Clinical trials: Microvascular Angina, open to volunteers
Hypertension, Blood Pressure Monitoring, Home
Home Blood Pressure Variability and Its Link to Arteriosclerosis and Metabolic Dysfunction in Hypertensive Patients
This observational study investigates the correlation between home blood pressure variability (BPV) and arteriosclerosis, alongside metabolic indicators, in hypertensive patients over a three-year period.
- Conditions
- Hypertension, Blood Pressure Monitoring, Home, Arteriosclerosis, Metabolic Syndrome X
- Trial name
- NCT06394934
- Testing
- Healthscan App
- Where
- 2 sites in South Korea
- Volunteers
- 4,188 people
- Sponsor
- Korea University Anam Hospital
Angina, Non-obstructive Coronary Artery Disease
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million people in the United States alone, and 112 million people globally.
- Trial name
- NCT05634031
- Testing
- PET imaging, Coronary CT angiogram, Functional Angiography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
ANOCA, ANOCA - Angina With Non-obstructive Coronary Arteries
Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic
Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of…
- Conditions
- ANOCA, ANOCA - Angina With Non-obstructive Coronary Arteries, MINOCA, Microvascular Dysfunction
- Trial name
- CoroPhys-CZ (NCT07103317)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Microvascular Angina, Angina, Stable
iCorMicA - Stratified Medicine in Angina
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry.
- Conditions
- Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
- Trial name
- iCorMicA (NCT04674449)
- Testing
- Disclosure of IDP results, IDP performed but results not disclosed
- Where
- 39 sites in Ireland, Netherlands and 2 more
- Volunteers
- 1,500 people
- Sponsor
- NHS Greater Glasgow and Clyde
Coronary Microvascular Disease
An Observational Study of Coronary Microvascular Disease of China
Non-obstructive coronary heart disease refers to patients with angina pectoris without significant narrowing of the epicardial vessels.
- Trial name
- CCMD (NCT06676137)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Heart Failure, Microvascular Angina
Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology
This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with…
- Conditions
- Heart Failure, Microvascular Angina, Non-ischemic Cardiomyopathy
- Trial name
- HFrEF-CMD (NCT06243653)
- Testing
- CMD test
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Coronary Microvascular Disease, CMD
Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary…
- Trial name
- ExINOCA (NCT06529848)
- Testing
- Exercise training
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Bispebjerg Hospital
Cancer, Chemotherapeutic Toxicity
Serial PET MPI in Patients Undergoing Cancer Treatment
This study aims to evaluate the effects of cardiotoxic cancer therapies on myocardial blood flow (MBF) and perfusion in a prospective sample of VA patients.
- Conditions
- Cancer, Chemotherapeutic Toxicity, Coronary Artery Disease, Coronary Microvascular Disease
- Trial name
- NCT05913999
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Microvascular Angina
Microvascular Angina Intervention With Compound Danshen Dripping Pill (MAIDS)
Coronary microvascular disease (MVD) refers to exertional angina or myocardial ischemia caused by abnormal structure and/or function of precoronary arterioles and arterioles under the action of various pathogenic factors.
- Trial name
- MAIDS (NCT06092736)
- Testing
- Compound Danshen Dropping Pills
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Microvascular Disease
A Clinical Study of Fundus OCTA for the Identification of CMD
Coronary microvascular dysfunction (CMD) carries an increased risk of adverse cardiovascular clinical outcomes. The association between fundus microcirculation changes and coronary microcirculation is not well understood.
- Trial name
- NCT05743140
- Testing
- CaIMR
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University First Hospital
Hypertrophic, Ischemic
Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry
Long-term prognostic value of macrovascular and microvascular coronary artery stenoses in each type of cardiomyopathy.
- Conditions
- Hypertrophic, Ischemic, Restrictive Cardiomyopathy, Dilated Cardiomyopathies
- Trial name
- 3CRegistry (NCT03479580)
- Testing
- Patients with a cardiomyopathy
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Grenoble
Coronary Microvascular Angina, Macitentan
Evaluation of the Efficacy of MACitentan in the Treatment of CoronaryMICrovascular Angina (MACMIC)
Coronary microvascular angina (MVA) significantly reduces quality of life and increases the risk of heart problems in patients with angina. Unfortunately, there are no effective treatments available yet.
- Trial name
- NCT06811831
- Testing
- Macitentan 10 mg tablet, once daily.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Friendship Hospital
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Invasive Evaluation and Phenotype-Guided Treatment of ANOCA in Women
This prospective single-center interventional study will include women with angina and non-obstructive coronary arteries. Participants will undergo a standardized invasive coronary assessment combining coronary physiology…
- Conditions
- ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD), Vasospastic Angina
- Trial name
- ANOCA-UY (NCT07593157)
- Testing
- Invasive Coronary Functional and Morphological Assessment, Pharmacological treatment will be individualized according to the invasive coronary phenotype identified. Treatment may include antianginal therapy, vasodilator therapy, endothelial function-targeted
- Where
- Uruguay
- Volunteers
- 50 people
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Coronary Arterial Disease (CAD), Angina (Stable)
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
- Conditions
- Coronary Arterial Disease (CAD), Angina (Stable), Microvascular Circulation
- Trial name
- BEACON (NCT06864234)
- Testing
- Saline (NaCl), Metoprolol Tartrate
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Coronary Microvascular Disease, Coronary Vasospasm
Multicenter Registry on Microvascular Dysfunction - Searching a New Ach Spasm Definition
The MICRO-SNAPE registry will collect data from patients undergoing investigation of microvascular dysfunction and coronary spasm in Europe and North America.
- Trial name
- MICRO-SNAPE (NCT06125392)
- Testing
- Coronary physiology assessment
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Angina (Stable), Ischemic Heart Disease (IHD)
Angina After PCI: a Systems Medicine Study
Angina may persist or recur in patients treated by coronary angioplasty. The angioplasty involves a balloon treatment to open a blocked heart blood vessel and usually a stent (thin metal tube) is placed.
- Trial name
- CorMicA-PCI (NCT06854302)
- Testing
- Cardiovascular magnetic resonance imaging, Coronary physiology
- Where
- 4 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- NHS National Waiting Times Centre Board
Microvascular Angina
The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients With Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI).
Microvascular angina is thought to affect around 112 million patients worldwide. However, this figure is underestimated due to the difficulty of making the diagnosis.
- Trial name
- EYE-NOCA (NCT06692751)
- Testing
- Blood sampling, Ophthalmological examination, angina severity questionnaire
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris
A Multi-center, Real-World Clinical Trial of caIMR on Two Specific Kinds of Patients.
The coronary angiography-derived index of microcirculatory resistance (caIMR) can be used to provide a binary assessment whether patients（with stable angina, unstable angina, suspected myocardial ischemia, or coronary artery…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris, Unstable Angina Pectoris, Myocardial Ischemia, Angina Pectoris
- Trial name
- FlashV (NCT06945094)
- Testing
- caIMR
- Volunteers
- 508 people
- Sponsor
- Ge Junbo
Microvascular Coronary Dysfunction, Microvascular Angina
Microvascular Coronary Rehabilitation For Improving Treatment - Feasibility Study
The goal of this clinical trial is to assess the feasibility of undertaking a randomized controlled trial assessing the impact of a personalised, intense cardiac rehabilitation programme involving high intensity interval exercise…
- Conditions
- Microvascular Coronary Dysfunction, Microvascular Angina, Coronary Microvascular Dysfunction (CMD)
- Trial name
- MICROFIT (NCT06681896)
- Testing
- MICROFIT - personalised high intensity interval training exercise rehabilitation and dietary advice
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht