Clinical trials: Migraine Disorder
Migraine
Abortive Effect of an Ear Insufflator on Migraine
Evaluate the effectiveness of air insufflation in aborting (stopping) an acute episode of migraine and compare it with a placebo effect of using the same procedure but without active insufflation.
- Trial name
- NCT02614378
- Testing
- air insufflation
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Carrick Institute for Graduate Studies
Migraine, Episodic Migraine
Energy for the Brain
Approx. one billion people are suffering from migraine worldwide and yet, therapeutic options are still very limited. Research suggests that changes in energy metabolism could be part of migraine pathophysiology.
- Trial name
- MigraKet (NCT03132233)
- Testing
- Beta-hydroxybutyrate calcium and magnesium salt
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Basel, Switzerland
Migraine
Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression
Migraine is a common and possible hereditary disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human…
- Trial name
- NCT04912752
- Testing
- Migraine CNV
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Chronic Migraine Headache, Radiofrequency Ablation
The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine
The study included 100 patients diagnosed with chronic migraine (CM) who received a diagnosis from the headache clinics of the Neurology Department of Adnan Menderes University Hospitals between May 2025 and May 2026.
- Conditions
- Chronic Migraine Headache, Radiofrequency Ablation, Greater Occipital Nerve Block, Calcitonin Gene-related Peptide
- Trial name
- NCT07395908
- Testing
- Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Migraine, Migraine With or Without Aura
Evaluation of a Wearable Device for Acute Treatment of Migraines
The goal of this clinical trial is to determine the efficacy of a new, improved neuromodulation device that can be worn on the head and neck to relieve migraine pain.
- Conditions
- Migraine, Migraine With or Without Aura, Migraine, Acute, Migraine Headache
- Trial name
- NCT07015125
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Hinge Health, Inc
Migraine, Facial Pain or Pressure
Visual Instillation of Sphenopalatine-block Intervention for ONgoing Migraine
The goal of this double-blinded, randomized placebo controlled clinical trial is to to see if using a numbing medicine (lidocaine) on certain areas inside the nose can help with headaches, neck pain, facial pain and pressure, and…
- Conditions
- Migraine, Facial Pain or Pressure, Headache
- Trial name
- VISION (NCT07764783)
- Testing
- Topical solution of 4% lidocaine, Saline 0.9%
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Association of Migraine Disorders
Migraine Disorders
A Multicenter Assessment of ALD403 in Chronic Migraine
The purpose of this study is to assess ALD403 in the prevention of migraine headache in chronic migraineurs.
- Trial name
- NCT02275117
- Testing
- ALD403
- Where
- 92 sites in United States, Australia and 2 more
- Volunteers
- 665 people
- Sponsor
- Alder Biopharmaceuticals, Inc.
Vestibular Migraine
The R-E-V-I-V-A-L Study
Vestibular migraine (VM) is one of the most common vestibular disorders, affecting 1.0% to 2.7% of the general population1, 7% of patients with definite migranous vertigo in dizziness clinics2, as well as 10.3% of VM patients in…
- Trial name
- NCT06992674
- Testing
- Rimegepant
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary Headache Disorder
Gender Differences and Features of the Clinical Course of Primary Headaches
The pathophysiological mechanisms that underlie primary headache disorders, such as migraine and cluster headache (CH), are complex and not yet fully clarified.
- Trial name
- NCT05760625
- Testing
- analysis BDNF
- Where
- Uzbekistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tashkent Medical Academy
Migraine Headache
Greater Occipital Nerve Block for Migraine Prophylaxis
Migraine is a common neurological condition that can be disabling, particularly if chronic. Greater occipital nerve (GON) block has been utilized for decades for the treatment of migraine in the absence of a single randomized…
- Trial name
- NCT00915473
- Testing
- bupivicaine, normal saline, methylprednisolone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Menstrual Migraine
Fremanezumab for the Prevention of Menstrually-related Migraine Attacks
The goal of this observational study is to compare, in real-world clinical practice, the effect of fremanezumab on menstrual migraine to the effect of fremanezumab on non-perimenstrual attacks.
- Trial name
- FROMM (NCT06659120)
- Testing
- Fremanezumab
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Headache, Headache Disorders
Responding With Evidence and Access for Childhood Headaches
This comparative effectiveness study will clarify current first-line preventive treatment approaches for use by neurologists, psychologists, and primary care providers in the context of real world care, and will demonstrate the…
- Conditions
- Headache, Headache Disorders, Headache, Migraine, Migraine
- Trial name
- NCT05889624
- Testing
- CBT, Amitriptyline
- Where
- 15 sites in United States
- Volunteers
- 400 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Migraine
Efficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing Regimens
The purpose of this study is to compare the efficacy and safety of daily and every other day dosing of rimegepant to placebo as a preventive treatment for episodic migraine.
- Trial name
- NCT05217927
- Testing
- Rimegepant 75mg daily dosing, Rimegepant 75mg every other day dosing
- Where
- 107 sites in United States, Austria and 8 more
- Volunteers
- 1,415 people
- Sponsor
- Pfizer
Migraine
Dexamethasone for Migraine - Dose Comparison
Dexamethasone is an evidence-based treatment of acute migraine. This is a randomized comparison of two different doses of dexamethasone for acute migraine. All patients will also be treated with metoclopramide.
- Trial name
- NCT04112823
- Testing
- Dexamethasone 4mg, Dexamethasone 16mg
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Montefiore Medical Center
Migraine
The Safety and Efficacy of Divalproex Sodium Extended-Release Tablets in Migraine Prophylaxis: A Study in Adolescents
The purpose of this study is to determine whether Depakote ER is safe and effective in the reduction of occurrence of migraine headaches in adolescents.
- Trial name
- NCT00195741
- Testing
- divalproex sodium
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Abbott
Episodic Migraine, Chronic Migraine
i-NEED: NEw migrainE Drugs Database
Approved by the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) starting in 2018, anti-CGRP monoclonal antibodies (anti-CGRP mAbs) represent the first true revolution in the preventive treatment of…
- Conditions
- Episodic Migraine, Chronic Migraine, Medication Overuse Headache
- Trial name
- i-NEED (NCT07103694)
- Testing
- anti-CGRP monoclonal antibodies, gepants, combination of sumatriptan and naproxen
- Where
- 2 sites in Italy
- Volunteers
- 2,641 people
- Sponsor
- IRCCS San Raffaele Roma
Migraine
Trial of Comprehensive Migraine Intervention
Despite the fact that more than 10% of Americans suffer from migraine, this headache disorder is often not diagnosed and not appropriately treated.
- Trial name
- NCT01071317
- Testing
- Naproxen, Sumatriptan, Migraine education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Migraine Disorders
Comparison of Great Occipital Nerve and Supraorbital Nerve Blockade Methods at Treatment of Acute Migraine Attack in the Emergency Department
Aim Acute migraine attack is a clinical condition that is frequently encountered in emergency departments and varies from patient to patient in terms of treatment modalities.
- Trial name
- NCT04491474
- Testing
- Lidocaine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Migraine, Headache
Registry for Migraine - Structural and Functional MRI Before and After Erenumab Treatment
This study aims to investigate structural and functional cerebral changes using magnetic resonance imaging before and after treatment with erenumab in patients with migraine.
- Trial name
- REFORM (NCT04674020)
- Testing
- Erenumab
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Danish Headache Center
Migraine Disorders
BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Participants With Chronic Migraine
This study will evaluate the efficacy and safety of BOTOX® (Botulinum Toxin Type A) compared with placebo as headache prophylaxis in Chinese participants with chronic migraine.
- Trial name
- NCT03193346
- Testing
- botulinum toxin Type A
- Sponsor
- Allergan