Clinical trials: Microvascular Circulation
Acute Ischemic Stroke, Reperfusion
Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Reperfusion, Large Vessel Occlusion
- Trial name
- CRYSTAL (NCT05836766)
- Testing
- Y-6 sublingual tablets
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Microcirculation in Pregnancy
Sublingual Microcirculation Change During Pregnancy and Postpartum Period
Sublingual microcirculation change in pregnant women with or without high risk pregnancy factors during pregnancy and postpartum period.
- Trial name
- Cytocam-OBS (NCT03476096)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Critical Illness, Healthy
Assessment of the Repeatability of Sublingual Microcirculation Function Measurements in Healthy Volunteers and Critically Ill Patients
The assessment of microcirculatory function plays a pivotal role in perioperative medicine and intensive care. One promising method for evaluating microcirculatory function is the microscopic analysis of the oral mucosal…
- Trial name
- NCT07397208
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Raynaud's Phenomenon
"As Required" Oral Sildenafil in Raynaud's Phenomenon
The purpose of this study is to determine whether "on-demand" sildenafil is effective in the treatment of Raynaud's phenomenon.
- Trial name
- PROFIL (NCT02050360)
- Testing
- Sildenafil 40 mg, Sildenafil 80 mg
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Grenoble
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
Spinal Anesthesia
Changes in the Microvascular Reactivity on Leg During Spinal Anesthesia
Anesthesia alters microcirculation and tissue oxygen saturation (StO2). We sought to examine changes in StO2 using near-infrared spectroscopy and a vascular occlusion test (VOT) during spinal anesthesia.
- Trial name
- NCT04806997
- Testing
- Vascular occlusion test
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Pusan National University Hospital
Diabetes Mellitus
Efficacy of Pioglitazone on Microcirculation in Type 2 Diabetes Patients Treated With Insulin
The purpose of this study is to measure microcirculation in type 2 diabetes patients with peripheral edema who are taking pioglitazone, once daily (QD).
- Trial name
- NCT00676260
- Testing
- Pioglitazone
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Takeda
Burn Injury, Acute Wound
Cutaneous Microcirculation After Plasma Therapy
In plastic and reconstructive surgery, treatment strategies of second-degree burns, superficial wounds, burn scars, flaps and chronic wounds aim at reducing infection and improving microcirculation.
- Conditions
- Burn Injury, Acute Wound, Chronic Wound, Burn Scar
- Trial name
- NCT02417818
- Testing
- Plasma Therapy (PlasmaDerm), Repetitive Plasma Therapy (repetitive PlasmaDerm)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- University Hospital Schleswig-Holstein
Surgery, Hypovolemic Shock
Kinetics of the Sublingual Microcirculation During Fluid Bolus
Fluid therapy is one of the cornerstones of the treatment of organ failure. The investigators assume that fluid bolus will increase the delivery of oxygen to the cells and resolve the shock.
- Trial name
- NCT02675725
- Testing
- Measurement of sublingual microcirculation with Cytocam-IDF camera
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Frisius Medisch Centrum
Frozen Shoulder
Outcomes of Frozen Shoulder Treated With Small Needle-Knife Through Microcirculation and Pulse Analysis.
The aim is to investigate whether adding small needle-knife therapy to standard Western medicine enhances the treatment of frozen shoulder by evaluating its impact on microcirculation and meridian unblocking.
- Trial name
- NCT06139276
- Testing
- Small Needle-Knife, Standard treatment
- Volunteers
- 120 people
- Sponsor
- Taipei City Hospital
Sarcopenia in Elderly, Muscle Atrophy
Effects of Cyclical Blood Flow Restriction Exercise on Muscle Hypertrophy and Capillaries in Older Adults
The purpose of this study was to learn if low-load resistance exercise combined with cyclical blood flow restriction (BFR) could improve small blood vessel structure and muscle size in older adults.
