atropine-effect During Propofol/Remifentanil Induction
Remifentanil is a widely used potent intravenous opioid with the advantage of having a short time of action. Compared to other opiates however remifentanil generates more intense hemodynamic side-effects.
- Trial name
- NCT01871922
- Testing
- Atropine
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Vascular Function, Healthy
Effects of Sodium Chloride or Its Substitute Salt Potassium Chloride on Vascular Function
This is a prospective, monocentric, randomized trial to investigate how sodium chloride or its substitute potassium chloride acutely affects vascular function by ingestion via a salted soup.
- Conditions
- Vascular Function, Healthy, Diabetes
- Trial name
- ESCAPE-SALT (NCT05970601)
- Testing
- Soup
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. med. Johannes Stegbauer
Peripheral Arterial Disease, Intermittent Claudication
The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication
The purpose of this study is to determine the effects of metformin on functional capacity (pain-free and maximum walking times) in individuals with peripheral artery disease (PAD)-related intermittent claudication.
- Trial name
- NCT01799057
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Baker Heart and Diabetes Institute
Preeclampsia and Intrauterine Growth Restriction
Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler (MICRODOPPLER PLACENTA)
To identify fetuses small for their gestational-age who have reached their appropriate growth potential from growth-restricted fetuses due to placental insufficiency is uneasy.
- Trial name
- NCT03860103
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Circulatory; Change, Microcirculation
Evaluation of the Circulatory Status of Stomach Tube and Gastrooesophageal Anastomosis
The incidence of anastomotic leaks after gastroesophageal anastomosis after thoracolaparoscopic cancer esophagus surgery is high at the Oslo University Hospital.
- Trial name
- NCT03724162
- Where
- 2 sites in Norway
- Volunteers
- 12 people
- Sponsor
- Oslo University Hospital
Ulcer Foot
Transcutaneous CO₂ Therapy in Recurrent Hard-to-Heal Diabetic Foot Ulcers
Recurrent and hard-to-heal diabetic foot ulcers (DFUs) represent a clinically challenging subgroup with delayed closure and frequent non-response to standard of care (SOC).
- Trial name
- NCT07418073
- Testing
- transcutaneous application of gaseous CO2 on lower part of the body
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Artery Disease, Angina Pectoris
Impact of Coronary Sinus Flow Reducer on Coronary Microcirculation and Myocardial Ischemia
The increasing number of coronary revascularization procedures, coupled with improvements in drug therapy, has significantly extended the lifespan of patients with coronary artery disease (CAD).
- Trial name
- NCT06266065
- Testing
- Coronary Sinus Reducer
- Where
- Croatia
- Volunteers
- 25 people
- Sponsor
- Clinical Hospital Centre Zagreb
Altitude Hypoxia, Perfusion; Complications
The Pre-acclimatization Augmented Extreme Altitude Expedition
The aim of this study is to investigate the effect of pre-acclimatization in a nitrogen tent at home, ventilated with a slightly increased nitrogen percentage, in preparation for an expedition at extreme altitude.
- Trial name
- PRAGMAX (NCT05517044)
- Testing
- Nitrogen tent preacclimatization to high altitude
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Insulin Resistance, Type 2 Diabetes
Microvascular Dysfunction and the Development of Whole-body Insulin Resistance
This study aims to elucidate the role of the microcirculation in the development of whole body insulin resistance. The investigators hypothesize that impaired insulin signaling in the vasculature is an early phenomenon in the…
- Conditions
- Insulin Resistance, Type 2 Diabetes, Obesity
- Trial name
- DESIRE (NCT02628301)
- Testing
- Hypercaloric diet, Normocaloric diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
C.Surgical Procedure, Cardiac
Steroids and Microcirculation In Cardiac Surgery
Cardiac surgery is sometimes associated with organ dysfunction of variable severity (renal insufficiency, cognitive decline, arrhythmias, ARDS).
- Trial name
- SICS (NCT02798068)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Erasme University Hospital