Clinical trials: Microvascular Ischemia of Myocardium
Coronary Cicrovascular Dysfunction, Hypertrophic Cardiomyopathy Patients
Prognostic Significance of CMD Assessed by IMR in HCM Patients
The index of microcirculatory resistance (IMR) serves as an indicator of coronary microvascular dysfunction (CMD) with significant prognostic value in various clinical conditions.
- Trial name
- caIMR-HCM (NCT06190704)
- Testing
- caIMR
- Volunteers
- 191 people
- Sponsor
- Ya-Wei Xu
Coronary Microvascular Dysfunction
A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Online Coronary Angiography-Derived Index of Microcirculatory Resistance (caIMR)
More than 50% of patients with stable or unstable angina pectoris have no obstructive coronary arteries by angiographic visual estimation, in which coronary microvascular dysfunction (CMD) is one of the causes of myocardial…
- Trial name
- Flash III (NCT05009667)
- Testing
- Angiography-derived Index of Microcirculatory Resistance, Pressure wire-based Index of Microcirculatory Resistance
- Where
- 3 sites in China
- Volunteers
- 116 people
- Sponsor
- Ge Junbo
Coronary Microvascular Dysfunction
Effect of Intact GLP-1 (7-36) and GLP-1 Metabolite (9-36) on Coronary and Peripheral Vascular Function in Adults
GLP-1 is an agent for treatment of type 2 diabetes and may have protective effects on the cardiovascular system. The mechanism is complex and there seems to be a dual function with intact GLP-1 (7-36), acting through the GLP-1…
- Trial name
- NCT02333591
- Testing
- GlucagonLikePeptide-1 (7-36), GlucagonLikePeptide-1 (9-36), Saline
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mette Zander
Sepsis, Myocardial Injury
COronary Microcirculation and Troponin Elevation in Septic Shock
Plasma cardiac troponin (cTn) elevation is an indicator of increased mortality in patients with sepsis yet the underlying cause of troponin elevation in sepsis is not known.
- Conditions
- Sepsis, Myocardial Injury, Coronary Microvascular Dysfunction, Endothelial Dysfunction
- Trial name
- COMTESS (NCT06294730)
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Karolinska Institutet
Coronary Microvascular Dysfunction
A Study on the Impact of Bivalirudin Usage During PCI for High-risk Plaques on Post-PCI Coronary Microcirculation.
In this study, investigators enrolled patients with coronary heart disease who were scheduled to undergo percutaneous coronary intervention (PCI) and had high-risk plaques according to computed tomography angiography (CTA).
- Trial name
- PCI (NCT05984537)
- Testing
- Bivalirudin, standard heparin
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
Coronary Microvascular Dysfunction (CMD)
PRECISE Phenotyping to Guide Therapies for Coronary Microvascular Dysfunction
Some people experience chest pain and shortness of breath, but when they have tests, no blockages are found in their main heart arteries.
- Trial name
- PRECISE-CMD (NCT07533747)
- Testing
- Empagliflozin 10mg OD
- Volunteers
- 100 people
- Sponsor
- King's College London
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Absolute Flow for Ischemia With No Obstructive Coronary Arteries
The main objective is to prospectively validate the capacity of continuous thermodilution coronary flow reserve (CFRflow) as a predictor of the presence of angina measured by SAQ7 in patients with INOCA at 3 months.
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Angina, Stable
- Trial name
- AF-INOCA (NCT05825339)
- Testing
- Coronary Flow Reserve
- Where
- 6 sites in Spain
- Volunteers
- 121 people
- Sponsor
- Spanish Society of Cardiology
Coronary Microvascular Dysfunction (CMD), Angina Patients With Non-obstructive Coronary Artery Disease
Inorganic Nitrate as a Treatment for ANOCA: NO-ANOCA
The purpose of this study is to see if inorganic nitrate in the form of beetroot juice helps blood flow and physical fitness in women with ANOCA and CMD.
- Trial name
- NO-ANOCA (NCT06948201)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia