Clinical trials: Microscopic Study
Infertility
Atrificial Shrinkage of Blastocyst Before In Vitro Fertilization
Vitrification is a modern cryopreservation technique based on sudden cooling of reproductive cells to a temperature of -196 ° C in seconds that produces glass-like solidification of a solution without crystallization, but by…
- Trial name
- NCT04125017
- Testing
- ICSI with laser pulse, ICSI with micro needle technique
- Where
- Egypt
- Volunteers
- 409 people
- Sponsor
- Aljazeera Hospital
Breast Cancer, Breast Adenocarcinoma
Rebastinib Plus Antitubulin Therapy With Paclitaxel or Eribulin in Metastatic Breast Cancer
The purpose of this study is to determine the safety and tolerability of rebastinib when combined with antitubulin therapy with paclitaxel or eribulin in patients with advanced breast cancer.
- Conditions
- Breast Cancer, Breast Adenocarcinoma, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, Recurrent Breast Carcinoma
- Trial name
- NCT02824575
- Testing
- Rebastinib, Paclitaxel, Eribulin Mesylate
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Montefiore Medical Center
Fat Excretion, Energy Excretion
Calcium Intake and Fat Excretion
The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.
- Trial name
- KIFU/B266 (NCT01542164)
- Where
- Denmark
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Intraductal Carcinoma and Lobular Carcinoma in Situ
Management of Ductal Carcinoma in Situ or Pure Micro-invasive Extended Breast
When invasive components are discovered at mastectomy for vacuum-assisted biopsy (VAB)-diagnosed ductal carcinoma in situ (DCIS), the only option available is axillary lymph node dissection (ALND).
- Trial name
- CINNAMOME (NCT01841749)
- Testing
- sentinel node biopsy and mastectomy
- Where
- France
- Volunteers
- 228 people
- Sponsor
- Institut Bergonié
HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma
CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial
This study is focused on treatment of anal high-grade squamous intraepithelial lesions (HSIL) in persons with HIV (PWH), with the ultimate goal of applying the approach toward prevention of anal cancer in this population
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma, Anal HSIL
- Trial name
- NCT06949800
- Testing
- EXE-346 Probiotic, Usual Care High Resolution Anoscopy (HRA)
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Cholecystitis; Gallstone
Robotic Cholecystectomy Using the Chinese Micro Hand S Robot: A Controlled, Randomized, Prospective Clinical Study
A single-blinded, prospective randomized parallel controlled clinical trial was designed and conducted from December 2019 to November 2020.
- Trial name
- NCT04803487
- Testing
- robot-assisted cholecystectomy
- Where
- China
- Volunteers
- 82 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Depression, Mood
2018 Intern Health Study Micro-randomized Trial
The aim of this trial is to evaluate the efficacy of an intervention (delivered through a smartphone) for improving the mood, physical activity, and sleep of medical interns.
- Conditions
- Depression, Mood, Sleep, Physical Activity
- Trial name
- IHS (NCT03972293)
- Testing
- Intern Health Study behavioral change mobile notification, Intern Health Study mobile app
- Where
- United States
- Volunteers
- 2,134 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cervical Intraepithelial Neoplasia, Uterine Cervical Dysplasia
A Two-Stage Phase 2 Study Of A-007 Topical Gel in High-Grade Squamous Intraepithelial Lesions (HSIL)
A-007 is an investigational therapy which may be effective in the treatment of pre-cancerous cervical dysplasia (abnormal cell growth).
- Trial name
- TG-003 (NCT00596258)
- Testing
- A-007
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- Tigris Pharmaceuticals
Cancer Head Neck
Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer
Multi-centre retrospective observational cohort study with optional exploratory radiomic study (international) and prospective molecular analysis studies (UK only).
