Clinical trials: Middle Age
Aging
Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults
The objective of the clinical trial is to evaluate the mediating influence of force control on the pegboard times of adults (50-89 years) who are stratified into groups of faster and slower pegboard times.
- Trial name
- NCT03803566
- Testing
- Pegboard practice, Force control practice
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
HIV, Risky Sex Prevention
A Risky Sex Prevention Intervention for Middle School Age Minority Girls
African American adolescent females are more likely to have sex at an early age, to have older sex partners that have had multiple sexual experiences, and are less likely to use a condom than their white counterparts.
- Trial name
- GEMM (NCT02103218)
- Testing
- Education, activities, empowerment, racial pride building, General Health education, activities
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- University of North Carolina, Greensboro
Estrogen, Premenopause
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.
- Trial name
- V-RISES (NCT06745466)
- Testing
- ganirelix acetate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Obesity
Telenutrition Center: Examining the Implementation of Behavioral Therapy for Obesity
The Telenutrition Center will use the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) Framework to assess the implementation of an evidence-based, intensive behavior therapy (IBT) for obesity intervention…
- Trial name
- NCT03855566
- Testing
- Intensive behavioral therapy for obesity
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Southern Mississippi
Sleep, Metabolic Syndrome
Extending Sleep to Reverse Metabolic Syndrome in Middle-aged Adults: Acceptability and Feasibility of a Sleep Intervention
This pilot study will test acceptability and feasibility of a sleep extension intervention in community dwelling, short sleeping, racially/ethnically diverse middle aged adults with Metabolic Syndrome (METs).
- Trial name
- NCT03599388
- Testing
- Self- management for adequate sleep intervention (SASI)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Hormone Deficiency
Outcomes of Adipose Derived Mesenchymal Stem Cells on Sexual Hormone Deficiency
The purpose of this study is to evaluate the safety and effectiveness of adipose derived mesenchymal stem cells (AD-MSCs) therapy on sexual hormone deficiency in the middle-aged patients
- Trial name
- MSCSHD (NCT03346967)
- Testing
- adipose-derived mesenchymal stem cells
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Anesthesia; Adverse Effect
Neurotoxicity of Anesthesia in Middle Aged Patients
for the last 20 years, the increasing reports from non-human studies have raised suspicion that general anesthetics may cause neurotoxic changes in the developing brain that lead to adverse neurodevelopmental outcomes later in…
- Trial name
- NCT04275531
- Testing
- Anesthesia Agent
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Tanta University
Healthy
A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects
A clinical study to assess next-day driving performance following evening administrations of ACT-541468 in middle-aged and elderly subjects
- Trial name
- NCT03892902
- Testing
- ACT-541468, Zopiclone 7.5 mg
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Ovarian Cancer
The Effectiveness of an Online Support Group in Enhancing Recovery Identity and Health-Related Quality of Life
Background Ovarian cancer poses challenges for middle-aged and older patients, impacting physical and self-conceptual aspects. A research gap exists on the impact of online support groups (SPs) on identity synthesis and…
- Trial name
- NCT06145295
- Testing
- mobile online support group (experiment group), offline support group (control group)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Abdominal Obesity, Abdominal Obesity-Metabolic Syndrome
Metabolic Effectiveness of Extracorporeal Shockwave on Abdominal Adiposity
Egyptian Ministry of Health and Population's Preventive Sector, have named obesity as one of the top contributors to the national mortality and morbidity.
- Conditions
- Abdominal Obesity, Abdominal Obesity-Metabolic Syndrome, Abdominal Obesity in Young and Middle Aged Adults
- Trial name
- NCT07686601
- Testing
- conventional balanced, low-calorie diet 1500 k/cal for 12 weeks, aerobic training program, extracorporeal shockwave therapy
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Metabolic Syndrome, Diabetes
Post-prandial Glycaemic Controlling Effects of BSG in Singapore Adults With Metabolic Syndrome
The purpose of this study is to assess the glycaemic controlling effects of BSG and bio-transformed BSG-containing biscuits in Singapore adults with MetS.
- Conditions
- Metabolic Syndrome, Diabetes, Diet Modification
- Trial name
- NCT05421780
- Testing
- autoclaved BSG-containing biscuits, bio-transformed BSG-containing biscuits, control biscuits
- Where
- Singapore
- Volunteers
- 16 people
- Sponsor
- National University of Singapore
Cardiovascular Diseases, Aging
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults.
- Trial name
- NCT03535844
- Testing
- Wolfberry, Healthy diet
- Where
- 2 sites in Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Apnea, Obstructive Sleep Apnea (OSA)
Predictors of the Metabolic Effect of Sleep Loss
To test whether baseline levels of slow wave activity (SWA) during sleep are lower in obese adults, and even lower in persons with sleep disordered breathing (SDB) compared to lean adults.
- Conditions
- Apnea, Obstructive Sleep Apnea (OSA), Obesity
- Trial name
- SDBO (NCT00965783)
- Testing
- Restriction, Extension
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Hot Flashes, Menopause
MsFLASH-04: Pilot Trial: Telephone Behavioral Therapy for Menopause-related Sleep Disturbance
Self-reported sleep complaints are common in peri- and postmenopausal women and have been identified as a key symptom of the menopausal transition.
- Conditions
- Hot Flashes, Menopause, Vasomotor Disturbance, Sleep
- Trial name
- MsFLASH-04 (NCT01936441)
- Testing
- Cognitive Behavioral Therapy-Insomnia (CBT-I), Menopause Education Control (MEC)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Sleep Disorder, Aging
Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers
The goal of this clinical trial is to evaluate the effects of Urolithin A (UA) and Fisetin on improving sleep and aging biomarkers in middle-aged and older adults.
- Trial name
- NCT06990256
- Testing
- Fisetin intervention, Urolithin A intervention
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Huazhong University of Science and Technology
Menopause, Cardiac Function Impaired
Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
- Conditions
- Menopause, Cardiac Function Impaired, Cardiovascular Diseases, Blood Platelet Disorders
- Trial name
- NCT02135575
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Physical Inactivity
MAP to Health Pilot Study: A Physical Activity Intervention for Midlife Adults
The study has two aims: (1) to develop and examine the acceptability of the technological and theoretical frameworks of MAP to Health and (2) to determine whether MAP to Health is related to changes in theoretically identified…
- Trial name
- MAP (NCT05332145)
- Testing
- MAP to Health
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- HealthPartners Institute
Aesthetics, Intradermal Injections
Clinical Evaluation of the Safety and Performance of a Filler in Correction of Mid-face Age-related Volume Deficit
Prospective, single center study, on healthy subjects to evaluate the aesthetic improvement of facial volume, effect on the restoration and/or augmentation in subjects with mid-face age-related volume deficit after injection of a…
- Trial name
- NCT04505319
- Testing
- DEFINISSE CORE FILLER
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Relife S.r.l.
Dry Eye Disease
Evaluation of the Effectiveness of a Community Health Management Program for Dry Eye Disease in Middle-Aged and Elderly Individuals
This study evaluates the effectiveness of a community health management program for middle-aged and elderly patients with dry eye disease (DED).
- Trial name
- NCT06443554
- Testing
- Health Management Intervention Program, Standard Treatment
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Fujian University of Traditional Chinese Medicine
Risk Behavior, Cognitive Decline
Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention
The overarching aim is to develop and deploy a multidomain intervention delivered on a mobile application to help older adults reduce their risk for dementia by improving a set of modifiable lifestyle risk factors associated with…
- Trial name
- NCT04616794
- Testing
- Cognitive Engagement Group, Physical Activity Group, Diet Group
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- LuciLab