Clinical trials: Middle Aged
Acute Otitis Media
Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media
Children ages 2 months to less than 19 years old, who have been diagnosed with a middle ear infection may receive either medicated ear drops (AR01) or glycerin (placebo) ear drops.
- Trial name
- AR01006 (NCT02044341)
- Testing
- AR01, Glycerin ear drops
- Where
- 29 sites in United States
- Volunteers
- 304 people
- Sponsor
- Arbor Pharmaceuticals, Inc.
Diabetes Mellitus, Type 2, Cognitive Impairment
Diabetes and Cognitive Functions in Middle Age
This study will examine the effects of type II diabetes on cognitive functions and mood in middle-aged patients. In addition, the association between cognitive functions and glycemic controls is studied in patients.
- Conditions
- Diabetes Mellitus, Type 2, Cognitive Impairment, Hyperglycemia, Hypoglycemia
- Trial name
- DBC (NCT05919927)
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Immune Response, Inflammation
Effect of Almonds on Immune Strength and Response to Flu Vaccination in Overweight Older Men and Postmenopausal Women: A Randomized Controlled Study
This research study will test the effects of almonds on immune functions and immune response to influenza vaccine in overweight middle-aged men and postmenopausal women
- Trial name
- Almond Immune (NCT05031663)
- Testing
- Almond group, Control Group
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Obesity, Women (Between 30 to 60 Years Old)
Increased Dietary Protein Intake During GLP-1 Medication Use (in Middle-aged Women With Overweight/Obesity)
Middle-aged women with (overweight/)obesity who will begin or have begun GLP-1 medication use will be recruited to complete a 12-week diet intervention study.
- Trial name
- NCT07480109
- Testing
- Protein Rich Foods
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
AAT-APP+: A Novel Brain-training App to Reduce Drinking
This study will explore the feasibility, acceptability, and preliminary effectiveness of a smart phone delivered form of cognitive training intervention (Approach Bias Modification (ABM)) in a non-clinical community sample of…
- Trial name
- NCT04923256
- Testing
- AAT-APP: A novel smart-phone approach-avoidance bias modification intervention
- Where
- Australia
- Volunteers
- 188 people
- Sponsor
- Turning Point
Protein Deficiency, Training Group, Sensitivity
Effects of a Recovery Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing
The investigation will be conducted as a double blinded, randomized, parallel between treatment conditions comparison design with two different groups ingesting a different supplement each one.
- Conditions
- Protein Deficiency, Training Group, Sensitivity, Fatigue, Muscular Atrophy
- Trial name
- NCT05769101
- Testing
- Ingestion of a Post-Workout Supplement, Ingestion of a Maltodextrin Supplement
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joel Puente
Aging
The Effect of Bikram Yoga on Arterial Stiffness and Endothelial Function in Middle-Aged Adults
Arterial stiffening and endothelial dysfunction are correlates of advancing age contributing to the decline in cardioprotection with age.
- Trial name
- NCT02488148
- Testing
- Hot yoga, Non-heated yoga
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Postmenopausal; Menorrhagia, Physical Inactivity
Effects of Dietary Nitrate Intake on Physical Performance of Middle-aged Women
Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 15 physically inactive hypertensive women will participate a 8-day trial, each with two intervention protocols: 1) placebo and 2) beetroot; in…
- Conditions
- Postmenopausal; Menorrhagia, Physical Inactivity, Motor Activity
- Trial name
- NCT05820321
- Testing
- Beetroot juice rich in nitrate, Beetroot juice NO3 depleted
- Where
- 2 sites in Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Overweight or Obesity
HIIT on Overweight Middle-aged Adults
36 middle-aged with overweight adults were divided into three groups: 1. L-HIIT group: the long-interval HIIT group (4 × 4 min Exercise/4 min Rest), 2.
- Trial name
- HIIT (NCT06383442)
- Testing
- L-HIIT, M-HIIT
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Aging
To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults
It will be a two-part study. Part I will be six arms; randomized, double blind, parallel design, placebo-controlled dose ranging study. Part II will be open-label single dose study at the highest dose.
- Trial name
- NCT04823260
- Testing
- Nicotinamide Mononucleotide
- Where
- 2 sites in India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Abinopharm, Inc
Stroke, Stroke (6 Months or More After Onset)
Co-Designed Digital Education and Peer Support for Young and Middle-Aged Stroke Survivors
Stroke survivors often experience persistent unmet needs during long-term recovery. Young and middle-aged stroke survivors may face additional challenges in balancing rehabilitation with work and family responsibilities.
- Trial name
- NCT07725666
- Testing
- Patient-Centered Digital Education and Peer Support Program, Usual Post-Stroke Care
- Volunteers
- 148 people
- Sponsor
- Chang Gung Memorial Hospital
Sleep Disorder, Aging
Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers
The goal of this clinical trial is to evaluate the effects of Urolithin A (UA) and Fisetin on improving sleep and aging biomarkers in middle-aged and older adults.
- Trial name
- NCT06990256
- Testing
- Fisetin intervention, Urolithin A intervention
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Huazhong University of Science and Technology
Pre-biabetes
Effects of Milk Probiotics Intervention on Blood Glucose Control Middle-aged and Elderly People With Pre-diabetes
This study aims to conduct a 8-week probiotics intervention involving for middle-aged and elderly individuals with pre-diabetes, assessing its impact on blood glucose control in comparison to placebo
- Trial name
- NCT06972524
- Testing
- a special probiotics from Mengniu Group, supplemented with milk powder, regular milk powder does not contain any additional supplementation, and the color, flavor, shape, taste, and weight are same with the probiotic milk powder
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Huilian Zhu
Exercise
Differences in Rate of Recovery Between Young and Middle-aged Men After Downhill Running
The aim of this study is to evaluate differences in rate of recovery between young and middle-aged men after prolonged (downhill) running.
- Trial name
- NCT04025723
- Testing
- Downhill running
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gepner Yftach
Physical Activity
Investigations of the Effects and Associated Neural Mechanisms of Different Exercise in People With Metabolic Syndrome
Metabolic syndrome (MetS) is a risk for many chronic diseases of middle-aged and older adults. Hence, prevention and treatment of MetS is a crucial global health issue.
- Trial name
- NCT05672940
- Testing
- Aerobic plus resistance training, Stretching plus breathing training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cardiometabolic Disease, Health Coaching
A Feasibility Study of a Health Coaching Programme for Middle-aged Adults With Cardiometabolic Risk
Cardiometabolic disease has been an increasing trend globally and remains the major cause of morbidity and mortality. Health coaching, a process of goal-oriented and client-centered partnership that is health-focus and through…
- Conditions
- Cardiometabolic Disease, Health Coaching, Middle-aged Adults, Primary Prevention
- Trial name
- NCT05444140
- Testing
- Health coaching
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diet, Food
Acute Resistance Exercise and Hydrolyzed Collagen Supplementation
This study aimed to investigate the effect of different doses of hydrolyzed collagen (HC) with resistance exercise (RE) on whole body collagen synthesis in middle-aged males and females.
- Conditions
- Diet, Food, Nutrition
- Trial name
- NCT06236659
- Testing
- Consumption of three different doses of hydrolyzed collagen (HC) with resistance exercise, Consumption of two different doses of hydrolyzed collagen (HC) with reistance exercise
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rob Erskine