- Trial name
- SCORE (NCT05933889)
- Testing
- Molecular Analysis, Radiomic/ Morphological analysis
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Royal Marsden NHS Foundation Trust
COPD, COPD Exacerbation
mRNA and miRNA Airway Inflammatory Markers
This study investigates cytokine Messenger (mRNA) and microRNA (miRNA) level expression of interleukin (IL) -6, IL-8, IL-17, tumor necrosis factor (TNF)-alpha, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory…
- Trial name
- NCT03924843
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- University Medical Center Groningen
ASC-US, LSIL
Study of Treatment for HPV16+ ASC-US or LSIL
Phase I clinical trial to assess safety of pNGVL4aCRTE6E7L2 DNA and TA-CIN protein vaccinations, and to seek the appropriate dose of the pNGVL4aCRTE6E7L2 DNA vaccine
- Trial name
- PVX-6 (NCT03913117)
- Testing
- pNGVL4aCRTE6E7L2, TA-CIN
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
LSIL, Low-Grade Squamous Intraepithelial Lesions
Observational vs. Ablative Treatment for Low-grade Squamous Intraepithelial Lesions.
To evaluate the rate of regression and progression of low-grade squamous intraepithelial lesion comparing expectant vs. ablative treatment.
- Trial name
- NCT02331550
- Testing
- Ablative treatment, Expectant management
- Where
- Panama
- Volunteers
- 250 people
- Sponsor
- Saint Thomas Hospital, Panama
Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer
Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgery
This phase II trial studies how well giving combination chemotherapy and filgrastim together before surgery works in treating patients with human epidermal growth receptor 2 (HER2)-positive breast cancer that can be removed by…
- Conditions
- Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer, HER2-positive Breast Cancer, Progesterone Receptor-negative Breast Cancer
- Trial name
- NCT00194779
- Testing
- doxorubicin hydrochloride, cyclophosphamide, paclitaxel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ
Hair Regrowth Following Partial Thickness Removal of SSCIS
Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp.
- Conditions
- Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ, Alopecia
- Trial name
- NCT07809191
- Testing
- Partial Thickness Excision
- Volunteers
- 15 people
- Sponsor
- The Cooper Health System
Chronic Total Occlusion of Coronary Artery
A Prospective, First in Man Study to Evaluate the Safety and Performance of the NovaCross™ Micro-catheter
This is a prospective, non-randomized, first-in-man investigational study, to assess the safety and technical feasibility, deployment and withdrawal characteristics of the NovaCross™ micro-catheter during an interventional…
- Trial name
- NCT01978860
- Testing
- NovaCross, CTO
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Chanan Schneider
Metabolic Syndrome, Endothelial Dysfunction
Effect of Eplerenone on Endothelial Function in Metabolic Syndrome
Patients with the metabolic syndrome (MetSyn) are at increased risk for cardiovascular mortality and morbidity.This increased cardiovascular risk is attributed to metabolic dysregulations like impaired glucose tolerance or…
- Trial name
- MetSyn (NCT01319344)
- Testing
- Eplerenone
- Where
- 2 sites in Germany
- Volunteers
- 42 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Wrinkle, Rosacea
Evaluation of Cutera Excel V™ Laser With Green Genesis and Micro-Lens Array (MLA)Attachment
Evaluate the Cutera excel V™ Laser with Green Genesis and a Micro-Lens Array (MLA) Attachment
- Conditions
- Wrinkle, Rosacea, Scarring
- Trial name
- NCT03424304
- Testing
- Excel V™ Laser With Green Genesis
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
ICU Acquired Weakness, Muscle Atrophy
Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )
Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay.
- Conditions
- ICU Acquired Weakness, Muscle Atrophy, Energy Malnutrition Protein, Quality of Life
- Trial name
- NCT05919940
- Testing
- Dietary Supplement: additional substitution of protein, Neuromuscular electrical stimulation, Early Mobilization
- Where
- 4 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Triple Negative Breast Cancer
Modifications of Immune Microenvironment Induced by Neoadjuvant Chemotherapy in Triple-negative BC
The prescription of neoadjuvant chemotherapy becomes a standard in women with HER2-positive or triple-negative breast cancer and allows a complete histological response (pCR) which represents a prognostic factor for survival. .
- Trial name
- MIMOSA (NCT04368468)
- Testing
- biomarker evolution
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut Claudius Regaud
Colo-rectal Cancer
PTC Drug Sensitivity Detection to Guide Postoperative Adjuvant of Colorectal Cancer
The research objectives is to compare vitro 3D drug sensitivity test results of micro tumor (PTC) with the clinical outcomes of patients, evaluate the consistency between the test results of the technology platform and the…
- Trial name
- NCT05978349
- Testing
- adjuvant therapy based on 3D drug sensitivity test results of micro tumor (PTC) in vitro
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital