Clinical trials: Microvascular Resistance
Microvascular Angina, Microvascular Coronary Artery Disease
EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial
Rationale: coronary microvascular disease is a relatively 'new' entity within the field of cardiology. The investigators are able to investigate the microcirculation by measurements performed in the catheterization laboratory.
- Conditions
- Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Vasospasm, Microvascular Resistance
- Trial name
- EURO-ccraft (NCT04598308)
- Testing
- absolute flow and resistance measurements
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction
AccuIMR Predicts Microvascular Obstruction and Infarct Size in STEMI Patients
In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR…
- Conditions
- Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery Disease
- Trial name
- NCT06947564
- Testing
- CMR
- Where
- China
- Volunteers
- 843 people
- Sponsor
- RenJi Hospital
Severe Symptomatic Aortic Stenosis
Change in Coronary Microcirculation and FFR After TAVI in Patients With Cardiovascular Comorbidities
Change in coronary microcirculation and Fractional Flow Reserve after Transcatheter Aortic Valve Implantation in patients with concomitant coronary artery disease and severe aortic stenosis.
- Trial name
- NCT04663334
- Testing
- inverse myocardial remodeling
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Hypertrophic Cardiomyopathy
Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy
Hypertrophic cardiomyopathy (HCM) is a common heart condition in which the heart muscle becomes abnormally thick. In non-obstructive HCM, blood flow out of the heart is not blocked, but many patients still experience chest pain…
- Trial name
- COSMIC-HCM (NCT07865364)
- Testing
- Coronary sinus reducer
- Where
- 8 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Insulin Resistance
Microvascular Insulin Resistance and Mixed Meal Challenge
Insulin resistance (or pre-diabetes) is diagnosed using the oral glucose tolerance test. However, high blood glucose levels during this test may adversely impact on microvascular function.
- Trial name
- NCT02708875
- Testing
- Mixed Meal Challenge, Glucose Challenge
- Where
- 2 sites in Australia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease
Microvascular Coronary Resistance and Absolute Coronary FLOW in Patients With Percutaneous Intervention of a Chronic Total Occlusion
It is an observational study which objective is to analyze, through a series of invasive parameters, the state of the coronary microvasculature immediately after the successful percutaneous coronary intervention of a chronic…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease, Coronary; Ischemic, Coronary Microvascular Dysfunction
- Trial name
- FLOW-CTO (NCT05197361)
- Testing
- Invasive coronary physiology
- Where
- 4 sites in Spain
- Volunteers
- 34 people
- Sponsor
- Parc de Salut Mar
Coronary Microvascular Dysfunction, Resistant Hypertension
Impact of Renal Denervation in Patients With Coronary Microvascular Dysfunction: Study Design and Rationale
Long-standing hypertension may cause an impairment in microvascular coronary circulation which is involved in many different cardiac conditions.
- Conditions
- Coronary Microvascular Dysfunction, Resistant Hypertension, Hypertensive Heart Disease
- Trial name
- IMPRESSION (NCT05994729)
- Testing
- Invasive Physiological Assessment of Coronary Circulation
- Volunteers
- 87 people
- Sponsor
- Aurelia Hospital
Microvascular Coronary Artery Disease, STEMI
Clinical Trial for Evaluating the Effectiveness and Safety of Online caIMR in STEMI Patients
Despite the success of restoration of epicardial blood flow by the primary percutaneous coronary intervention (PPCI), approximately a half of patients with ST-segment elevation myocardial infarction (STEMI) have failed myocardial…
- Trial name
- FlashIV (NCT06118450)
- Testing
- Non-intervention
- Where
- 8 sites in China
- Volunteers
- 335 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris
A Multi-center, Real-World Clinical Trial of caIMR on Two Specific Kinds of Patients.
The coronary angiography-derived index of microcirculatory resistance (caIMR) can be used to provide a binary assessment whether patients（with stable angina, unstable angina, suspected myocardial ischemia, or coronary artery…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris, Unstable Angina Pectoris, Myocardial Ischemia, Angina Pectoris
- Trial name
- FlashV (NCT06945094)
- Testing
- caIMR
- Volunteers
- 508 people
- Sponsor
- Ge Junbo
Diabetes Mellitus, Type 2
Skin and Retina Microvascular Endothelial Function in Healthy, Insulin Resistant and Type 2 Diabetic Subjects
The purpose of this study is to investigate microvascular endothelial function in the retina of lean, obese, and type 2 diabetic subjects and to compare microvascular endothelial function in the retina with several other…
- Trial name
- NCT01241370
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- ELAB-Logistics
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital