Clinical trials: Microvasculature
Congestive Heart Failure
Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease
Hypothesis: Tissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of…
- Trial name
- NCT01099982
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Fabry Disease, Endothelial Dysfunction
Characterizing the Retinal Microvasculature in Patients with Fabry Disease: a Prospective Observational Study
This study aims to gain a deeper understanding of endothelial dysfunction in patients with Fabry disease through a prospective study of the retinal microvasculature and to identify an objective, non-invasive marker to assess…
- Conditions
- Fabry Disease, Endothelial Dysfunction, Microvasculature
- Trial name
- VASCinFABRY (NCT06758648)
- Testing
- Dynamic retinal vessel analysis (DVA), Biochemistry and immune phenotyping, Questionnaires (Patient reported outcomes)
- Where
- Germany
- Volunteers
- 63 people
- Sponsor
- Technical University of Munich
Health Status
Effect of Fibre Supplementation on Mixed-meal Challenge Response
Improving healthy physiological processes through nutritional intervention, as opposed to restoring physiology after disease occurrence, is an important new avenue for the reduction of disease burden in the population.
- Trial name
- NCT04829396
- Testing
- Fibre mixture
- Where
- Netherlands
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
Mandibular Reconstruction, Maxillofacial Injuries
Anatomical Research of the Clavicular Pedicled Flap for Mandibular Reconstruction
Because of the proximity of the clavicular bone to the oral cavity, and the suitable characteristics of the bone for implant placement, its use as a pedicled flap is an attractive method of mandibular reconstruction.
- Trial name
- NCT06255483
- Testing
- Osteoperiosteal pedicled clavicular flap for mandibular and facial bone reconstruction
- Where
- Tunisia
- Volunteers
- 10 people
- Sponsor
- Mohamed Tahar Maamouri University Hospital
Cognitive Impairment, Progressive, Cerebral Small Vessel Diseases
Circuit Training and Retina
The purpose of this research study is to see if high-speed weight training performed in a circuit (using one machine after another) can improve participant heart and brain function, strength, and power in older persons.
- Trial name
- NCT05714813
- Testing
- High-Speed Circuit Resistance Training, Lecture on Diet, Exercise and Cognition
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
OCTA Changes With Local Anesthesia
Oct Angiography Changes After Local Anesthesia in Cataract Surgery
Assessement of retinal microvasculature detected by OCT-angio after peribulbar \&retrobulbar anesthesia in cases undergoing cataract surgery .
- Trial name
- NCT07298746
- Testing
- Local Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML), Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML), Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML)
- Volunteers
- 100 people
- Sponsor
- Sohag University
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Dyslipidemia
Resveratrol and Serum Apo A-I
Although much effort has been done to lower LDL-cholesterol concentrations, there is still a substantial risk for cardiovascular disease (CVD). Another strategy to lower the risk for CVD is elevating the HDL-cholesterol (HDL-C).
- Trial name
- NCT01364961
- Testing
- Resveratrol capsules
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type2 Diabetes, Insulin Sensitivity
Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes
The aim is to test in T2DM patients, whether, compared to placebo, 12 weeks of SGLT-2 inhibitor improves post-absorptive, post-insulin infusion or postprandial insulin action to enhance Cardiac Muscle vascular function and…
- Trial name
- EJB051 (NCT04203927)
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Balance Disorders, Accidental Falls
Population Cohort Set-up for the Epidemiological Assessment of Balance Disorders in Elderly People
As people age, it becomes more common to experience balance problems. These issues can increase the risk of falling, which may lead to serious health consequences and loss of independence.
- Conditions
- Balance Disorders, Accidental Falls, Frailty, Aging
- Trial name
- EPIBAS (NCT06965660)
- Where
- Spain
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Myopia
Optical Coherence Tomography Angiography in Myopic Patients
The aim of this study is to investigate the macular microvascular network alterations in high myopic eyes using optical coherence tomography angiography.
