Clinical trials: Microvascular Coronary Dysfunction
Coronary Microvascular Dysfunction, Ischemic Non-Obstructive Coronary Artery Disease
MCG as a Noninvasive Diagnostic Strategy for Suspected Coronary Microvascular Dysfunction
According to the Women's Ischemic Syndrome Evaluation database, there are approximately 3 to 4 million women and men who present with signs and symptoms that are suggestive of myocardial ischemia, however they have no obstructive…
- Trial name
- MICRO (NCT05150054)
- Testing
- CardioFlux
- Where
- 4 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Genetesis Inc.
Coronary Artery Disease, Coronary Microvascular Dysfunction
Multimodal Epicardial and Endocardial COronary PHYsiological Evaluation in Pathological Situations (PHYCO)
When performing coronary angiography in a stable situation, the identification of an intermediate coronary lesion (between 50 and 70%) is common, and requires additional functional evaluation.
- Trial name
- PHYCO (NCT06008041)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Brest
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
CMR in T2DM: The NSR Cohort
This study aims to investigate the myocardial phenotype of patients with type 2 diabetes. From 2016-2019 the investigators recruited a cohort of 296 subjects with type 2 diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies, Cardiovascular Magnetic Resonance Imaging, Coronary Microvascular Dysfunction
- Trial name
- NCT05915260
- Testing
- All subjects will undergo cardiac magnetic resonance imaging with gadolinium contrast and with adenosine myocardial perfusion
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Slagelse Hospital
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Absolute Flow for Ischemia With No Obstructive Coronary Arteries
The main objective is to prospectively validate the capacity of continuous thermodilution coronary flow reserve (CFRflow) as a predictor of the presence of angina measured by SAQ7 in patients with INOCA at 3 months.
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Angina, Stable
- Trial name
- AF-INOCA (NCT05825339)
- Testing
- Coronary Flow Reserve
- Where
- 6 sites in Spain
- Volunteers
- 121 people
- Sponsor
- Spanish Society of Cardiology
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Simultaneous Assessment of Coronary Microvascular Dysfunction and Ischemia With Non-obstructed Coronary Arteries With Intracoronary Electrocardiogram and Intracoronary Doppler
Coronary Microvascular Dysfunction has been consistently shown to play a considerable role in pathophysiology of Ischaemia with non-obstructed coronary arteries (INOCA).
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Non-Obstructive Coronary Atherosclerosis, Microvascular Angina
- Trial name
- NCT05471739
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Istanbul University
Coronary Microvascular Dysfunction
A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Online Coronary Angiography-Derived Index of Microcirculatory Resistance (caIMR)
More than 50% of patients with stable or unstable angina pectoris have no obstructive coronary arteries by angiographic visual estimation, in which coronary microvascular dysfunction (CMD) is one of the causes of myocardial…
- Trial name
- Flash III (NCT05009667)
- Testing
- Angiography-derived Index of Microcirculatory Resistance, Pressure wire-based Index of Microcirculatory Resistance
- Where
- 3 sites in China
- Volunteers
- 116 people
- Sponsor
- Ge Junbo
Coronary Microvascular Dysfunction, Microvascular Angina
Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease
EXAMINE-CAD-DZHK22 is a prospective, randomized, double-blind, placebo-controlled, crossover trial investigating the efficacy of beta blocker (bisoprolol) and calcium channel blocker (diltiazem) therapy in symptomatic patients…
- Conditions
- Coronary Microvascular Dysfunction, Microvascular Angina, Vasospasm, Coronary, Vasospastic Angina
- Trial name
- EXAMINE-CAD (NCT05294887)
- Testing
- Bisoprolol, Diltiazem
- Where
- 15 sites in Germany, Switzerland
- Volunteers
- 132 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease
Microvascular Coronary Resistance and Absolute Coronary FLOW in Patients With Percutaneous Intervention of a Chronic Total Occlusion
It is an observational study which objective is to analyze, through a series of invasive parameters, the state of the coronary microvasculature immediately after the successful percutaneous coronary intervention of a chronic…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease, Coronary; Ischemic, Coronary Microvascular Dysfunction
- Trial name
- FLOW-CTO (NCT05197361)
- Testing
- Invasive coronary physiology
- Where
- 4 sites in Spain
- Volunteers
- 34 people
- Sponsor
- Parc de Salut Mar
Coronary Microvascular Dysfunction, Obstructive Coronary Heart Disease
The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease
The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to…
- Trial name
- NCT04959357
- Testing
- Two dimensional speckle tracking imaging
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Peking University Third Hospital
Coronary Microvascular Dysfunction, Myocardial Ischemia
Diagnostic and Prognostic Value of Angiography-derived IMR
The importance of the microvasculature in determining clinical outcomes has been highlighted in patients with coronary artery disease (CAD).