- Conditions
- Sarcopenia in Elderly, Muscle Atrophy, Aging
- Trial name
- NCT07689487
- Testing
- Blood Flow Restriction (BFR), Conventional Low-Load Resistance Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Myocardial Ischemia
Peripheral Endothelial Function and Coronary Status in Asymptomatic Diabetic Patients
Silent myocardial ischemia is usual in type 2 diabetic patients and associated with coronary stenoses and endothelial dysfunction or both.
- Trial name
- PEFDIA (NCT00685984)
- Where
- France
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure
Hyperoxia, Erythropoiesis and Microcirculation in Critically Ill Patient
Prospective observational study in 40 adult critically ill patients. Patients were eligible if they were mechanically ventilated with an FiO2 ≤0.5 and PaO2/FiO2 ≥200 mmHg and hemodynamically stable with a hemoglobin ≥9 g/dL, no…
- Trial name
- NCT02481843
- Testing
- 2 hours of hyperoxia (FiO2 = 1)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Politecnica delle Marche
Proximal Humeral Fractures
Examination of Microcirculation of the Caput Humeri After Proximal Humerus Fracture
This study examines the microcirculation of the caput humeri after proximal humeral fracturation using O2C light probes. During the operation the blood circulation is measured at four points (tuberculum majus, tuberculum minus…
- Trial name
- NCT01737385
- Testing
- Measurement with O2C
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- RWTH Aachen University
Transthoracic Esophagectomy
Observational Study of Sublingual Microcirculatory Blood Flow Characteristics in Patients Undergoing Transthoracic Esophagectomy
Microcirculatory alterations occur in critically ill patients and those undergoing major surgeries. The severity of perioperative microvascular alterations appear to be related to the severity of organ dysfunction after surgery.
- Trial name
- NCT02263664
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Virginia
Traumatic Haemorrhagic Shock
An Observational Pilot Study of the Effects of Traumatic Haemorrhagic Shock and Resuscitation on the Microcirculation
Haemorrhage following major trauma is an important preventable cause of death. Those patients who survive may have a prolonged period of debility caused by failure of key body organs.
- Trial name
- MICROSHOCK (NCT02111109)
- Testing
- Side Stream Dark Field Microscopy
- Where
- 3 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- King's College Hospital NHS Trust
Shock, Sepsis
Bedside Visual Analysis of Sublingual Microcirculation in Shock Patients
In shock patients, fluid resuscitation, infusion of vasopressors and transfusion are guided on hemodynamic macrovascular parameters.
- Conditions
- Shock, Sepsis, Hemorrhagic Shock
- Trial name
- MICROEYE (NCT03406598)
- Testing
- Patients in shock
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Microcirculation Detection in Diabetic Patients
The Predictive Value of Sidestream Dark Field Imaging in Diabetic Nephropathy
Diabetic microangiopathy refers to the pathological changes of arterioles, capillaries and venules in diabetic patients. Due to the impacts including glycol-metabolism disorder, disturbance of lipid metabolism, cytokine…
- Trial name
- NCT04403945
- Testing
- Sidestream dark field(SDF) imagining
- Where
- China
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Microcirculatory Status, Spectroscopic Analysis
Near-Infrared Spectroscopy Measurements in Chronic Obstructive Pulmonary Disease
Participants were selected based on three groups: healthy, chronic obstructive pulmonary disease, and chronic renal disease. NIRS was used to measure tissue oxygenation on the thenar region of the right hand.
- Conditions
- Microcirculatory Status, Spectroscopic Analysis, COPD, Renal Failure
- Trial name
- NIRS (NCT06976762)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Microcirculation, Thermoregulation
Impact of Active Thermoregulation on the Microcirculation of Free Flaps
This study evaluates the impact of active thermoregulation on free flap microcirculation following free flap transfer. Thermoregulation is performed by passive warming, active warming (water circulation based device) and active…
- Conditions
- Microcirculation, Thermoregulation, Free Flap
- Trial name
- NCT02466594
- Testing
- Hilotherm Clinic®
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ulf Dornseifer, MD