Clinical trials: Microvascular Circulation
Critical Illness
Sublingual Microcirculation Monitoring in ICU
Prospective observational study designed to implement a daily monitoring of microcirculation and tissue oxygenation in all critically ill patients admitted to the ICU in the period of nine months, in order to assess the…
- Trial name
- MICRODAIMON (NCT02649088)
- Testing
- Microscan, NIRS from Hutchinson
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Università Politecnica delle Marche
Sepsis
Temperature Gradients for Sepsis Severity and Fluid Resuscitation
The assessment and treatment of Septic Shock (SS) is a thorny issue in current care. Fluid resuscitation is one of the key measures for SS treatment.
- Trial name
- sepsis (NCT04068298)
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Sepsis
Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis
Fluid resuscitation of severe sepsis may consist of natural or artificial colloids or crystalloids. There is no evidence-based support for one type of fluid over another.
- Trial name
- NCT00799916
- Testing
- Resuscitation (Voluven), Resuscitation (Saline)
- Where
- 3 sites in Argentina
- Volunteers
- 30 people
- Sponsor
- Universidad Nacional de La Plata
Blood Loss, Surgical, Fluid Retention
Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement
Fluid intravascular replacement is usually performed with either balanced crystalloids or iso-oncotic colloids, (synthetic colloids, plasma and 5% albumin).
- Trial name
- VASCALB (NCT05391607)
- Testing
- Hyperoncotic Albumin 20%, Isooncotic Albumin 5%, Ringer's Lactate Crystalloid Solutions (control group)
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease (CAD)
Comparison of Orbital Versus Rotational Atherectomy Effects On Coronary Microcirculation in PCI
The investigators hypothesize that the orbital atherectomy system (OAS), a newer generation atherectomy device, reduces the incidence of microcirculatory compromise as compared to older generation rotational atherectomy (RA) due…
- Trial name
- ORACLE (NCT03021577)
- Testing
- Orbital Atherectomy System (OAS), Rotablator Rotational Atherectomy System, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Columbia University
Type 2 Diabetes Mellitus, Peripheral Microvascular Symptoms
The Effect of Prostaglandin I2 on the Endothelial Cell Function Disorder in Type 2 Diabetes Mellitus Patients
This study attempts to examine the effect of oral prostaglandin I2 (Beraprost Na), administered for eight weeks, on the endothelial cell functional disorder among asymptomatic high risk diabetes mellitus patients.
- Trial name
- NCT01061060
- Testing
- Prostaglandin I2
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Yonsei University
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Flap Monitoring, Inflammation
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient
This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients undergoing elective…
- Conditions
- Flap Monitoring, Inflammation, Thrombosis, Oxidative Stress
- Trial name
- DEXFLAP (NCT06993740)
- Testing
- NaCl 0,9%, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Dharmais National Cancer Center Hospital
Myocardial Blood Flow Reserve, Mechanical Dyssynchrony
Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT
The project is aimed at studying the feasibility of mechanical dyssynchrony of the left ventricle of the heart, determined by SPECT (gated MPI), as well as its stress-induced dynamics, in the evaluation of patients with coronary…
- Conditions
- Myocardial Blood Flow Reserve, Mechanical Dyssynchrony, Coronary Arterial Disease (CAD)
- Trial name
- MD&MD (NCT06969547)
- Testing
- dynamic SPECT (two-day rest/stress protocol), gated myocardial perfusion imaging, blood sampling
- Where
- Russia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Septic Shock
Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock
This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.
- Trial name
- NCT03821714
- Testing
- Glucocorticoid combination therapy, Glucocorticoid
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Southeast University, China
Acute Pancreatitis
Epidural Anesthesia in Acute Pancreatitis
Acute pancreatitis is a common urgency with a mortality rate of up to 30% , decreased blood flow in the pancreatic microcirculation. It seems to be the main cause of the pathophysiology of acute pancreatitis.
- Trial name
- NCT02617199
- Testing
- Epidural anesthesia, intravenous analgesia
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval