Clinical trials: Migraine Disease
Migraine
A Study Of The Safety, Tolerability, And Pharmacokinetics Of Multiple Doses Of PF-05180999 In Healthy Adults
PF-05180999 is a novel phosphodiesterase-2 (PDE2) inhibitor. The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of multiple doses of PF-05180999 administered twice daily over 14 days.
- Trial name
- NCT01981486
- Testing
- PF-05180999 Tablets
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Migraine Disorders
Defining the Sympathetic Skin Response of Migraineurs in the Facial Area
The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation…
- Trial name
- NCT03772860
- Testing
- Pain stimulation, Visual stimulation, Auditory stimulation
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Migraine, Tension Headache
The Prevalence of Osmophobia in Migraine and Tension-Type Headache Patients and Its Association With Migraine Symptoms Over a Period of 6 Months
The goal of this observational study is to learn about the frequency and diagnostic value of osmophobia, which is a sensitivity to smell, in people with migraine compared to those with tension-type headache.
- Trial name
- NCT07329127
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
Migraine
(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist
To compare Botox-treated and Botox-untreated symptomatic tissues (defined as areas where the head hurts and the pain is felt) of chronic migraine (CM) patients using molecular studies.
- Trial name
- NCT03381261
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Migraine, Migraine With Aura
A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess STS101 in the Acute Treatment of Migraine
Study STS101-007 is a randomized, double-blind, parallel group, placebo-controlled, multicenter study to evaluate the efficacy, safety, and tolerability of single doses of STS101 (dihydroergotamine nasal powder) in the acute…
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- SUMMIT (NCT04940390)
- Testing
- Dihydroergotamine
- Where
- 127 sites in United States
- Volunteers
- 1,591 people
- Sponsor
- Satsuma Pharmaceuticals, Inc.
Ischemic Stroke, Migraine
Sensitivity to Acute Cerebral Ischemia in Migrainers
Sensitivity to Acute Middle cerebral or intracranial Carotid artery Occlusion in MIGrainers (SMCO-MIG) is a prospective multi-center study to determine if migraine induces a faster infarct growth as assessed by initial multimodal…
- Conditions
- Ischemic Stroke, Migraine, Migraine With Aura
- Trial name
- SAMCO-MIG (NCT03301441)
- Testing
- questionnaire ef-ID Migraine
- Where
- France
- Volunteers
- 605 people
- Sponsor
- University Hospital, Montpellier
Bruxism
TMJ-1001 Bruxism Run-In/Pivotal Trial
The study is an open-label, prospective, multi-center, randomized, two treatment parallel, comparison study of the TMJ NextGeneration(TM) and custom-fit occlusal splint in the reduction of nocturnal bruxism episodes and monthly…
- Trial name
- NCT02269553
- Testing
- TMJ(TM) NextGeneration, Standard Hard TMJD Splint
- Sponsor
- TMJ Health
Ménière
Treatment of Meniere's Disease With Migraine Medications
Meniere's disease (MD) is a chronic disease with a variety of fluctuating signs and symptoms, which include vertigo, hearing loss, tinnitus (ringing noise in the ear), aural pressure (feeling of ear fullness), and disequilibrium…
- Trial name
- NCT05582837
- Testing
- nortriptyline + topiramate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Irvine
Migraine, Migraine Prophylaxis
The Real-world Study of Rimegepant Treatment in Female Migraine Patients of China
The goal of this observational study is to learn about the effects and safety of Rimegepant in women, especially young and middle-aged women, who take Rimegepant to treat their migraine in the real world.
- Trial name
- NCT06728345
- Testing
- Rimegepant
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Migraine
Tandem OnabotulinumtoxinA Galcanezumab Emerging Therapeutic Headache Elimination Research Study
This is a multicenter, double-blind, placebo-controlled study assessing the effectiveness of Galcanezumab as an add-on therapy for Migraine participants on a stable migraine prophylaxis regimen including Botox with or without one…
- Trial name
- TOGETHER (NCT05492695)
- Testing
- Galcanezumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Diamond Headache Clinic
Migraine Disorders, Medication-overuse Headache
Longitudinal Study of the Patients With Medication-overuse Headache or Migraine That Completed Baseline MRI
This is a phone interview research study for patients with migraine or medication-overuse headache (MOH) who have completed baseline MRI scans.
- Trial name
- LMMM (NCT05528081)
- Testing
- Phone interview
- Where
- China
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Wei Dai
Migraine Disorders
Transcranial Direct Current Simulation in Chronic Migraine
This study is a pilot, double-blind, placebo-controlled, randomized trial aiming to compare the effects of transcranial direct current stimulation in Chronic Migraine.
- Trial name
- NCT02817139
- Testing
- TDCS
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of Paraíba
Migraine Headache
Intravenous Fluid Therapy for the Treatment of Emergency Department Patients With Migraine Headache
The purpose of this study is to determine whether patients in the emergency department with migraine headache who are administered an intravenous fluid bolus will report greater improvement in pain scores than control patients.
- Trial name
- NCT02933060
- Testing
- Normal saline (1000 mL), Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cooper Health System
Foramen Ovale, Patent
The Paradigm II Trial: PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemic Attack, Migraine or Decompression Illness
The primary objective of this study is to demonstrate the safety and efficacy of the PFX Closure System when utilized for patent foramen ovale (PFO) in patients suffering from cryptogenic stroke (undetermined cause of stroke)…
- Trial name
- NCT00196040
- Testing
- PFX Closure System
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Cierra
Headache Disorders, Primary
Pediatric Headche Assessment Using HIT 6
The study is a prospective cohort study. The study population will include 100 children aged 6-18 years suffering from headaches who visited the Pediatric Neurology Clinic at Bnai Zion Medical Center and completed both the…
- Trial name
- NCT06598813
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
Migraine, Headache
A Study of the Safety and Efficacy of MK-6096 for Migraine Prophylaxis in Participants With Episodic Migraine (MK-6096-020)
The purpose of this study is to evaluate the safety and efficacy of MK-6096 versus placebo for preventing migraines in participants with episodic migraine.
- Trial name
- NCT01513291
- Testing
- MK-6096
- Volunteers
- 237 people
- Sponsor
- Merck Sharp & Dohme LLC
Migraine With Aura, Migraine
The Effect of Connective Tissue Massage in Patients With Migraine
The aim of this study was to investigate the effectiveness of connective tissue massage in patients with migraine
- Conditions
- Migraine With Aura, Migraine, Migraine Without Aura, Connective Tissue Diseases
- Trial name
- NCT04171362
- Testing
- Connective Tissue Massage, Education
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Ankara Yildirim Beyazıt University
Headache
Prospective ED Headache Cohort Study
The purpose of this study is to determine how often headaches recur and to learn how to predict continued suffering from headache after emergency department discharge.
- Trial name
- NCT00313703
- Where
- United States
- Volunteers
- 477 people
- Sponsor
- Montefiore Medical Center
Migraine
Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?
Mechanism-based choice of therapy for pain: Can successful prevention of migraine be coupled to a psychophysical pain modulation profile?
- Trial name
- NCT01161017
- Testing
- Amitriptyline, Topiramate
- Where
- Israel
- Volunteers
- 67 people
- Sponsor
- Rambam Health Care Campus
Migraine, With or Without Aura
Safety and Efficacy Study in Adult Subjects With Acute Migraines
The purpose of this study is to compare the efficacy of BHV-3000 (rimegepant) versus placebo in subjects with Acute Migraines
- Trial name
- NCT03235479
- Testing
- Rimegepant
- Where
- 50 sites in United States
- Volunteers
- 1,485 people
- Sponsor
- Pfizer