Clinical trials: Middle Aged
Anesthesia; Adverse Effect
Neurotoxicity of Anesthesia in Middle Aged Patients
for the last 20 years, the increasing reports from non-human studies have raised suspicion that general anesthetics may cause neurotoxic changes in the developing brain that lead to adverse neurodevelopmental outcomes later in…
- Trial name
- NCT04275531
- Testing
- Anesthesia Agent
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Tanta University
Healthy
A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects
A clinical study to assess next-day driving performance following evening administrations of ACT-541468 in middle-aged and elderly subjects
- Trial name
- NCT03892902
- Testing
- ACT-541468, Zopiclone 7.5 mg
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Ovarian Cancer
The Effectiveness of an Online Support Group in Enhancing Recovery Identity and Health-Related Quality of Life
Background Ovarian cancer poses challenges for middle-aged and older patients, impacting physical and self-conceptual aspects. A research gap exists on the impact of online support groups (SPs) on identity synthesis and…
- Trial name
- NCT06145295
- Testing
- mobile online support group (experiment group), offline support group (control group)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Abdominal Obesity, Abdominal Obesity-Metabolic Syndrome
Metabolic Effectiveness of Extracorporeal Shockwave on Abdominal Adiposity
Egyptian Ministry of Health and Population's Preventive Sector, have named obesity as one of the top contributors to the national mortality and morbidity.
- Conditions
- Abdominal Obesity, Abdominal Obesity-Metabolic Syndrome, Abdominal Obesity in Young and Middle Aged Adults
- Trial name
- NCT07686601
- Testing
- conventional balanced, low-calorie diet 1500 k/cal for 12 weeks, aerobic training program, extracorporeal shockwave therapy
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Metabolic Syndrome, Diabetes
Post-prandial Glycaemic Controlling Effects of BSG in Singapore Adults With Metabolic Syndrome
The purpose of this study is to assess the glycaemic controlling effects of BSG and bio-transformed BSG-containing biscuits in Singapore adults with MetS.
- Conditions
- Metabolic Syndrome, Diabetes, Diet Modification
- Trial name
- NCT05421780
- Testing
- autoclaved BSG-containing biscuits, bio-transformed BSG-containing biscuits, control biscuits
- Where
- Singapore
- Volunteers
- 16 people
- Sponsor
- National University of Singapore
Early Onset Alzheimer Disease, Alzheimer Disease
Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
Obstructive sleep apnea (OSA) is much more common in the elderly than in the young; the latest studies show prevalence between 45% and 62% in individuals over 60.
- Conditions
- Early Onset Alzheimer Disease, Alzheimer Disease, Obstructive Sleep Apnea Syndromes
- Trial name
- AZAP (NCT01400542)
- Testing
- CPAP Treatment, No treatment
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cardiovascular Diseases, Aging
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults.
- Trial name
- NCT03535844
- Testing
- Wolfberry, Healthy diet
- Where
- 2 sites in Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Apnea, Obstructive Sleep Apnea (OSA)
Predictors of the Metabolic Effect of Sleep Loss
To test whether baseline levels of slow wave activity (SWA) during sleep are lower in obese adults, and even lower in persons with sleep disordered breathing (SDB) compared to lean adults.
- Conditions
- Apnea, Obstructive Sleep Apnea (OSA), Obesity
- Trial name
- SDBO (NCT00965783)
- Testing
- Restriction, Extension
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Sleep Disorder, Aging
Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers
The goal of this clinical trial is to evaluate the effects of Urolithin A (UA) and Fisetin on improving sleep and aging biomarkers in middle-aged and older adults.
- Trial name
- NCT06990256
- Testing
- Fisetin intervention, Urolithin A intervention
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Huazhong University of Science and Technology
Menopause, Cardiac Function Impaired
Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
- Conditions
- Menopause, Cardiac Function Impaired, Cardiovascular Diseases, Blood Platelet Disorders
- Trial name
- NCT02135575
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Aesthetics, Intradermal Injections
Clinical Evaluation of the Safety and Performance of a Filler in Correction of Mid-face Age-related Volume Deficit
Prospective, single center study, on healthy subjects to evaluate the aesthetic improvement of facial volume, effect on the restoration and/or augmentation in subjects with mid-face age-related volume deficit after injection of a…
- Trial name
- NCT04505319
- Testing
- DEFINISSE CORE FILLER
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Relife S.r.l.
