Clinical trials: Microvascular Disease, open to volunteers
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Non-obstructive Coronary Disease, Acute or Chronic Coronary Artery Disease
Simultaneous Measurement of EpicArdial and Microvascular ResisTance Via Angiographic FLOW Study
The aim of this study is to establish the diagnostic performance of the AngioAI+ System (AngioInsight, Inc, USA) for estimating: 1. Fractional flow reserve (FFR) and 2.
- Trial name
- SMARTFLOW (NCT07676097)
- Testing
- Patients with intermediate coronary artery stenosis with clinically indicated FFR assessment., Microvascular assessment
- Where
- 9 sites in United States
- Volunteers
- 620 people
- Sponsor
- AngioInsight
Peripheral Artery Disease
The Value of Super-resolution Ultrasound Imaging for Peripheral Artery Disease
Peripheral artery disease (PAD) is a chronic atherosclerotic disorder characterized by stenosis or occlusion of the extracranial arteries distal to the aortic arch, most commonly affecting the lower extremities.
- Trial name
- NCT07374601
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Hepatocellular Carcinoma Resectable, Surgery
Compare the Accuracy of ctDNA-MRD and MVI Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma
The aim of this study was to compare the accuracy of ctDNA-MRD longitudinal surveillance model and internationally accepted pathological MVI results in predicting recurrence after radical hepatectomy.
- Conditions
- Hepatocellular Carcinoma Resectable, Surgery, Recurrence
- Trial name
- NCT06449846
- Testing
- circulating tumor cell DNA detection
- Where
- 4 sites in China
- Volunteers
- 152 people
- Sponsor
- Zhujiang Hospital
Coronary Microvascular Disease
Clinical Evaluation of Aromatic Wentong in the Treatment of Coronary Microvascular Disease
Coronary Microvascular Disease (CMD) is a condition where patients experience chest pain (angina) even though their coronary arteries appear normal on angiography.
- Trial name
- NCT06901570
- Testing
- Kuangxiong Aerosol
- Where
- China
- Volunteers
- 528 people
- Sponsor
- China-Japan Friendship Hospital
Coronary Microvascular Dysfunction, Ischaemia With Non Obstructed Coronary Arteries
Mechanisms Behind Microvascular Dysfunction in INOCA
The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.
- Trial name
- ExINOCA-P1 (NCT06529861)
- Testing
- [15O]H2O-PET Imaging
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Coronary Microvascular Disease
An Observational Study of Coronary Microvascular Disease of China
Non-obstructive coronary heart disease refers to patients with angina pectoris without significant narrowing of the epicardial vessels.
- Trial name
- CCMD (NCT06676137)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Myocardial Ischemia
Comparative Study of Magnetocardiography and Emission Computed Tomography.
Coronary atherosclerotic heart disease (CHD) and Coronary Microvascular Disease (CMVD), as the primary etiologies of myocardial ischemia, have garnered increasing clinical attention due to their high prevalence and severe…
- Trial name
- NCT07078266
- Testing
- Magnetocardiography examination
- Volunteers
- 218 people
- Sponsor
- Yang Jing
Congenital Heart Disease
International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in Congenital and Acquired Heart Disease
The international multicenter registry aims to collect real-world data on clinical outcomes and evaluate the net clinical success of transcatheter microvascular plug (MVP)-based pulmonary flow restrictors (PFRs) in patients with…
- Trial name
- RESTRICT (NCT07791069)
- Testing
- Transcatheter pulmonary flow restriction
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 150 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Chronic Kidney Disease
Nicotinamide Riboside Supplementation in Chronic Kidney Disease
This study is testing whether a dietary supplement called nicotinamide riboside, (NR), can be used in adults with moderate chronic kidney disease. NR is a form of vitamin B3 that may help support cellular energy metabolism.
- Trial name
- NR-CKD (NCT07693543)
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Gestational Diabetes
Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
The purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in…
- Trial name
- NCT05917587
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Type 2 Diabetes
A Registry-based Randomized Controlled Trial in Type 2 Diabetes With Cardiovascular Risk Factors (REMATCH)
Glycemic control is a mainstay of diabetes management to reduce the risk of microvascular complications and cardiovascular outcomes in people with type 2 diabetes (T2D).
- Trial name
- REMATCH (NCT06627322)
- Testing
- Dual-combination therapy, Triple-combination therapy, Dexcom G7, Pasta
- Where
- 2 sites in South Korea
- Volunteers
- 5,950 people
- Sponsor
- Kyu Chang Won
ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction
Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution
The goal of this observational study to measure the heart's microvascular function in the setting of a myocardial infarction (MI), or heart attack, using a method called continuous saline thermodilution (CST).
- Conditions
- ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction, Microvascular Obstruction
- Trial name
- ConMICRO (NCT06795035)
- Testing
- Continuous Saline Thermodilution
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- The Cleveland Clinic
Septic Shock, Sepsis
Effects of Anisodamine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm, open-label interventional pilot study aims to evaluate the short-term physiological effects of intravenous anisodamine on sublingual microcirculation and vascular-waterfall parameters in…
- Conditions
- Septic Shock, Sepsis, Critical Illness
- Trial name
- ANISO-MICRO (NCT07657702)
- Testing
- Anisodamine intravenous infusion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Coronary Artery Disease, Coronary Microvascular Disease
The FLARE (Flurpiridaz vs. Rubidium Evaluation) Trial
This study seeks to evaluate if the diagnostic performance of 18F-flurpiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI), given the radiotracer's properties, is non-inferior to the currently most widely…
- Trial name
- FLARE (NCT07761728)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Hypertension
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy
The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced hypertension during pregnancy and…
- Trial name
- CARDAMOM (NCT07238400)
- Testing
- Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Chloride
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Nebivolol ANOCA Treatment Randomized Trial
To determine the effectiveness of the beta-blocker nebivolol in controlling symptoms and improving the quality of life in patients with angina and coronary microvascular dysfunction.
- Trial name
- MOTORS (NCT06755801)
- Testing
- Nevibolol
- Volunteers
- 150 people
- Sponsor
- Spanish Society of Cardiology
Hypertension, Left Ventricular Hypertrophy
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
The investigators' goal is to show that in hypertensive men and women with left ventricular hypertrophy (LVH) treatment with a mineralocorticoid receptor (MR) antagonist, versus a thiazide-like diuretic, will improve coronary…
- Trial name
- NCT05593055
- Testing
- Eplerenone, Chlorthalidone, Potassium
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
Diabetic Ketoacidosis, Diabetes Mellitus
Leukocyte Glucose Index and Severity of Diabetic Ketoacidosis
This prospective cohort study aims to evaluate the relationship between admission Leukocyte Glucose Index (LGI) and the severity of diabetic ketoacidosis, as well as the presence of diabetic microvascular complications, among…
- Trial name
- NCT07821814
- Volunteers
- 120 people
- Sponsor
- Assiut University
Menopause, Perimenopause
Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition
The goal of this clinical trial is to learn whether it is feasible to conduct a larger study comparing transdermal menopausal hormone therapy (MHT) versus no hormone therapy in menopausal women with vasomotor symptoms (hot…
- Conditions
- Menopause, Perimenopause, Vasomotor Symptoms, Cardiovascular Disease Risk Factor
- Trial name
- HERBRAVEHEART (NCT07732452)
- Testing
- Transdermal estradiol, Standard of care - non hormonal
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre