Clinical trials: Microdialysis
Head Trauma
Ketamine and Glutamate After Brain Injury : a Microdialysis Study
The objective of the study is to compare the effects of 48 hours ketamine infusion versus sufentanil infusion on brain glutamate concentrations measured with microdialysis after traumatic brain injury.
- Trial name
- KETABRAIN (NCT02232347)
- Testing
- Ketamine, Sufentanil
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Pierre-Julien CUNGI
Subarachnoid Hemorrhage, Aneurysmal
Multimodality Monitoring Directed Management of Aneurysmal Subarachnoid Haemorrhage
Aneurysmal subarachnoid haemorrhage (aSAH) affects up to 10,000 individuals per year in the UK. It accounts for ~5% of strokes, but is responsible for about 25% quality-adjusted life years (QALYs) lost due to stroke.
- Trial name
- MMMSAH (NCT03010709)
- Volunteers
- 100 people
- Sponsor
- Adel Helmy
Glioma
Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis
Background: Diffuse midline gliomas are the most aggressive brain tumors of childhood and young adults. Most people with these tumors survive less than 2 years.
- Trial name
- NCT05413304
- Testing
- Pre-operative abemaciclib, Device for Cerebral Fluid Dialysate Collection, Ashion Analytics GEM ExTra
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Cardiac Arrest, Neurological Complication
Bedside Monitoring of Cerebral Energy State During the Peri-cardiac Arrest Period
In comatose patients resuscitated from out of hospital cardiac arrest (OHCA), neurological injuries remain the leading cause of death.
- Conditions
- Cardiac Arrest, Neurological Complication, Post-Cardiorespiratory Arrest Coma
- Trial name
- MICA (NCT03095742)
- Testing
- Low MAP, High MAP
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Hypothermia
Impact of Prewarming on Perioperative Body Core Temperature and the Outcomes of Cytoreductive- and Major Open Abdominal Surgery: A Randomised Trial
The primary purpose of this study is to determine whether a prewarming period of at least 30 minutes during induction of general and combined epidural anesthesia reduces the core temperature drop normally occuring in patients…
- Trial name
- PREWARM (NCT02364219)
- Testing
- Prewarming, Microdialysis
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Charite University, Berlin, Germany
Healthy
Microdialysis and Pharmacokinetic Study of TR-701
The purpose of this study is to measure the penetration of TR-700 into subcutaneous adipose tissue and skeletal muscle after a single oral dose of 600 mg TR-701
- Trial name
- NCT00666601
- Testing
- TR-700 (active moiety), TR-701 (pro-drug)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Health Behavior, Healthy
Effects of Fasting in the Bahá'í Faith
The aim of the study is to find out the effects a specific religious fast (i.e. Bahá'í fast) has on certain metabolic parameters, hydration, psyche and circadian clock.
- Trial name
- BF (NCT03443739)
- Testing
- Intermittent Fasting
- Where
- Germany
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany