Clinical trials: Middle Age
Primary Health Care
Individualizing Disease Prevention for Middle-Aged Adults
The primary objective of this study is to help patients compare the benefits of various preventive care services, based on their individual risk factors (such as smoking status, obesity, high blood pressure, high cholesterol…
- Trial name
- NCT03023813
- Testing
- Intervention
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Glen Taksler
Sedentary Behavior, Cardiovascular Risk Factor
Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
Prolonged sitting may pose a public health risk through its effects on the cardiovascular system, and may lead to impaired whole-body cardiovascular health, which includes both vascular and cerebrovascular function.
- Conditions
- Sedentary Behavior, Cardiovascular Risk Factor, Mental Stress, Cognitive Change
- Trial name
- NCT04207333
- Testing
- Mental Arithmetic Test
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Disease, Type 2 Diabetes
Physical Health in Midlife: Influences of Adversity and Relationships Over Time
The purpose of this study is to determine the effects of individual characteristics, life stresses, and relationships over time on psychosocial outcomes (e.g. marriage, parenting, work) and physical health
- Trial name
- NCT01853332
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Beth Israel Deaconess Medical Center
Aging, Cognitive Change
Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.
- Trial name
- NCT05652140
- Testing
- Data collections
- Where
- Taiwan
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Suicide Prevention
A Novel Cognitive Reappraisal Intervention for Suicide Prevention
The goal of this trial is to refine and test a novel emotion-regulation based psychosocial intervention designed to reduce suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a…
- Trial name
- CRISP (NCT03026127)
- Testing
- Cognitive Reappraisal Intervention for Suicide Prevention, Supportive Therapy
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Weill Medical College of Cornell University
Degenerative Meniscal Tear
Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears
This study is conducted as a collaboration between NAR, Orthopedic Department, Oslo University Hospital,Ullevaal, Hjelp24Nimi Oslo, Martina Hansens Hospital Norway, and University of Southern Denmark, Odense, Denmark.
- Trial name
- OMEX (NCT01002794)
- Testing
- Arthroscopic partial menisectomy, Supervised neuromuscular and strength training
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Oslo University Hospital
Hyperinsulinemia, Insulin Resistance
EMPOWIR:Enhance the Metabolic Profile of Women With Insulin Resistance
The goal of the study is to identify and treat women with midlife weight gain who have normal blood sugars, but increased insulin levels (hyperinsulinemia) following the performance of a glucose tolerance test.
- Conditions
- Hyperinsulinemia, Insulin Resistance, Obesity
- Trial name
- EMPOWIR (NCT00618072)
- Testing
- metformin and rosiglitazone
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Cardiovascular Risk Factor, Stress
Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)
This research study examines the unique cultural and gender-based factors that influence how midlife Black women experience stress and incorporate healthy lifestyle behaviors into daily life.
- Conditions
- Cardiovascular Risk Factor, Stress, Self Efficacy, Depressive Symptoms
- Trial name
- B-SWELL (NCT04404478)
- Testing
- B-SWELL: Midlife Black Women's Stress Reduction Wellness Program, WE: Wellness program for Midlife Black Women
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Middle-aged Adults, Major Depressive Disorder
Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults.
- Trial name
- NCT06466655
- Testing
- MitoTempol, Lactated Ringer's (control)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Brain Health, Gestational Hypertension
Brain Health in Midlife
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
- Conditions
- Brain Health, Gestational Hypertension, Alzheimer Disease, Dementia
- Trial name
- ADORE BRAIN (NCT06640842)
- Testing
- A combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Diarrhoea
A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants
The aim of the current clinical study was to evaluate, for the first time in humans (FTIH), the safety and immunogenicity of the altSonflex1-2-3 candidate vaccine against S. sonnei and S. flexneri serotypes 1b, 2a, and 3a.
- Trial name
- NCT05073003
- Testing
- AltSonflex1-2-3 High Dose, AltSonflex1-2-3 Medium Dose, AltSonflex1-2-3 Low Dose
- Where
- 2 sites in Belgium, Kenya
- Volunteers
- 551 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus, Cognitive Impairment
Intensive Aerobic and Resistance Exercise Program (IAREP)
A 12-week Intensive Aerobic and Resistance Exercise Program (IAREP) intervention was implemented on high-risk and low-risk subjects with cognitive impairment in type 2 Diabetes Mellitus.
- Conditions
- Type 2 Diabetes Mellitus, Cognitive Impairment, Non-insulin-dependent Diabetes Mellitus, Cognitive Dysfunction
- Trial name
- NCT06401733
- Testing
- Intensive Aerobic and Resistance Exercise Program (IAREP)
- Where
- Singapore
- Volunteers
- 58 people
- Sponsor
- National University of Singapore
Age-related Volume Deficit in the Mid-face
The Volumizing Effect of Juvéderm VOLUMA® in the Mid-Face
This is a prospective, observational study of the volumizing effect of aesthetic use of Juvéderm VOLUMA® with lidocaine in the mid-face area.
- Trial name
- NCT01559064
- Testing
- Crosslinked hyaluronic acid gel (Juvéderm VOLUMA®)
- Where
- 4 sites in Belgium, Germany and 2 more
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Allergan Medical
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Substance Use, Parenting
Feasibility Study of a Web-based Program to Help Parents of Middle School Students Effectively Communicate With Their Children About Substance Use
The goal of this study is to test the feasibility of a web-based program for parents of middle school aged students. 286 parents and their child in 6th, 7th, or 8th grade will be asked to each complete two online questionnaires…
- Conditions
- Substance Use, Parenting, Communication
- Trial name
- NCT05900115
- Testing
- Media Ready Parent, Active Control Program
- Where
- United States
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Innovation Research & Training
Hypertension
Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults
The investigators hypothesize that reducing salt in the diet will improve the function of blood vessels in middle aged and older adults with moderately elevated systolic blood pressure, by increasing the amount of BH4 and nitric…
- Trial name
- NCT01566084
- Testing
- Slow sodium tablets
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Women's Health, Insomnia
A Study of MUSE Device for Midlife Women
The purpose of this study is to see if it is feasible for midlife women to wear a brain activity sensing headband (Muse-S) for management of sleep disturbances such as insomnia and sleep disruption
- Conditions
- Women's Health, Insomnia, Sleep Disturbance
- Trial name
- NCT05972486
- Testing
- Muse-S™ headband system
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Adults, Older Adults
Effects of RLIC on Motor Learning in Middle-aged and Older Adults
The purpose of this research is to determine if the beneficial effects of remote limb ischemic conditioning on learning seen in young adults are found in middle-aged and older adults.
- Trial name
- NCT03582943
- Testing
- RLIC, Balance training
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Insomnia
Efficacy of Suvorexant in the Treatment of Hot Flash-associated Insomnia
The aim of this study is to determine the effect of suvorexant on insomnia symptoms in peri- and postmenopausal women who are experiencing sleep difficulties related to nighttime hot flashes.
- Trial name
- NCT03034018
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
HIV, Risky Sex Prevention
A Risky Sex Prevention Intervention for Middle School Age Minority Girls
African American adolescent females are more likely to have sex at an early age, to have older sex partners that have had multiple sexual experiences, and are less likely to use a condom than their white counterparts.
- Trial name
- GEMM (NCT02103218)
- Testing
- Education, activities, empowerment, racial pride building, General Health education, activities
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- University of North Carolina, Greensboro