Clinical trials: Midazolam
Sedation and Analgesia
Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam
In this parallel, multicenter, single-blind randomized controlled trial, mechanical ventilated patients will be randomly assigned to two groups.
- Trial name
- NCT05160987
- Testing
- Remimazolam, Midazolam
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Zhujiang Hospital
Inhalational Anesthetics Adverse Reaction, Delirium on Emergence
Effects of Dexmedetomidine Premedication on Emergence Agitation After Strabismus Surgery in Children
Sevoflurane is frequently used for pediatric anesthesia because it has low pungency and rapid onset and offset of action.The reported incidence of emergence agitation (EA) following sevoflurane anesthesia varies from 10-80%.
- Conditions
- Inhalational Anesthetics Adverse Reaction, Delirium on Emergence, Strabismus Following Ocular Surgery
- Trial name
- NCT01895023
- Testing
- Dexmedetomidine, Midazolam, Saline
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Yao Yusheng
Acute Agitated Patients
Randomized Double-blind Trial of Midazolam and Loxapine in Agitated Patients
Neuroleptics are used since a long time in the management of severely agitated patients. Loxapine is routinely used in our country, with, to our knowledge no severe adverse event reported, in this indication.
- Trial name
- NCT00290082
- Testing
- loxapine, midazolam, blood sample, patient monitoring
- Where
- 21 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Behavior Problem
Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children
The goal of this clinical trial is to learn the effect of dexmedetomidine premedication in postoperative negative behavior changes in children compared to midazolam premedication.
- Trial name
- NCT06417125
- Testing
- Dexmedetomidine Hydrochloride, Midazolam, normal Saline
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Fujian Provincial Hospital
Gastro-Esophageal Reflux Disease With Ulceration
The 90% Effective Sedation Dose Of Midazolam
There are no clear conclusive clinical reports defining the adequate effective dose of midazolam in patients undergoing day-case esophageal-gastro-duodenoscopy (EGD).
- Trial name
- NCT03813043
- Testing
- Midazolam injection
- Volunteers
- 40 people
- Sponsor
- King Fahad Specialist Hospital Dammam
Postoperative Nausea, Postoperative Vomiting
Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy
In the present study, midazolam and palonosetron in combination were more effective than palonosetron alone in lowering the incidence and severity of postoperative nausea and vomiting in the initial 2 h after laparoscopic…
- Trial name
- NCT03933605
- Testing
- midazolam and palonosetron group, palonosetron group
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Yeungnam University College of Medicine
Healthy
Study of Edasalonexent With Midazolam and Deflazacort in Healthy Subjects
Drug-drug interaction (DDI) and Cardiodynamic Evaluation Study To assess the effect of multiple oral doses of edasalonexent on the single-dose pharmacokinetics (PK) of midazolam (a cytochrome P450 [CYP]3A4 sensitive substrate)…
- Trial name
- NCT04543370
- Testing
- Edasalonexent 2000 mg TID, Midazolam 2 MG/ML, Deflazacort 36Mg Tab
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Catabasis Pharmaceuticals
Solid Tumors
Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension)
The purpose of this extension study is to evaluate the potential inhibitory effects of patupilone on metabolism using midazolam and omeprazole as the respective probe drugs.
- Trial name
- NCT00442741
- Testing
- Patupilone, Patupilone + Omeprazole
- Sponsor
- Novartis Pharmaceuticals
Ruptured Cerebral Aneurysm
Effect of Propofol Midazolam on Cerebral Oxygenation and Metabolism During Clipping of Ruptured Cerebral Aneurysm
Despite the theoretical benefits of i.v. agents, volatile agents remain popular. In a study comparing desflurane, isoflurane, and sevoflurane in a porcine model of intracranial hypertension, at equipotent doses and normocapnia…
- Trial name
- NCT03778723
- Testing
- Total intravenous anesthesia (TIVA), Inhalation Anesthesia, Rescue fentanyl
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
General Anesthesia, Aged
Remimazolam Versus Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery
This prospective observational cohort study evaluates the effectiveness and safety of two benzodiazepine sedatives-remimazolam and midazolam-used for general anesthesia induction in elderly patients (≥65 years) undergoing…
- Conditions
- General Anesthesia, Aged, Intraoperative Hypotension, Anxiety
- Trial name
- NCT07746505
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pediatric Cancer, Analgesia
Intranasal Versus Intravenous Drug in Painful Procedure for Outpatient Oncologic Participants
Pain is a vital sign that depends on personal experience involving different factors such as previous sensory and emotional experience, age, spiritual and cultural aspects, that makes it harder to evaluate, especially in young…
- Conditions
- Pediatric Cancer, Analgesia, Procedural Pain
- Trial name
- NAIVe (NCT04621110)
- Testing
- intranasal dexmedetomidine, intranasal fentanyl, intravenous ketamine (ketalar®)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Neurocognitive Disorders
Efficacy and Safety of Oral Midazolam Used for the Delivery of Care in Elderly Patient With Neurocognitive Disorders and Refusing Care.
The purpose of this study is to assess the effectiveness of oral midazolam on the delivery of care in elderly patients with moderat to severe neurocognitive disorders and opposing care.
- Trial name
- MIRAGE (NCT06638710)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Epilepsy
Emergency Medical Services and Epilepsy in Switzerland
Retrospective data analysis, all emergency medical services of the city of Zurich interventions due to epileptic convulsions during June 2013 and December 2014 have been analyzed regarding the type of drug used, its application…
- Trial name
- NCT03346382
- Volunteers
- 584 people
- Sponsor
- Theusinger Oliver M.
Strabismus, Reflex, Oculocardiac
Hydroxyzine Dihydrochloride Premedication is a Necessity for Strabismus Surgery
Oculocardiac reflex (OCR) is usually happening in pediatric strabismus surgery and observed just when the surgent pulls the ocular muscles.
- Conditions
- Strabismus, Reflex, Oculocardiac, Hydroxyzine, Bradycardia Sinus
- Trial name
- NCT03806270
- Testing
- Midazolam, Hydroxyzine Dihydrochloride
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Yeditepe University
Hepatitis B, Chronic
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants
This study is a multicenter, three-part study. Parts 1 and 2 are randomized, investigator- and participant-blinded, placebo-control, single-ascending dose (SAD) and multiple-ascending dose (MAD) study to evaluate the safety…
- Trial name
- NCT02952924
- Testing
- Midazolam, RO7049389
- Where
- 21 sites in Australia, Bulgaria and 6 more
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Preoperative Sedation
Intranasal Dexmedetomidine Premedication in Children
BACKGROUND INFORMATION AND RATIONALE Pediatric patients scheduled for dental procedures under general anesthesia can have significant anxiety before the procedure.
- Trial name
- NCT02250703
- Testing
- Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Mississippi Medical Center
Midazolam Overdose
Measurement of Midazolam Levels in Follicular Fluid
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics. The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature…
- Trial name
- NCT03049293
- Testing
- Midazolam
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Endometriosis
Drug-drug Interaction Study Between Orally Administered Rifampicin and Vilaprisan
This study will be conducted in a single center, open-label study with a single group fixed sequence design to evaluate the effect of repeated oral administration of 600 mg RIF(Rifampicin) given once daily over 11 days on the…
- Trial name
- NCT02975440
- Testing
- Rifampicin, Midazolam, BAY1002670_Vilaprisan
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bayer