- Trial name
- NCT04135209
- Testing
- Optical coherence tomography angiography OCTA
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Minia University
Preeclampsia (PE), Endothelial Dysfunction
Does Nicotine Influence the Risk of Preeclampsia?
This prospective cohort study explores the long-term impact of pre-pregnancy smoking on vascular health in women predisposed to preeclampsia, conducted at the Medical University of Graz.
- Conditions
- Preeclampsia (PE), Endothelial Dysfunction, Hypertension in Pregnancy
- Trial name
- PRE_Smoking (NCT06645340)
- Testing
- This high-risk cohort underwent the same measurements during pregnancy: endothelial function, arterial stiffness, retinal microvasculature profile, measurement of Neprilysin, cotinine, telomere length
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Circumscribed Choroidal Haemangioma, Optical Coherence Tomography Angiography
Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes With Exudative Circumscribed Choroidal Haemangioma: An Optical Coherence Tomography Angiography Study
The study aims to quantitative evaluation of parafoveal microvasculature changes in eyes with exudative circumscribed choroidal haemangioma using optical coherence tomography angiography.
- Conditions
- Circumscribed Choroidal Haemangioma, Optical Coherence Tomography Angiography, Macular
- Trial name
- NCT04449900
- Testing
- This is observational study with the examination of OCTA
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cognitive Change
Yoga Training and Retinal Vasculature
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function.
- Trial name
- NCT06099405
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional yoga
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Coronary Microvascular Dysfunction, Cardiotoxicity
Effects of Immune Checkpoint Inhibitors on Coronary Microvasculature
This is an observational study that includes patients with breast cancer or non-small cell lung cancer who will be treated with immune checkpoint inhibitor (ICI) therapy.
- Conditions
- Coronary Microvascular Dysfunction, Cardiotoxicity, Breast Cancer, Lung Cancer (NSCLC)
- Trial name
- NCT06332131
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Diabetic Retinopathy, Type 1 Diabetes
Effect of Omega-3 Fatty Acids on Eye Blood Vessels in Type 1 Diabetes
This double-blind, placebo-controlled randomized clinical trial evaluates the effects of omega-3 fatty acid supplementation on retinal vascular structure and function in children and adolescents with type 1 diabetes.
- Conditions
- Diabetic Retinopathy, Type 1 Diabetes, Omega 3 Fatty Acids
- Trial name
- O3RETINA (NCT07255326)
- Testing
- Omega 3 Fish Oil supplements
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- University of Faisalabad
Patients With Primary Nasal Pterygium
Effects of Ranibizumab in Primary Pterygium Surgery
Pterygium is a common ocular surface disease in Malaysia. Without treatment, it can lead to severe visual impairment. Recurrence is the commonest complication and novel treatment approaches are crucial to prevent vision loss.
- Trial name
- NCT04878835
- Testing
- intralesional ranibizumab
- Where
- Malaysia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Autosomal Dominant Polycystic Kidney Disease
Intrarenal Microvasculature in ADPKD
The primary objective of this study is to evaluate the use of Super-resolution ultrasound (SRU) to assess the intrarenal microvasculature in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and healthy…
- Trial name
- NCT05288998
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Microvascular Dysfunction, Microvasculature
Palmitic Acid and Human Microvascular Function
The goal of this study is to learn how a supplement Quercetin can affect microvascular function. Participants will: give two blood draws of 5 mL each have a camera placed under the tongue to take pictures of blood vessels have 2…
- Conditions
- Microvascular Dysfunction, Microvasculature, Cardiovascular Diseases, Cardiovascular Diseases (CVD)
- Trial name
- NCT06683534
- Testing
- Quercetin (dietary supplement)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Breast Carcinoma, Breast Neoplasm
Quantitative Microvasculature Imaging for Breast Cancer Detection and Monitoring
This study evaluates the effectiveness of a breast ultrasound method for the diagnosis of breast cancer. Diagnostic procedures, such as breast ultrasound, may help find and diagnose breast cancer, and may help measure a patient's…
- Trial name
- NCT04799535
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Mayo Clinic