- Trial name
- CHART-MiCro (NCT04825028)
- Testing
- Angiography-drived Index of Microcirculatory Resistance
- Where
- China
- Volunteers
- 271 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Microvascular Dysfunction
Safety and Potential Bioactivity of CLBS16 in Patients With Coronary Microvascular Dysfunction and Without Obstructive Coronary Artery Disease
This clinical trial will explore the safety and effect of GCSF-mobilized autologous ex vivo selected CD34 cells for the treatment of CMD in adults currently experiencing angina and with no obstructive coronary artery disease.
- Trial name
- NCT03508609
- Testing
- CLBS16
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Lisata Therapeutics, Inc.
Endothelial Dysfunction, Coronary Microvascular Disease
Functional Assessment of the Infart-related Artery With Bioactive and Polymer-free Coronary Stents (The FUNCOMBO Trial)
A total of 50 patients with ST-elevation myocardial infarction (STEMI) undergoing primary-percutaneous coronary intervention (PPCI) will be randomized to two different coronary stents: BIOFREEDOM vs. COMBO stent.
- Conditions
- Endothelial Dysfunction, Coronary Microvascular Disease, Myocardial Infarction
- Trial name
- FUNCOMBO (NCT04202172)
- Testing
- Stent implantation in the infart-related artery in patients with ST elevation myocardial infarction
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Ischemic Heart Disease, Microvascular Coronary Artery Disease
The Cerebral-Coronary Connection (C3) Study
This is a prospective cohort blinded study with the aim to investigate the prevalence and clinical impact of coronary microcirculatory dysfunction (CMD) in patients with ischemic heart disease, and its association with cerebral…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Depression, Endothelial Dysfunction
- Trial name
- C3 (NCT04131075)
- Testing
- Coronary Angiography and Multimodal Coronary Physiology Study (FFR, CFR, HMR)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Salud Carlos III
Microvascular Coronary Dysfunction (MCD)
Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia
This research study is designed to test the use of ranolazine in patients with angina (chest discomfort due to reduced blood supply to the heart) due to microvascular coronary dysfunction (MCD; abnormalities in the small blood…
- Trial name
- RWISE (NCT01342029)
- Testing
- Ranolazine
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Cedars-Sinai Medical Center
Microvascular Coronary Dysfunction
Benefits of Exercise Training in Women With Ischemic Syndrome
Angina in the absence of obstructive coronary artery disease is highly prevalent in women, and leads to increased risk for major cardiovascular events, including myocardial infarction, stroke, and heart failure.
- Trial name
- NCT02374086
- Testing
- Exercise training
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Coronary Microvascular Dysfunction
Effect of Intact GLP-1 (7-36) and GLP-1 Metabolite (9-36) on Coronary and Peripheral Vascular Function in Adults
GLP-1 is an agent for treatment of type 2 diabetes and may have protective effects on the cardiovascular system. The mechanism is complex and there seems to be a dual function with intact GLP-1 (7-36), acting through the GLP-1…
- Trial name
- NCT02333591
- Testing
- GlucagonLikePeptide-1 (7-36), GlucagonLikePeptide-1 (9-36), Saline
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mette Zander
Patients With INOCA(Ischemia and no Obstructive Coronary Artery Disease) Who Have Coronary Microvascular Dysfunction
Effect of Trimetazidine on the Improvement of Coronary Microvascular Dysfunction in Patients With INOCA(Ischemia and no Obstructive Coronary Artery Disease)
This is a prospective study which aims to explore the effect of Trimetazidine on the improvement of coronary microvascular dysfunction in patients with INOCA (ischemia and no obstructive coronary artery disease).
- Trial name
- T-MICRO (NCT03504202)
- Testing
- Trimetazidine
- Volunteers
- 10 people
- Sponsor
- Shanghai 10th People's Hospital
Coronary Microvascular Dysfunction, Metabolic Syndrome
Microcirculation Assessment in Diabetes and Metabolic Syndrome
Abnormal coronary microvascular vasodilation has been demonstrated in patients with diabetes and metabolic syndrome, but the role of insulin resistance in its pathogenesis is not clear.
- Conditions
- Coronary Microvascular Dysfunction, Metabolic Syndrome, Diabetes
- Trial name
- MADAME (NCT01014949)
- Testing
- Coronary microcirculation assessment
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- S.M. Misericordia Hospital