Dry Eye Disease
Evaluation of the Effectiveness of a Community Health Management Program for Dry Eye Disease in Middle-Aged and Elderly Individuals
This study evaluates the effectiveness of a community health management program for middle-aged and elderly patients with dry eye disease (DED).
- Trial name
- NCT06443554
- Testing
- Health Management Intervention Program, Standard Treatment
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Fujian University of Traditional Chinese Medicine
Risk Behavior, Cognitive Decline
Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention
The overarching aim is to develop and deploy a multidomain intervention delivered on a mobile application to help older adults reduce their risk for dementia by improving a set of modifiable lifestyle risk factors associated with…
- Trial name
- NCT04616794
- Testing
- Cognitive Engagement Group, Physical Activity Group, Diet Group
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- LuciLab
Psychological Stress
Meditation Apps for Stress Management in Black Women
This randomized remote pilot study will evaluate the feasibility, acceptability, and preliminary effects of two meditation and mindfulness applications among approximately 40 Black women ages 35-64 experiencing moderate to high…
- Trial name
- NCT07807501
- Testing
- Exhale™ Meditation App, Levelhead Mindfulness App
- Volunteers
- 40 people
- Sponsor
- Arizona State University
Cognitive Change
CMI-168 on Cognitive Function in Healthy Middle-aged Men and Women
The investigators propose to conduct the present study in order to primarily assess the effects of CMI-168 in neurocognition enhancement.
- Trial name
- NCT03612752
- Testing
- CMI-168
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cerebos Pacific Limited
Adhesive Capsulitis
Effects of Nunchaku Exercise for Improving Frozen Shoulder
The goal of this clinical trial is to investigate if nunchaku exercise works to treat adhesive capsulitis, or frozen shoulder in middle-aged or older adults. It will also learn about the adherence of this exercise intervention.
- Trial name
- NCT07486193
- Testing
- Shoulder Mobilization and Stretching Exercise (SMSE), Nunchaku Exercise
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Alzheimer's Disease (AD)
Cognitive-motor Intervention Using Virtual Reality for Middle-aged Individuals at High Dementia Risk
The primary objective of this program is to apply a virtual reality (VR) cognitive-motor intervention (compared to active and passive control groups) to delay or slow cognitive decline of middle-aged adults who have a family…
- Trial name
- NCT02832921
- Testing
- cognitive training by virtual reality, watching a scientific TV documentary, treadmill
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Age-related Volume Deficit in the Mid-face
A Study of the Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Cheek Augmentation Using Cannula
The objective of this study is to evaluate the safety and effectiveness of JUVÉDERM VOLUMA® XC injectable gel using cannula in participants seeking correction of age-related volume deficit in the mid-face.
- Trial name
- NCT03438266
- Testing
- JUVÉDERM VOLUMA® XC injectable gel with cannula, JUVÉDERM VOLUMA® XC injectable gel with needle
- Where
- 7 sites in United States
- Volunteers
- 66 people
- Sponsor
- Allergan
Knee Osteoarthritis
Self-administered Acupressure for Knee Osteoarthritis: A Pilot Randomized Controlled Trial
Objectives: To test the feasibility of the study design and clinical effects of self-administered acupressure on relieving knee osteoarthritis (OA) pain.
- Trial name
- NCT03155737
- Testing
- Self-acupressure, Knee health education
- Where
- Hong Kong
- Volunteers
- 35 people
- Sponsor
- The Hong Kong Polytechnic University
Breast Cancer Survivors
Rowing Following Breast Cancer Chemotherapy
There are more than 3.8 million breast cancer survivors in the United States and cancer survivors have a higher risk of cardiovascular disease (CVD) due to chemotherapy than adults without cancer.
- Trial name
- NCT05848141
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Florida