Clinical trials: Microgravity
Physiological Stress
Operational Performance Effects and Neurophysiology in Partial Gravity
Aim 1: Characterize and quantify changes in operationally-relevant sensorimotor and vestibular performance as a function of gravitational load.
- Trial name
- OPEN-PG (NCT06736652)
- Testing
- Parabolic flight
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Weightlessness
A 5-day Dry Immersion Study on 20 Healthy Male Volunteers
Dry immersion (DI) is a ground-based model of prolonged conditions of simulated microgravity. Dry immersion involves immersing the subject in water covered with an elastic waterproof fabric.
- Trial name
- VIVALDI2 (NCT05493176)
- Testing
- Dry immersion
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Airway Management, Emergency Medicine
Airway Management With Simulated Microgravity Using a Submerged Model
Trained anesthesiologist- or emergency physician-divers will perform an airway management in simulated microgravity on a submerged model.
- Trial name
- AirMicroMod (NCT03848559)
- Testing
- Airway management with a submerged model
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Universitätsklinikum Köln
Nerve Block, Regional Anesthesia
Training Non-Anesthesia Personnel to Perform Nerve Blocks in Microgravity
Space exploration is rapidly progressing with multiple upcoming missions planned to the moon and International Space Station, and projected missions to Mars in the early 2030s.
- Conditions
- Nerve Block, Regional Anesthesia, Microgravity, Space Analogue
- Trial name
- Block-aid (NCT07849049)
- Testing
- Simulated microgravity, Normal earth gravity
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Simulated Microgravity by Head Down Tilt Bedrest, Weightlessness
A 60 Days Head Down Tilt Bedrest With Artificial Gravity and Cycling Exercise on 24 Healthy Male (BRACE)
The objective of this study is to investigate whether a cycling exercise coupled with artificial gravity via a short-arm human centrifuge helps to prevent and / or reduce the deleterious effects induced by 60 days of…
- Trial name
- BRACE (NCT06544213)
- Testing
- Control Group, Countermeasure Supine Bike, Countermeasure AG-Bike
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Weightlessness
Space Flight Simulation to Study Effects of Micro-gravity Through Bed Rest
Space flight simulation study to study effects of microgravity through bedrest coupled with flight exercise counter-measures.
- Trial name
- FAP (NCT00891449)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Weightlessness, Cerebral Blood Flow
Cerebral Blood Flow Distribution During Parabolic Flight-induced Microgravity
When astronauts return from space flight, they manifest a set of symptoms, the most striking of which is orthostatic intolerance, that is, the inability to stay upright.
- Trial name
- GraCer (NCT03986788)
- Testing
- Weightlessness
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Weightlessness, Weightlessness; Adverse Effect
Integrative Study of Physiological Changes Induced by a 5-Day Dry Immersion on 20 Healthy Female Volunteers (DI5-Women)
Dry immersion (DI) is a ground-based model of prolonged conditions of simulated microgravity. Dry immersion involves immersing the subject in water covered with an elastic waterproof fabric.
- Trial name
- VivalDI (NCT05043974)
- Testing
- Dry immersion
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Decompression Sickness
NASA Prebreathe Study
This study will validate the experimental method and chamber facility at the Duke Center for Hyperbaric Medicine \& Environmental Physiology and test team capabilities to support NASA decompression sickness (DCS) studies.
- Trial name
- NASA Prebreath (NCT06740305)
- Testing
- Altitude, 100% Oxygen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy
3D Ballistocardiography in Microgravity
3-D Ballistocardiography (BCG) recording was performed in microgravity during the Spacelab D2 missions on a single astronaut. The results from this experiment have been published in the literature: the influence of respiration…
- Trial name
- B3D (NCT02517112)
- Testing
- Parabolic flight, Cardiovascular parameters measurements, 3D-BCG sensor
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Semen Quality
The Effects of Microgravity on Human Sperm
It has been described that microgravity affects cellular and molecular structures. Cell membrane, cytoskeleton, cytoplasm and nucleus have been found to be sensible to gravitational changes.
- Trial name
- NCT03760783
- Testing
- Parabolic flight
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus